Analysis
Nature 417, 399-403 (23 May 2002) | doi:10.1038/nature750; Received 27 February 2002; Accepted 17 April 2002; Published online 8 May 2002
Comparative assessment of large-scale data sets of protein–protein interactions
Christian von Mering1, Roland Krause2, Berend Snel1, Michael Cornell3, Stephen G. Oliver3, Stanley Fields4 and Peer Bork1
Abstract
Comprehensive protein–protein interaction maps promise to reveal many aspects of the complex regulatory network underlying cellular function. Recently, large-scale approaches have predicted many new protein interactions in yeast. To measure their accuracy and potential as well as to identify biases, strengths and weaknesses, we compare the methods with each other and with a reference set of previously reported protein interactions.
- European Molecular Biology Laboratory, Meyerhofstrasse 1, 69012 Heidelberg, Germany
- Cellzome AG, Meyerhofstrasse 1, 69117 Heidelberg, Germany
- School of Biological Sciences, University of Manchester, 2.205 Stopford Building, Oxford Road, Manchester M13 9PT, UK
- Departments of Genome Sciences and Medicine, Howard Hughes Medical Institute, University of Washington, Box 357730, Seattle, Washington 98195, USA
Correspondence to: Peer Bork1 Correspondence and requests for materials should be addressed to P.B. (e-mail: Email: bork@embl-heidelberg.de).