Figures and Tables
From the following article:
Mechanism of glutamate receptor desensitization
Yu Sun, Rich Olson, Michelle Horning, Neali Armstrong, Mark Mayer and Eric Gouaux
Nature 417, 245-253(16 May 2002)
doi:10.1038/417245a
Figure 1
The L483Y mutation and CTZ promote dimerization and block desensitization.
Full size figure and legend (60K)
Figure 2
The L483Y mutation and CTZ stabilize the GluR2 S1S2J dimer.
Full size figure and legend (163K)
Figure 3
Disruption of the Tyr 483 binding site at the dimer interface increases the extent of receptor desensitization and shifts the S1S2J monomer–dimer equilibrium towards monomer.
Full size figure and legend (52K)
Figure 4
Introduction of aspartate at position 754 accelerates desensitization and reveals a new, 'lateral' mode by which the ligand-binding cores can interact.
Full size figure and legend (59K)
Figure 5
Agonist-induced conformational changes in the dimer and gating model.
Full size figure and legend (125K)
Table 1
Dimer dissociation measurements and functional analysis of desensitization
Full size table and legend