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Nature 417, 238-239 (16 May 2002) | doi:10.1038/417238a

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Ion channels: How to be desensitized

Christian Rosenmund & Michael Mansour

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The various functional states of glutamate receptors control much of the brain's neuronal activity. Our understanding of how one of those states — desensitization — occurs has taken a leap forward.

Neurons communicate with each other through synapses, which operate in the following way. On one side of the synapse, the incoming neuron converts electrical activity, encoded in action potentials, into a chemical signal by releasing a neurotransmitter.

  1. Christian Rosenmund and Michael Mansour are in the Department of Membrane Biophysics, Max-Planck-Institute for Biophysical Chemistry, D-37077 Göttingen, Germany.

Correspondence to: Christian Rosenmund e-mail: Email: crosenm@gwdg.de