Table of contents
Volume 417 Number 6890 pp3-772
Naturejobs
ProspectsA question of balance p3
Paul Smaglik
doi:10.1038/nj6890-03a
Special Report
Science and business p4
Around the world, universities are starting to encourage entrepreneurship among science students. Steve Bunk investigates.
Steve Bunk
doi:10.1038/nj6890-04a
Opinion
Distasteful but necessary p673
The public must be told that experiments on primates remain essential for progress in some areas of biomedicine. But the scientists involved should also lead the way in pressing for improvements in animal welfare.
doi:10.1038/417673a
Pay or train to publish? p673
China's authorities place too much emphasis on the former and too little on the latter.
doi:10.1038/417673b
News
Homeland security plan sparks fears for fight against bioterror p675
Geoff Brumfiel
doi:10.1038/417675a
US set to rejoin international fusion project p676
Geoff Brumfiel
doi:10.1038/417676a
Detectors licked by gummy fingers p676
David Cyranoski
doi:10.1038/417676b
France wires up to treat obsessive disorder p677
Sally Goodman
doi:10.1038/417677a
Statistical error leaves pollution data up in the air p677
Jonathan Knight
doi:10.1038/417677b
Science centres struggle as funds run out p678
David Adam
doi:10.1038/417678a
Environment institute slammed over 'selective' results p678
Johanna Schwarz and Alison Abbott
doi:10.1038/417678b
Argentine crisis rattles cosmic-ray hunters p679
Carol Marzuola
doi:10.1038/417679a
Mummy's silence broken at last p679
Rex Dalton
doi:10.1038/417679b
news feature
Chinese science: Plugging the brain drain p683
China produces fine scientists, but too many go abroad for training and do not return. David Cyranoski visits a programme that aims to give scientific high-fliers a reason to stay put.
David Cyranoski
doi:10.1038/417683a
Animal experiments: The great primate debate p684
When can invasive experiments on monkeys or apes be justified? And what would be the consequences for biomedical research if they were to cease? Sally Goodman and Erika Check pose some difficult questions.
Sally Goodman and Erika Check
doi:10.1038/417684a
Correspondence
Data security is crucial for Japanese science p689
Rules that are based solely on voluntary guidelines will not gain the trust of the public.
Eitaka Tsuboi, Norie Kawahara, Tadahiro Mitsuishi, Akira Oshima and Shohei Yonemoto
doi:10.1038/417689a
Collaboration can work if inequality is recognized p689
Yehuda Tzfati
doi:10.1038/417689b
Scientific links support an unjust peace process p689
Rita Giacaman
doi:10.1038/417689c
Did an academic boycott help to end apartheid? p690
George Fink
doi:10.1038/417690a
Violence versus freedom p690
Joel Bigman
doi:10.1038/417690b
In support of scientific exchange p690
Arjuna Aluwihare,
Claude Cohen-Tannoudji,
Ayse Erzan,
François Jacob,
John Polanyi,
Pieter van Dijk,
Edoardo Vesentini,
Torsten Wiesel
and
Contact:
Carol Corillon,
doi:10.1038/417690c
Book Reviews
My synapses, myself p691
Do our synaptic connections make us who we are?
William Calvin reviews Synaptic Self: How Our Brains Become Who We Are by Joseph LeDoux
doi:10.1038/417691a
A complete history of astronomy p692
Giovanni F. Bignami reviews Storia dell'astronomia: dalle origini al duemila e oltre by Giacomo Leopardi and Margherita Hack
doi:10.1038/417692a
Portraits of our family tree p692
Jacopo Moggi-Cecchi reviews The Human Fossil Record. Volume 1: Terminology and Craniodental Morphology of Genus Homo (Europe) by Jeffrey Schwartz and Ian Tattersall
doi:10.1038/417692b
Winning the numbers game p693
W. Timothy Gowers reviews The Honors Class: Hilbert's Problems and Their Solvers by Benjamin H. Yandell
doi:10.1038/417693a
Marine masterpieces p693
doi:10.1038/417693b
concepts
Global public goods: Health is wealth p695
Richard G. A. Feachem and Carol A. Medlin
doi:10.1038/417695a
News and Views
Planetary science: Rocks that go bump in the night p697
The planets were probably created by collisions between smaller rocky bodies over many millions of years. The identification of a recently formed asteroid family will tell us much about the dynamics of these collisions.
Derek C. Richardson
doi:10.1038/417697a
Ecology: Density and diversity p698
One explanation for the especially rich diversity of trees in the tropics is that a process called 'density-dependent mortality' operates there. It turns out, however, that this process occurs in temperate forests too.
Hans ter Steege and Roderick Zagt
doi:10.1038/417698a
Cardiovascular biology: A cholesterol tether p699
The build-up of cholesterol in the walls of arteries is a hallmark of atherosclerosis. Work with transgenic mice has revealed a specific interaction through which cholesterol deposition is initiated.
Bart Staels
doi:10.1038/417699a
Nanotechnology: Electronics and the single atom p701
The invention of semiconductor transistors in the 1940s revolutionized electronic circuitry. In the new world of 'nanoelectronics', a transistor whose active component is a single atom has now been demonstrated.
Silvano De Franceschi and Leo Kouwenhoven
doi:10.1038/417701a
Cell motility: The attraction of lipids p702
Cells often need to move up a concentration gradient of an attractive chemical. The types of lipids in the cell membranes also seem to form a gradient, from front to back of the cell. New work has identified two enzymes that may shape this lipid imbalance.
Amanda Tromans
doi:10.1038/417702a
Physiology: Haemoglobin's chaperone p703
Molecular chaperones come in different forms, but all have a similar task: to keep other proteins in shape. A newly identified chaperone seems to be specific to haemoglobin, preventing precipitation.
Lucio Luzzatto and Rosario Notaro
doi:10.1038/417703a
100 and 50 years ago p703
doi:10.1038/417703b
Daedalus: Collimated gas p705
David Jones
doi:10.1038/417705a
Obituary: Stephen Jay Gould (1941–2002) p706
Palaeontologist and public face of evolutionary biology
Derek E. G. Briggs
doi:10.1038/417706a
Brief Communications
Enantiostyly: Solving the puzzle of mirror-image flowers p707
The genetically controlled orientation of floral sex organs encourages cross-pollination.
Linley K. Jesson and Spencer C. H. Barrett
doi:10.1038/417707a
Tropical agriculture: The value of bees to the coffee harvest p708
David W. Roubik
doi:10.1038/417708a
First paragraph | Full Text | PDF (37K)
Progress
Architecture for a large-scale ion-trap quantum computer p709
D. Kielpinski, C. Monroe and D. J. Wineland
doi:10.1038/nature00784
Abstract | Full Text | PDF (154K)
Article
Crystal structure of a bacterial RNA polymerase holoenzyme at 2.6 Å resolution p712
Dmitry G. Vassylyev, Shun-ichi Sekine, Oleg Laptenko, Jookyung Lee, Marina N. Vassylyeva, Sergei Borukhov and Shigeyuki Yokoyama
doi:10.1038/nature752
Abstract | Full Text | PDF (1,147K) | Supplementary information
Letters to Nature
The recent breakup of an asteroid in the main-belt region p720
David Nesvorný, William F. Bottke Jr, Luke Dones and Harold F. Levison
doi:10.1038/nature00789
First paragraph | Full Text | PDF (645K)
See also: News and Views by Richardson
Coulomb blockade and the Kondo effect in single-atom transistors p722
Jiwoong Park, Abhay N. Pasupathy, Jonas I. Goldsmith, Connie Chang, Yuval Yaish, Jason R. Petta, Marie Rinkoski, James P. Sethna, Héctor D. Abruña, Paul L. McEuen and Daniel C. Ralph
doi:10.1038/nature00791
First paragraph | Full Text | PDF (340K)
See also: News and Views by De Franceschi & Kouwenhoven
Kondo resonance in a single-molecule transistor p725
Wenjie Liang, Matthew P. Shores, Marc Bockrath, Jeffrey R. Long and Hongkun Park
doi:10.1038/nature00790
First paragraph | Full Text | PDF (291K)
See also: News and Views by De Franceschi & Kouwenhoven
Mycorrhizal weathering of apatite as an important calcium source in base-poor forest ecosystems p729
Joel D. Blum, Andrea Klaue, Carmen A. Nezat, Charles T. Driscoll, Chris E. Johnson, Thomas G. Siccama, Christopher Eagar, Timothy J. Fahey and Gene E. Likens
doi:10.1038/nature00793
First paragraph | Full Text | PDF (177K)
Density-dependent mortality and the latitudinal gradient in species diversity p732
Janneke Hille Ris Lambers, James S. Clark and Brian Beckage
doi:10.1038/nature00809
First paragraph | Full Text | PDF (338K)
See also: News and Views by ter Steege & Zagt
Geographic structure and dynamics of coevolutionary selection p735
John N. Thompson and Bradley M. Cunningham
doi:10.1038/nature00810
First paragraph | Full Text | PDF (338K)
Spike train dynamics predicts theta-related phase precession in hippocampal pyramidal cells p738
Kenneth D. Harris, Darrell A. Henze, Hajime Hirase, Xavier Leinekugel, George Dragoi, Andras Czurkó and György Buzsáki
doi:10.1038/nature00808
First paragraph | Full Text | PDF (1,175K) | Supplementary information
Role of experience and oscillations in transforming a rate code into a temporal code p741
M. R. Mehta, A. K. Lee and M. A. Wilson
doi:10.1038/nature00807
First paragraph | Full Text | PDF (439K) | Supplementary information
Modulation of virulence within a pathogenicity island in vancomycin-resistant Enterococcus faecalis p746
Nathan Shankar, Arto S. Baghdayan and Michael S. Gilmore
doi:10.1038/nature00802
First paragraph | Full Text | PDF (307K) | Supplementary information
Subendothelial retention of atherogenic lipoproteins in early atherosclerosis p750
Kristina Skålén, Maria Gustafsson, Ellen Knutsen Rydberg, Lillemor Mattsson Hultén, Olov Wiklund, Thomas L. Innerarity and Jan Borén
doi:10.1038/nature00804
First paragraph | Full Text | PDF (190K)
See also: News and Views by Staels
T-box gene tbx5 is essential for formation of the pectoral limb bud p754
Dae-gwon Ahn, Matthew J. Kourakis, Laurel A. Rohde, Lee M. Silver and Robert K. Ho
doi:10.1038/nature00814
First paragraph | Full Text | PDF (372K) | Supplementary information
An abundant erythroid protein that stabilizes free 
-haemoglobin p758
Anthony J. Kihm, Yi Kong, Wei Hong, J. Eric Russell, Susan Rouda, Kazuhiko Adachi, M. Celeste Simon, Gerd A. Blobel and Mitchell J. Weiss
doi:10.1038/nature00803
First paragraph | Full Text | PDF (421K) | Supplementary information
See also: News and Views by Luzzatto & Notaro
Regulation of Arabidopsis cryptochrome 2 by blue-light-dependent phosphorylation p763
Dror Shalitin, Hongyun Yang, Todd C. Mockler, Maskit Maymon, Hongwei Guo, Garry C. Whitelam and Chentao Lin
doi:10.1038/nature00815
First paragraph | Full Text | PDF (334K)
Structure of the SRP19–RNA complex and implications for signal recognition particle assembly p767
Tobias Hainzl, Shenghua Huang and A. Elisabeth Sauer-Eriksson
doi:10.1038/nature00768
First paragraph | Full Text | PDF (371K)
New on the Market
Microscopic detail p772
Microscopes and their accessories.
doi:10.1038/417772a
