Table of contents
Volume 417 Number 6892 pp3-980
Naturejobs
ProspectsThe digital revolution p3
Paul Smaglik
doi:10.1038/nj6892-03a
Careers and Recruitment
Silicon dreams in the biology lab p4
For many biologists, the idea of creating a computer model of a living cell is anathema. But for mathematicians and physicists, the pursuit of such a goal is proving irresistible, says Diane Gershon.
Diane Gershon
doi:10.1038/nj6892-04a
Cell biology gets plugged in p6
The choice of potential drug targets thrown up by genomics data is overwhelming, which is why several firms are now offering drug companies a model solution. Diane Gershon reports.
Diane Gershon
doi:10.1038/nj6892-06a
Computerized role models p7
Japan's push to create a virtual cell signals a new approach to research, says Robert Triendl.
Robert Triendl
doi:10.1038/nj6892-07a
Opinion
Anyone for neutrons? p883
There is a strong case for constructing a major new neutron source somewhere in Europe. The obstacles to progress towards this goal reflect much that is problematic about the organization of European science.
doi:10.1038/417883a
News
Code of conduct for bioethics branded 'soft' on corporate ties p885
Nell Boyce
doi:10.1038/417885a
Bush's advisers lean towards ban on research cloning p885
Erika Check
doi:10.1038/417885b
Scientists jailed for alleged theft from Harvard laboratory p886
Rex Dalton
doi:10.1038/417886a
Fight against terror 'needs science institute' p887
Erika Check
doi:10.1038/417887a
Lack of funds puts 'bubble fusion' replication on hold p887
Geoff Brumfiel
doi:10.1038/417887b
CERN puts research on hold to build collider p888
Alison Abbott
doi:10.1038/417888a
Ocean carbon study to quit Hawaii p888
Virginia Gewin
doi:10.1038/417888b
NASA launch heralds fresh wave of comet exploration p889
Tony Reichhardt
doi:10.1038/417889a
Astronaut lands top research post in new French government p889
Sally Goodman
doi:10.1038/417889b
news feature
Quantum physics: Altered states p892
During the 1990s, ultracold gases were used to open up a new and often bizarre frontier of physics. Now researchers are poised to use similar gases to enter another, equally intriguing, realm. Mark Haw reports.
Mark Haw
doi:10.1038/417892a
Proteomics: The society of proteins p894
Having realized that proteins usually do their jobs by combining to form transient complexes, biologists are queuing up to study these structures using a powerful electron-microscopy technique. Alison Abbott reports.
Alison Abbott
doi:10.1038/417894a
Correspondence
Conflicts around a study of Mexican crops p897
Nature published a paper last year claiming that transgenic DNA had become genetically incorporated into traditional maize in Mexico. A debate ensued ...
Andrew V. Suarez
doi:10.1038/417897a
Conflicts around a study of Mexican crops p897
Kenneth Worthy, Richard C. Strohman and Paul R. Billings
doi:10.1038/417897b
Conflicts around a study of Mexican crops p897
Matthew Metz and Johannes Fütterer
doi:10.1038/417897c
Conflicts around a study of Mexican crops p898
Nick Kaplinsky
doi:10.1038/417898a
Impact-factor rewards affect Spanish research p898
Evaristo Jiménez-Contreras, Emilio Delgado López-Cózar, Rafael Ruiz-Pérez and Víctor M. Fernández
doi:10.1038/417898b
Book Reviews
Our molecular history p899
What can DNA evidence tell us about human evolution?
Masatoshi Nei reviews Where Do We Come From? The Molecular Evidence for Human Descent by Jan Klein and Naoyuki Takahata
doi:10.1038/417899a
Winning the fight against liver disease p900
Arie J. Zuckerman reviews Hepatitis B: The Hunt for a Killer Virus by Baruch S. Blumberg
doi:10.1038/417900a
A philosophical liberator p900
Hans-Johann Glock reviews Invariances: The Structure of the Objective World by Robert Nozick
doi:10.1038/417900b
Medical models p901
doi:10.1038/417901a
News and Views
Astronomy: Through a lens brightly p905
Gravitational lensing of light from some of the most distant objects known could be more widespread than had been thought. If so, it could be good — and bad — news for cosmologists.
Edwin L. Turner
doi:10.1038/417905a
Cancer: Lucky draw in the gene raffle p906
The Cancer Genome Project intends to search every human gene for cancer-related mutations. Its first success is the discovery of such mutations in the BRAF gene.
Pamela M. Pollock and Paul S. Meltzer
doi:10.1038/417906a
Materials science: Thin-film cliffhanger p907
Thin films are grown ideally one atomic layer at a time, but atoms can move along and between layers. The model for film growth has now been extended to describe how atoms tumble over 'cliffs' between layers.
Max G. Lagally and Zhenyu Zhang
doi:10.1038/417907a
100 and 50 years ago p909
doi:10.1038/417909a
Plant–microbe interactions: A receptor in symbiotic dialogue p910
Proteins that help plants connect with symbiotic microbes have been identified. These proteins are related to receptors in animals and plants that function in the innate immune system and organ development.
Herman P. Spaink
doi:10.1038/417910a
Earth science: How old roots lose their bounce p911
Active mountain belts have crustal 'roots' that gravitationally balance the high topography. So why do old mountains that have been worn flat by erosion still have these roots?
David James
doi:10.1038/417911a
Genomic imprinting: Piece of cake p913
Knocking out a minor form of the Igf2 messenger RNA from the placenta in mice has surprisingly strong effects on nutrient transport to the fetus. This has implications for the theory of maternal–paternal genetic conflict.
Benjamin Tycko and Argiris Efstratiadis
doi:10.1038/417913a
Daedalus: Darkened light p914
David Jones
doi:10.1038/417914a
Brief Communications
Pest Control: Caffeine as a repellent for slugs and snails p915
At high concentrations this stimulant becomes a lethal neurotoxin to garden pests.
Robert G. Hollingsworth, John W. Armstrong and Earl Campbell
doi:10.1038/417915a
First paragraph | Full Text | PDF (80K)
Development: Early-pregnancy origins of low birth weight p916
Gordon C. S. Smith, Emily J. Stenhouse, Jennifer A. Crossley, David A. Aitken, Alan D. Cameron and J. Michael Connor
doi:10.1038/417916a
First paragraph | Full Text | PDF (40K)
Article
Sub-laser-cycle electron pulses for probing molecular dynamics p917
Hiromichi Niikura, F. Légaré, R. Hasbani, A. D. Bandrauk, Misha Yu. Ivanov, D. M. Villeneuve and P. B. Corkum
doi:10.1038/nature00787
Abstract | Full Text | PDF (189K)
Letters to Nature
Magnification of light from many distant quasars by gravitational lenses p923
J. Stuart B. Wyithe and Abraham Loeb
doi:10.1038/nature00794
First paragraph | Full Text | PDF (139K)
See also: News and Views by Turner
The nature and transport mechanism of hydrated hydroxide ions in aqueous solution p925
Mark E. Tuckerman, Dominik Marx and Michele Parrinello
doi:10.1038/nature00797
First paragraph | Full Text | PDF (321K)
Nonlinear dynamics of ice-wedge networks and resulting sensitivity to severe cooling events p929
L. J. Plug and B. T. Werner
doi:10.1038/nature00796
First paragraph | Full Text | PDF (465K)
Waning buoyancy in the crustal roots of old mountains p933
Karen M. Fischer
doi:10.1038/nature00855
First paragraph | Full Text | PDF (212K)
See also: News and Views by James
Bird-like fossil footprints from the Late Triassic p936
Ricardo N. Melchor, Silvina de Valais and Jorge F. Genise
doi:10.1038/nature00818
First paragraph | Full Text | PDF (225K)
Overlap of internal models in motor cortex for mechanical loads during reaching p938
Paul L. Gribble and Stephen H. Scott
doi:10.1038/nature00834
First paragraph | Full Text | PDF (294K) | Supplementary information
Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth p941
Kevin C. Wang, Vuk Koprivica, Jieun A. Kim, Rajeev Sivasankaran, Yong Guo, Rachel L. Neve and Zhigang He
doi:10.1038/nature00867
First paragraph | Full Text | PDF (211K) | Supplementary information
Placental-specific IGF-II is a major modulator of placental and fetal growth p945
Miguel Constância, Myriam Hemberger, Jennifer Hughes, Wendy Dean, Anne Ferguson-Smith, Reinald Fundele, Francesca Stewart, Gavin Kelsey, Abigail Fowden, Colin Sibley and Wolf Reik
doi:10.1038/nature00819
First paragraph | Full Text | PDF (255K)
See also: News and Views by Tycko & Efstratiadis
Mutations of the BRAF gene in human cancer p949
Helen Davies, Graham R. Bignell, Charles Cox, Philip Stephens, Sarah Edkins, Sheila Clegg, Jon Teague, Hayley Woffendin, Mathew J. Garnett, William Bottomley, Neil Davis, Ed Dicks, Rebecca Ewing, Yvonne Floyd, Kristian Gray, Sarah Hall, Rachel Hawes, Jaime Hughes, Vivian Kosmidou, Andrew Menzies, Catherine Mould, Adrian Parker, Claire Stevens, Stephen Watt, Steven Hooper, Rebecca Wilson, Hiran Jayatilake, Barry A. Gusterson, Colin Cooper, Janet Shipley, Darren Hargrave, Katherine Pritchard-Jones, Norman Maitland, Georgia Chenevix-Trench, Gregory J. Riggins, Darell D. Bigner, Giuseppe Palmieri, Antonio Cossu, Adrienne Flanagan, Andrew Nicholson, Judy W. C. Ho, Suet Y. Leung, Siu T. Yuen, Barbara L. Weber, Hilliard F. Seigler, Timothy L. Darrow, Hugh Paterson, Richard Marais, Christopher J. Marshall, Richard Wooster, Michael R. Stratton and P. Andrew Futreal
doi:10.1038/nature00766
First paragraph | Full Text | PDF (349K) | Supplementary information
See also: News and Views by Pollock & Meltzer
VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism p954
Hans-Peter Gerber, Ajay K. Malik, Gregg P. Solar, Daniel Sherman, Xiao Huan Liang, Gloria Meng, Kyu Hong, James C. Marsters and Napoleone Ferrara
doi:10.1038/nature00821
First paragraph | Full Text | PDF (345K)
A plant receptor-like kinase required for both bacterial and fungal symbiosis p959
Silke Stracke, Catherine Kistner, Satoko Yoshida, Lonneke Mulder, Shusei Sato, Takakazu Kaneko, Satoshi Tabata, Niels Sandal, Jens Stougaard, Krzysztof Szczyglowski and Martin Parniske
doi:10.1038/nature00841
First paragraph | Full Text | PDF (206K)
See also: News and Views by Spaink
A receptor kinase gene regulating symbiotic nodule development p962
Gabriella Endre, Attila Kereszt, Zoltán Kevei, Sorina Mihacea, Péter Kaló and György B. Kiss
doi:10.1038/nature00842
First paragraph | Full Text | PDF (776K) | Supplementary information
See also: News and Views by Spaink
A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis p967
François Dragon, Jennifer E. G. Gallagher, Patricia A. Compagnone-Post, Brianna M. Mitchell, Kara A. Porwancher, Karen A. Wehner, Steven Wormsley, Robert E. Settlage, Jeffrey Shabanowitz, Yvonne Osheim, Ann L. Beyer, Donald F. Hunt and Susan J. Baserga
doi:10.1038/nature00769
First paragraph | Full Text | PDF (301K) | Supplementary information
Structure of a bacterial quorum-sensing transcription factor complexed with pheromone and DNA p971
Rong-guang Zhang, Terina Pappas, Jennifer L. Brace, Paula C. Miller, Tim Oulmassov, John M. Molyneaux, John C. Anderson, James K. Bashkin, Stephen C. Winans and Andrzej Joachimiak
doi:10.1038/nature00833
First paragraph | Full Text | PDF (464K)
Structural basis for the recognition of hydroxyproline in HIF-1
by pVHL p975
Wai-Ching Hon, Michael I. Wilson, Karl Harlos, Timothy D. W. Claridge, Christopher J. Schofield, Christopher W. Pugh, Patrick H. Maxwell, Peter J. Ratcliffe, David I. Stuart and E. Yvonne Jones
doi:10.1038/nature00767
First paragraph | Full Text | PDF (351K) | Supplementary information
New on the Market
Detection, DNA, diagnostics p979
A selection of recent introductions including apoptosis detection kits.
doi:10.1038/417979a
