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Nature 417, 954-958 (27 June 2002) | doi:10.1038/nature00821;
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VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism
Vascular endothelial growth factor (VEGF) is a principal regulator of blood vessel formation and haematopoiesis, but the mechanisms by which VEGF differentially regulates these processes have been elusive. Here we describe a regulatory loop by which VEGF controls survival of haematopoietic stem cells (HSCs).
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