Table of contents
Volume 417 Number 6891 pp3-882
Naturejobs
ProspectsA sign of the times? p3
Paul Smaglik
doi:10.1038/nj6891-03a
POSTDOCS
Equal opportunities p5
Jan Schmollinger
doi:10.1038/nj6891-05a
movers
doi:10.1038/nj6891-99a
Opinion
Rethink anti-bioterrorism plans p773
With the US National Academies about to pronounce on science's role in counteracting bioterrorists, it falls on the Congress to oppose and restructure the domestic security framework proposed by the Bush administration.
doi:10.1038/417773a
News
US urged to provide smallpox vaccines for emergency crews p775
Erika Check
doi:10.1038/417775a
Senate adrift on cloning as talks break down p775
Erika Check
doi:10.1038/417775b
'Dirty bomb' scare prompts clampdown on lab security p776
Rex Dalton
doi:10.1038/417776a
Pentagon gets defensive over missile secrets p777
Geoff Brumfiel
doi:10.1038/417777a
Astronomers give virtual observatory a real future p777
Declan Butler
doi:10.1038/417777b
Drug researcher quits controversial cat study p778
Virginia Gewin
doi:10.1038/417778a
Draft cow genome heads the field p778
David Adam
doi:10.1038/417778b
Patent flurry casts cloud over gene silencing p779
Erika Check
doi:10.1038/417779a
news feature
Microfossils: Squaring up over ancient life p782
The textbooks say that oxygen-producing microorganisms evolved some 3.5 billion years ago. But as that claim and its author come under attack, the history of life on Earth may have to be rewritten. Rex Dalton investigates.
Rex Dalton
doi:10.1038/417782a
Mouse genetics: Full house p785
Across the world, animal facilities are overflowing with mutant mice. Jonathan Knight and Alison Abbott consider a logistical nightmare that is reaching crisis point, thanks to the revolution in genomics.
Jonathan Knight and Alison Abbott
doi:10.1038/417785a
Correspondence
Learning from past mistakes about nuclear waste p787
Any managing organization must be seen to be independent, transparent and legitimate.
Chris Murray
doi:10.1038/417787a
To sell science, find out what people want to buy p787
Till C. Jelitto
doi:10.1038/417787b
Macroecology: new, or biogeography revisited? p787
Howard J. Fisher
doi:10.1038/417787c
Online database could end taxonomic anarchy p787
Michael S. Y. Lee
doi:10.1038/417787d
Science's policy on access to private data p788
Donald Kennedy
doi:10.1038/417788a
Curiosity and generosity of a great scientist p788
Phillip J. Clapham
doi:10.1038/417788b
Health supercourse to end Arab isolation p788
Abdullatif Husseini, Rania Saad and Ronald E. LaPorte
doi:10.1038/417788c
Commentary
Is a bell tolling for Bell Labs? p789
It would be wise of Bell Labs to help others reproduce their scientists' results.
doi:10.1038/417789a
Book Reviews
Not waving but speaking p791
How important were gestures in the evolution of language?
Michael Tomasello reviews From Hand to Mouth: The Origins of Language by Michael C. Corballis
doi:10.1038/417791a
Life out of nowhere? p792
Paolo Mazzarello reviews Things Come to Life: Spontaneous Generation Revisited by Henry Harris
doi:10.1038/417792a
New Journals p792
doi:10.1038/417792b
Gases get cool p793
Keith Burnett reviews Lévy Statistics and Laser Cooling: How Rare Events Bring Atoms To Rest by François Bardou, Jean-Philippe Bouchaud, Alain Aspect and Claude Cohen-Tannoudji and Bose–Einstein Condensation in Dilute Gases by C. J. Pethick and H. Smith
doi:10.1038/417793a
Look back in amber p793
doi:10.1038/417793b
Science in culture p794
Michael John Gorman reviews
doi:10.1038/417794a
News and Views
Genome organization: Teamed up for transcription p797
In bacterial genomes, functionally related genes are often clustered and controlled as a unit. Such 'operons' are not normally found in animals — so why are they so abundant in one class of worm?
Christian von Mering and Peer Bork
doi:10.1038/417797a
Astronomy: Nebulous explanation p798
The planetary nebulae of gas and dust that are formed from red-giant stars are usually far from spherical in shape. Observations of the gas distribution in one red giant caught in the act of transition show why.
Mark Claussen
doi:10.1038/417798a
Physiology: Two ACEs and a heart p799
Cardiovascular diseases are some of the biggest killers in the developed world. The discovery of a new enzyme that affects cardiac function might provide fresh insight into heart disease.
Kenneth E. Bernstein
doi:10.1038/417799a
Zoology: New whale from old bones p801
John E. Heyning
doi:10.1038/417801a
Semiconductor technology: Imprints offer Moore p802
The cost of making chip components smaller using photolithographic printing might soon invalidate Moore's law. A new imprinting technique that can reproduce features as small as 10 nm could save it.
R. Fabian Pease
doi:10.1038/417802a
Neurobiology: Understanding the consequences p803
We learn in several ways, one of which involves forming an association between an action and its consequence. Studies of a marine mollusc shed light on how this creature forms a connection between biting and food.
Thomas J. Carew
doi:10.1038/417803a
100 and 50 years ago p805
doi:10.1038/417805a
Light microscopy: Beyond the diffraction limit? p806
The wave nature of light manifests itself in diffraction, which hampers attempts to determine the location of molecules. Clever use of microscopic techniques might now be circumventing the 'diffraction limit'.
Ernst H. K. Stelzer
doi:10.1038/417806a
Structural biology: A molecular propeller p807
Telomeres are protein–DNA structures protecting the ends of chromosomes. The crystal structure of a four-stranded stretch of human telomere DNA, bound to K+ ions, has implications for the design of anticancer drugs.
Dinshaw J. Patel
doi:10.1038/417807a
Daedalus: Cloud-chamber clouds p808
David Jones
doi:10.1038/417808a
Brief Communications
Bioacoustics: Only male fin whales sing loud songs p809
These mammals need to call long-distance when it comes to attracting females.
Donald A. Croll, Christopher W. Clark, Alejandro Acevedo, Bernie Tershy, Sergio Flores, Jason Gedamke and Jorge Urban
doi:10.1038/417809a
First paragraph | Full Text | PDF (127K)
Physiology: Dynamic instabilities in the inflating lung p809
Adriano M. Alencar,
Stephen P. Arold,
Sergey V. Buldyrev,
Arnab Majumdar,
Dimitrije Stamenovi
,
H. Eugene Stanley
and
Béla Suki
doi:10.1038/417809b
First paragraph | Full Text | PDF (127K)
Surface phenomena: Contact time of a bouncing drop p811
Denis Richard, Christophe Clanet and David Quéré
doi:10.1038/417811a
First paragraph | Full Text | PDF (170K)
Evolutionary biology: Hedgehog crosses the snail's midline p811
Alexander J. Nederbragt, André E. van Loon and Wim J. A. G. Dictus
doi:10.1038/417811b
First paragraph | Full Text | PDF (170K)
Review
Ordered porous materials for emerging applications p813
Mark E. Davis
doi:10.1038/nature00785
Abstract | Full Text | PDF (433K)
Article
Angiotensin-converting enzyme 2 is an essential regulator of heart function p822
Michael A. Crackower, Renu Sarao, Gavin Y. Oudit, Chana Yagil, Ivona Kozieradzki, Sam E. Scanga, Antonio J. Oliveira-dos-Santos, Joan da Costa, Liyong Zhang, York Pei, James Scholey, Carlos M. Ferrario, Armen S. Manoukian, Mark C. Chappell, Peter H. Backx, Yoram Yagil and Josef M. Penninger
doi:10.1038/nature00786
Abstract | Full Text | PDF (701K) | Supplementary information
See also: Commentary by Grant
Letters to Nature
A collimated jet of molecular gas from a star on the asymptotic giant branch p829
Hiroshi Imai, Kumiko Obara, Philip J. Diamond, Toshihiro Omodaka and Tetsuo Sasao
doi:10.1038/nature00788
First paragraph | Full Text | PDF (292K)
See also: News and Views by Claussen
Hidden orbital order in the heavy fermion metal URu2Si2 p831
P. Chandra, P. Coleman, J. A. Mydosh and V. Tripathi
doi:10.1038/nature00795
First paragraph | Full Text | PDF (319K)
Ultrafast and direct imprint of nanostructures in silicon p835
Stephen Y. Chou, Chris Keimel and Jian Gu
doi:10.1038/nature00792
First paragraph | Full Text | PDF (254K)
See also: News and Views by Pease
Growth of early continental crust controlled by melting of amphibolite in subduction zones p837
Stephen Foley, Massimo Tiepolo and Riccardo Vannucci
doi:10.1038/nature00799
First paragraph | Full Text | PDF (185K)
Paired gill slits in a fossil with a calcite skeleton p841
Patrício Dominguez, Antone G. Jacobson and Richard P. S. Jefferies
doi:10.1038/nature00805
First paragraph | Full Text | PDF (347K) | Supplementary information
Positive interactions among alpine plants increase with stress p844
Ragan M. Callaway, R. W. Brooker, Philippe Choler, Zaal Kikvidze, Christopher J. Lortie, Richard Michalet, Leonardo Paolini, Francisco I. Pugnaire, Beth Newingham, Erik T. Aschehoug, Cristina Armas, David Kikodze and Bradley J. Cook
doi:10.1038/nature00812
First paragraph | Full Text | PDF (226K) | Supplementary information
Consumer versus resource control of species diversity and ecosystem functioning p848
Boris Worm, Heike K. Lotze, Helmut Hillebrand and Ulrich Sommer
doi:10.1038/nature00830
First paragraph | Full Text | PDF (186K)
A global analysis of Caenorhabditis elegans operons p851
Thomas Blumenthal, Donald Evans, Christopher D. Link, Alessandro Guffanti, Daniel Lawson, Jean Thierry-Mieg, Danielle Thierry-Mieg, Wei Lu Chiu, Kyle Duke, Moni Kiraly and Stuart K. Kim
doi:10.1038/nature00831
First paragraph | Full Text | PDF (389K) | Supplementary information
See also: News and Views by von Mering & Bork
Feedback inhibition controls spike transfer in hybrid thalamic circuits p854
Gwendal Le Masson, Sylvie Renaud-Le Masson, Damien Debay and Thierry Bal
doi:10.1038/nature00825
First paragraph | Full Text | PDF (858K)
Na+/H+ exchanger regulatory factor 2 directs parathyroid hormone 1 receptor signalling p858
Matthew J. Mahon, Mark Donowitz, C. Chris Yun and Gino V. Segre
doi:10.1038/nature00816
First paragraph | Full Text | PDF (272K)
TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2 p861
Manolis Pasparakis, Gilles Courtois, Martin Hafner, Marc Schmidt-Supprian, Arianna Nenci, Atiye Toksoy, Monika Krampert, Matthias Goebeler, Reinhard Gillitzer, Alain Israel, Thomas Krieg, Klaus Rajewsky and Ingo Haase
doi:10.1038/nature00820
First paragraph | Full Text | PDF (921K) | Supplementary information
Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours p867
Angeliki Malliri, Rob A. van der Kammen, Kristopher Clark, Maarten van der Valk, Frits Michiels and John G. Collard
doi:10.1038/nature00848
First paragraph | Full Text | PDF (532K) | Supplementary information
Efp targets 14-3-3
for proteolysis and promotes breast tumour growth p871
Tomohiko Urano, Tomoyuki Saito, Tohru Tsukui, Masayo Fujita, Takayuki Hosoi, Masami Muramatsu, Yasuyoshi Ouchi and Satoshi Inoue
doi:10.1038/nature00826
First paragraph | Full Text | PDF (445K)
Crystal structure of parallel quadruplexes from human telomeric DNA p876
Gary N. Parkinson, Michael P. H. Lee and Stephen Neidle
doi:10.1038/nature755
First paragraph | Full Text | PDF (486K) | Supplementary information
See also: News and Views by Patel
corrigendum: MEC-2 regulates C. elegans DEG/ENaC channels needed for mechanosensation p880
M. B. Goodman, G. G. Ernstrom, D. S. Chelur, R. O'Hagan, C. A. Yao and M. Chalfie
doi:10.1038/nature00853
New on the Market
Going soft p881
The best thing since chalk, and updates of the usual software suspects.
doi:10.1038/417881a