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Nature 417, 913-914 (27 June 2002) | doi:10.1038/417913a
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Gastroenterologist
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- Florida, USA
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- New York Structural Biology Center
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Genomic imprinting: Piece of cake
Benjamin Tycko & Argiris Efstratiadis
Abstract
Knocking out a minor form of the Igf2 messenger RNA from the placenta in mice has surprisingly strong effects on nutrient transport to the fetus. This has implications for the theory of maternal–paternal genetic conflict.
About 2,500 years ago, Anaxagoras (500–428 bc) was the first, or so the record indicates, to perceive that embryos receive nutriment through the navel. (Some of his contemporaries had bizarre notions, including the idea that the embryo is nourished through its whole body, like a sponge.
- Benjamin Tycko is at the Institute for Cancer Genetics and the Department of Pathology, and Argiris Efstratiadis is at the Institute for Cancer Genetics and the Department of Genetics and Development, Columbia University College of Physicians and Surgeons, 1150 St Nicholas Avenue, New York, New York 10032, USA.
Correspondence to: Benjamin Tycko e-mail: Email: bt12@columbia.edu
Email: arg@cancercenter.columbia.edu
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