Table of contents
Volume 418 Number 6893 pp1-110
Opinion
A Human Stem Cell Project? p1
Advances in the study of embryonic and adult stem cells offer opportunities to boost research on both cell types towards clinical applications. But funding and coordination at national levels will be required to make the most effective progress.
doi:10.1038/418001a
News
Fire-fighting senators move to set up wildfire research institutes p3
Tony Reichhardt
doi:10.1038/418003a
Top physics lab names its leader p3
David Cyranoski
doi:10.1038/418003b
News
Visitors to AIDS conference trapped in web of red tape p4
Declan Butler
doi:10.1038/418004a
Gulf War syndrome research poised for cash injection p4
Jonathan Knight
doi:10.1038/418004b
Naturejobs
Special ReportRiding the biotech rollercoaster p4
The biotech scene, although volatile, will continue to provide jobs. But potential employees should prepare for a bumpy ride, say Paul Smaglik and Adam Smith.
Paul Smaglik and Adam Smith
doi:10.1038/nj6893-04a
News
Bell Labs inquiry spreads to superconductors p5
Geoff Brumfiel
doi:10.1038/418005a
Biotech woes set to hit academics p5
Jonathan Knight
doi:10.1038/418005b
Recriminations inflame UK research debate p6
David Adam
doi:10.1038/418006a
Angry scientists march on Moscow in budget protest p6
Bryon MacWilliams
doi:10.1038/418006b
US exchange scheme offers a taste of Europe p7
Quirin Schiermeier
doi:10.1038/418007a
France hails milestone in start-ups p7
Sally Goodman
doi:10.1038/418007b
news feature
Data visualization: Picture this p11
Drowning in data? New visualization techniques could help. Philip Ball discovers, among other things, how to plot a seven-dimensional graph.
Philip Ball
doi:10.1038/418011a
Developmental biology: Your destiny, from day one p14
The mammalian body plan starts being laid down from the moment of conception, it has emerged. Helen Pearson considers the implications of a surprising shift in embryological thinking.
Helen Pearson
doi:10.1038/418014a
Correspondence
Population should be on the Johannesburg agenda p17
High fertility rates continue to threaten both the environment and human well-being.
Wolfgang Lutz and Mahendra Shah
doi:10.1038/418017a
Beautiful vistas, but is this really science? p17
Michael Phillips
doi:10.1038/418017b
Solve postgrad problems to attract new scientists p17
T. L. Raoul Tan and Simone Lohner
doi:10.1038/418017c
Book Reviews
Evolution under pressure p19
A look at the controversy about industrial melanism in the peppered moth.
Jerry A. Coyne reviews Of Moths and Men: Intrigue, Tragedy and the Peppered Moth by Judith Hooper
doi:10.1038/418019a
Kept in captivity p20
doi:10.1038/418020a
Competition between women p20
Elizabeth Cashdan reviews A Mind of Her Own: The Evolutionary Psychology of Women by Anne Campbell
doi:10.1038/418020b
Science in culture p21
David Cyranoski reviews
doi:10.1038/418021a
News and Views
Biomedicine: Stem-cell competition p25
The debate continues over the relative merits of using embryonic and adult stem cells for research — and perhaps, one day, to treat patients. Two new papers look at the abilities of these remarkable cells.
Stuart H. Orkin and Sean J. Morrison
doi:10.1038/418025a
100 and 50 years ago p26
doi:10.1038/418026a
Planetary science: An older face for Mars p27
Mars has a north–south divide in the age of its surface, as judged by the density of impact craters. Altimetry data, which by inference provide a subsurface view of the planet, reveal that the divide is only skin deep.
Sean C. Solomon
doi:10.1038/418027a
Embryology: Fluid flow and broken symmetry p29
The asymmetries between the right- and left-hand sides of the body are initiated at an early stage of development. Two groups provide welcome news of progress in revealing the mechanism concerned and its generality.
Claudio D. Stern
doi:10.1038/418029a
Materials science: Crystallization of silicon ideas p30
The more desirable form of silicon for use in display screens is also the more expensive to manufacture. Understanding how crystalline silicon forms could be a key to cheaper communications devices.
John Robertson
doi:10.1038/418030a
Genome sequencing: Stick it in the family album p30
Chris Gunter
doi:10.1038/418030b
Planet formation: Enigmatic emission p31
The detection of infrared emission from the dusty disk around a distant star signals the presence of the H3+ ion. The finding may provide a vital clue to how hydrogen and helium condense into gas-giant planets.
Takeshi Oka
doi:10.1038/418031a
Metabolism: Demand management in cells p33
Many researchers have tried to increase the flux through metabolic pathways in cells by raising the supply of metabolic enzymes. Little attention has been paid to the demand side of the equation — until now.
Stephen Oliver
doi:10.1038/418033a
Relativity: Special treatment p34
The detection of cosmic rays with unexpectedly high energies has prompted a rethink of Einstein's theory of special relativity. A new formulation, called 'doubly special relativity', might be the answer.
Giovanni Amelino-Camelia
doi:10.1038/418034a
Palaeontology: Early land vertebrates p35
A 350-million-year-old fossil provides evidence of an almost unknown stage in the origin of land vertebrates. It is also a reminder of how little is known of the relationships between the main lineages of amphibians and reptiles.
Robert Carroll
doi:10.1038/418035a
Brief Communications
Left–right development: Conserved function for embryonic nodal cilia p37
A similar mechanism may underlie the handedness seen in all vertebrate body plans.
Jeffrey J. Essner, Kyle J. Vogan, Molly K. Wagner, Clifford J. Tabin, H. Joseph Yost and Martina Brueckner
doi:10.1038/418037a
First paragraph | Full Text | PDF (152K) | Supplementary information
See also: News and Views by Stern
Gene expression: RNA interference in adult mice p38
Anton P. McCaffrey, Leonard Meuse, Thu-Thao T. Pham, Douglas S. Conklin, Gregory J. Hannon and Mark A. Kay
doi:10.1038/418038a
First paragraph | Full Text | PDF (96K) | Supplementary information
Orbital physics (Communication arising): Experimental quest for orbital waves p39
M. Grüninger, R. Rückamp, M. Windt, P. Reutler, C. Zobel, T. Lorenz, A. Freimuth and A. Revcolevschi
doi:10.1038/418039a
First paragraph | Full Text | PDF (77K)
Orbital physics (Communication arising): Experimental quest for orbital waves p40
E. Saitoh, S. Okamoto, K. Tobe, K. Yamamoto, T. Kimura, S. Ishihara, S. Maekawa and Y. Tokura
doi:10.1038/418040a
First paragraph | Full Text | PDF (54K)
Articles
Pluripotency of mesenchymal stem cells derived from adult marrow p41
Yuehua Jiang, Balkrishna N. Jahagirdar, R. Lee Reinhardt, Robert E. Schwartz, C. Dirk Keene, Xilma R. Ortiz-Gonzalez, Morayma Reyes, Todd Lenvik, Troy Lund, Mark Blackstad, Jingbo Du, Sara Aldrich, Aaron Lisberg, Walter C. Low, David A. Largaespada and Catherine M. Verfaillie
doi:10.1038/nature00870
Abstract | Full Text | PDF (838K) | Supplementary information
See also: News and Views by Orkin & Morrison
Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease p50
Jong-Hoon Kim, Jonathan M. Auerbach, José A. Rodríguez-Gómez, Iván Velasco, Denise Gavin, Nadya Lumelsky, Sang-Hun Lee, John Nguyen, Rosario Sánchez-Pernaute, Krys Bankiewicz and Ron McKay
doi:10.1038/nature00900
Abstract | Full Text | PDF (469K)
See also: News and Views by Orkin & Morrison
Letters to Nature
CO and H3+ in the protoplanetary disk around the star HD141569 p57
Sean D. Brittain and Terrence W. Rettig
doi:10.1038/nature00800
First paragraph | Full Text | PDF (185K)
See also: News and Views by Oka
Interpretation of tomography and spectroscopy as dual forms of quantum computation p59
César Miquel, Juan Pablo Paz, Marcos Saraceno, Emanuel Knill, Raymond Laflamme and Camille Negrevergne
doi:10.1038/nature00801
First paragraph | Full Text | PDF (144K)
Mechanism of hydrogen-induced crystallization of amorphous silicon p62
Saravanapriyan Sriraman, Sumit Agarwal, Eray S. Aydil and Dimitrios Maroudas
doi:10.1038/nature00866
First paragraph | Full Text | PDF (254K)
See also: News and Views by Robertson
Muted climate variations in continental Siberia during the mid-Pleistocene epoch p65
Alexander A. Prokopenko, Douglas F. Williams, Mikhail I. Kuzmin, Eugene B. Karabanov, Galina K. Khursevich and John A. Peck
doi:10.1038/nature00886
First paragraph | Full Text | PDF (613K)
Mineralogy of the mid-ocean-ridge basalt source from neodymium isotopic composition of abyssal peridotites p68
Vincent J. M. Salters and Henry J. B. Dick
doi:10.1038/nature00798
First paragraph | Full Text | PDF (197K)
An early tetrapod from 'Romer's Gap' p72
J. A. Clack
doi:10.1038/nature00824
First paragraph | Full Text | PDF (456K) | Supplementary information
See also: News and Views by Carroll
A host–parasite interaction rescues Drosophila oogenesis defects p76
Diana J. Starr and Thomas W. Cline
doi:10.1038/nature00843
First paragraph | Full Text | PDF (168K)
Sequence and analysis of chromosome 2 of Dictyostelium discoideum p79
Gernot Glöckner, Ludwig Eichinger, Karol Szafranski, Justin A. Pachebat, Alan T. Bankier, Paul H. Dear, Rüdiger Lehmann, Cornelia Baumgart, Genís Parra, Josep F. Abril, Roderic Guigó, Kai Kumpf, Budi Tunggal, Edward Cox, Michael A. Quail, Matthias Platzer, André Rosenthal, Angelika A. Noegel, Bart G. Barrell, Marie-Adèle Rajandream, Jeffrey G. Williams, Robert R. Kay, Adam Kuspa, Richard Gibbs, Richard Sucgang, Donna Muzny, Brian Desany, Kathy Zeng, Baoli Zhu, Pieter de Jong, Theodor Dingermann, Günther Gerisch, Peter Philippsen, Michael Schleicher, Stephan C. Schuster and Thomas Winckler
doi:10.1038/nature00847
First paragraph | Full Text | PDF (292K) | Supplementary information
See also: News and Views by Gunter
Intracellular calcium stores regulate activity-dependent neuropeptide release from dendrites p85
Mike Ludwig, Nancy Sabatier, Philip M. Bull, Rainer Landgraf, Govindan Dayanithi and Gareth Leng
doi:10.1038/nature00822
First paragraph | Full Text | PDF (363K)
Capacitance steps and fusion pores of small and large-dense-core vesicles in nerve terminals p89
Vitaly A. Klyachko and Meyer B. Jackson
doi:10.1038/nature00852
First paragraph | Full Text | PDF (601K) | Supplementary information
Dynamic interactions of cyclic AMP transients and spontaneous Ca2+ spikes p93
Yuliya V. Gorbunova and Nicholas C. Spitzer
doi:10.1038/nature00835
First paragraph | Full Text | PDF (749K) | Supplementary information
Determination of left–right patterning of the mouse embryo by artificial nodal flow p96
Shigenori Nonaka, Hidetaka Shiratori, Yukio Saijoh and Hiroshi Hamada
doi:10.1038/nature00849
First paragraph | Full Text | PDF (218K) | Supplementary information
See also: News and Views by Stern
AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification p99
Svend K. Petersen-Mahrt, Reuben S. Harris and Michael S. Neuberger
doi:10.1038/nature00862
First paragraph | Full Text | PDF (843K)
Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast p104
Zu-Wen Sun and C. David Allis
doi:10.1038/nature00883
First paragraph | Full Text | PDF (263K) | Supplementary information
corrigenda: BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes p108
Philippe Bouillet, Jared F. Purton, Dale I. Godfrey, Li-Chen Zhang, Leigh Coultas, Hamsa Puthalakath, Marc Pellegrini, Suzanne Cory, Jerry M. Adams and Andreas Strasser
doi:10.1038/nature00885
corrigenda: Sudden aseismic fault slip on the south flank of Kilauea volcano p108
Peter Cervelli, Paul Segall, Kaj Johnson, Michael Lisowski and Asta Miklius
doi:10.1038/nature00925
New on the Market
High-throughput screening p109
Microarrays, samplers and management systems for HTS.
doi:10.1038/418109a
