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Nature 417, 95-98 (2 May 2002) | doi:10.1038/417095a;
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HIV preferentially infects HIV-specific CD4|[plus]| T cells
HIV infection is associated with the progressive loss of CD4|[plus]| T cells through their destruction or decreased production. A central, yet unresolved issue of HIV disease is the mechanism for this loss, and in particular whether HIV-specific CD4|[plus]| T cells are preferentially affected.
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