Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Genomic imprinting

Piece of cake

Knocking out a minor form of the Igf2 messenger RNA from the placenta in mice has surprisingly strong effects on nutrient transport to the fetus. This has implications for the theory of maternal–paternal genetic conflict.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Cross-section of the mouse placenta.

References

  1. Constância, M. et al. Nature 417, 945–948 (2002).

    Article  ADS  Google Scholar 

  2. Georgiades, P., Ferguson-Smith, A. C. & Burton, G. J. Placenta 23, 3–19 (2002).

    Article  CAS  Google Scholar 

  3. Efstratiadis, A. Int. J. Dev. Biol. 42, 955–976 (1998).

    CAS  Google Scholar 

  4. Moore, T. et al. Proc. Natl Acad. Sci. USA 94, 12509–12514 (1997).

    Article  ADS  CAS  Google Scholar 

  5. Constância, M. et al. Nature Genet. 26, 203–206 (2000).

    Article  Google Scholar 

  6. Nielson, F. C. et al. J. Biol. Chem. 265, 13431–13434 (1990).

    Google Scholar 

  7. Solter, D. Int. J. Dev. Biol. 42, 951–954 (1998).

    CAS  PubMed  Google Scholar 

  8. John, R. M. & Surani, M. A. Cell 101, 585–588 (2000).

    Article  CAS  Google Scholar 

  9. Haig, D. & Graham, C. Cell 64, 1045–1046 (1991).

    Article  CAS  Google Scholar 

  10. http://www.otago.ac.nz/IGC

  11. Frank, D. et al. Proc. Natl Acad. Sci. USA 99, 7490–7495 (2002).

    Article  ADS  CAS  Google Scholar 

  12. Hurst, L. D. & McVean, G. T. Curr. Opin. Genet. Dev. 8, 701–708 (1998).

    Article  CAS  Google Scholar 

  13. Gluckman, P. D. & Harding, J. E. Horm. Res. 48, 11–16 (1997).

    Article  CAS  Google Scholar 

  14. Smith, G. C. S. et al. Nature 417, 916 (2002).

    Article  ADS  CAS  Google Scholar 

  15. Lefebvre, L. et al. Nature Genet. 20, 163–169 (1998).

    Article  CAS  Google Scholar 

  16. Sapin, V. et al. Dev. Biol. 191, 29–39 (1997).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Benjamin Tycko or Argiris Efstratiadis.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tycko, B., Efstratiadis, A. Piece of cake. Nature 417, 913–914 (2002). https://doi.org/10.1038/417913a

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/417913a

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing