Figures and Tables
From the following article:
VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism
Hans-Peter Gerber, Ajay K. Malik, Gregg P. Solar, Daniel Sherman, Xiao Huan Liang, Gloria Meng, Kyu Hong, James C. Marsters and Napoleone Ferrara
Nature 417, 954-958(27 June 2002)
doi:10.1038/nature00821
Figure 1
Real-time RT–PCR analysis of BMMNCs and HSCs and competitive repopulation frequencies of VEGF-deficient HSCs.
Full size figure and legend (72K)Figure 2
Comparison between the competitive repopulation of CD45.2-positive Sca+ Kit+ Linlo bone marrow cells deleted in both VEGF alleles (VEGFflox/flox) or control (VEGFlox/lox) cells 8 weeks after transplantation into lethally irradiated CD45.1-positive recipient mice.
Full size figure and legend (90K)Figure 3
VEGF inactivation by Flt–IgG interferes with the paracrine but not autocrine mechanism and small-molecule inhibitors targeting VEGFR-1 and -2 block both functions.
Full size figure and legend (60K)


