Table of contents
Volume 416 Number 6880 pp3-566
Naturejobs
ProspectsFrench disconnection p3
Paul Smaglik
doi:10.1038/nj6880-03a
Careers and Recruitment
Tearing down the barriers p4
In the fight against tumours, comprehensive cancer institutes are deploying a wide range of different strategies in an attempt to encourage the sharing of ideas and materials among researchers, says Steve Bunk.
Steve Bunk
doi:10.1038/nj6880-04a
Opinion
Media studies for scientists p461
Science, with its inherent uncertainties, can be hard to put across to the public. But blaming 'sloppy' journalism is too easy. If researchers are to make their points effectively, they should learn more about how the media work.
doi:10.1038/416461a
Prevention remains the best medicine p461
For the foreseeable future, smoking will kill more people than cancer researchers can hope to cure.
doi:10.1038/416461b
News
Papers square up over potential Pulitzer for cancer-centre critics p463
Erika Check
doi:10.1038/416463a
Foresters cautious over transgenics p463
Virginia Gewin
doi:10.1038/416463b
Online tumour bank aims to offer ready route to tissues p464
David Adam
doi:10.1038/416464a
Charity launches not-for-profit drug industry p465
Declan Butler
doi:10.1038/416465a
Putin reads science the riot act p465
Bryon MacWilliams
doi:10.1038/416465b
Sparks fly as electrostatic facility fizzles out p466
Declan Butler
doi:10.1038/416466a
US physicists unite behind big ideas p466
Geoff Brumfiel
doi:10.1038/416466b
University research to touch base with NASA p467
Tony Reichhardt
doi:10.1038/416467a
news feature
Cancer research: On the offensive p470
After decades of disappointment, and the investment of billions of dollars, is the 'war on cancer' about to gain real momentum? Alison Abbott sends a dispatch from the front line.
Alison Abbott
doi:10.1038/416470a
Correspondence
Miller revealed new ways to study the origins of life p475
Science advances as one theory builds on another: Miller didn't just update Löb's work.
Jeffrey L. Bada and Antonio Lazcano
doi:10.1038/416475a
Communication should not be left to scientists p475
Steve Fuller
doi:10.1038/416475b
Book Reviews
Making light work of computing p477
A lucid account of optical information-processing technology.
Ian Walmsley reviews Mind at Light Speed: A New Kind of Intelligence by David D. Nolte
doi:10.1038/416477a
Fixed ideas take root p478
Sharon R. Long reviews Nodulation in Legumes by Janet I. Sprent
doi:10.1038/416478a
Winged wonders p478
doi:10.1038/416478b
Lightning on the veld p478
John D. Hey reviews Schonland: Scientist and Soldier by Brian Austin
doi:10.1038/416478c
correction: A dark side of automation p479
doi:10.1038/416479a
concepts
Toxicology: A risky business p481
Toxicology research should urgently appraise its performance and join mainstream biomedical science.
Marcello Lotti and Pierluigi Nicotera
doi:10.1038/416481a
News and Views
Medicine: Danger — misfolding proteins p483
Protein folding is vital to living organisms because it adds functional flesh to the bare bones of genes. But errors in this process generate misfolded structures that can be lethal.
R. John Ellis and Teresa J. T. Pinheiro
doi:10.1038/416483a
Astrophysics: The evidence in the afterglow p484
The X-ray spectrum of an afterglow from a 
-ray burst reveals a smoking gun. It links the -rays to the expanding fireball that occurs after a supernova explosion.
Herman L. Marshall
doi:10.1038/416484a
Stem cells: Cell fusion causes confusion p485
'Transdifferentiation' is a poorly understood process invoked to explain how tissue-specific adult stem cells can generate cells of other tissues. New results challenge its existence.
Andrew E. Wurmser and Fred H. Gage
doi:10.1038/416485a
100 and 50 years ago p488
doi:10.1038/416488a
Biogeography: Baffled over bison p488
Two centuries ago, bison and elk were more common to the east of North America's Rocky Mountains than to the west. A look into why this was so may hold lessons for modern conservation biologists.
Peter D. Moore
doi:10.1038/416488b
Telecommunications: A boost for fibre optics p489
A possible solution to the need to expand fibre-optic capacities presents itself in the form of a new way of amplifying the information-carrying light transmissions. But turning principle into practice will require more work.
Z. Valy Vardeny
doi:10.1038/416489a
Genetics: Immaculate misconception p491
In mammals, mother and father make an equal genetic, but an unequal 'epigenetic', contribution to offspring. Studies of humans and mice with no maternal epigenetic contribution reveal more about this asymmetry.
M. A. Surani
doi:10.1038/416491a
Developmental biology: The plastic face p493
In vertebrates, the face is formed in part by neural crest cells. It has been assumed that the developmental fate of these cells is inbuilt. New work, however, reveals a role for instructive signals from nearby cells.
Massimo Pasqualetti and Filippo M. Rijli
doi:10.1038/416493a
Daedalus: Wave to the Sun p494
David Jones
doi:10.1038/416494a
Brief Communications
Microfabrication technology: Organized assembly of carbon nanotubes p495
Cunning refinements help to customize the architecture of nanotube structures.
B. Q. Wei, R. Vajtai, Y. Jung, J. Ward, R. Zhang, G. Ramanath and P. M. Ajayan
doi:10.1038/416495a
First paragraph | Full Text | PDF (164K)
Sperm competition: Motility and the midpiece in primates p496
Matthew J. Anderson and Alan F. Dixson
doi:10.1038/416496a
First paragraph | Full Text | PDF (62K)
Aerosol formation: Atmospheric particles from organic vapours p497
Colin D. O'Dowd, Pasi Aalto, Kaarle Hmeri, Markku Kulmala and Thorsten Hoffmann
doi:10.1038/416497a
First paragraph | Full Text | PDF (100K)
Nanomechanics: Response of a strained semiconductor structure p498
Feng Liu, Paul Rugheimer, E. Mateeva, D. E. Savage and M. G. Lagally
doi:10.1038/416498a
First paragraph | Full Text | PDF (74K)
Review
An extensive network of coupling among gene expression machines p499
Tom Maniatis and Robin Reed
doi:10.1038/416499a
Abstract | Full Text | PDF (378K)
Article
Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases p507
Monica Bucciantini, Elisa Giannoni, Fabrizio Chiti, Fabiana Baroni, Lucia Formigli, Jesús Zurdo, Niccolò Taddei, Giampietro Ramponi, Christopher M. Dobson and Massimo Stefani
doi:10.1038/416507a
Abstract | Full Text | PDF (423K)
See also: News and Views by Ellis & Pinheiro
Letters to Nature
The signature of supernova ejecta in the X-ray afterglow of the 
-ray burst 011211 p512
J. N. Reeves, D. Watson, J. P. Osborne, K. A. Pounds, P. T. O'Brien, A. D. T. Short, M. J. L. Turner, M. G. Watson, K. O. Mason, M. Ehle and N. Schartel
doi:10.1038/416512a
First paragraph | Full Text | PDF (218K)
See also: News and Views by Marshall
Bunching of fractionally charged quasiparticles tunnelling through high-potential barriers p515
E. Comforti, Y. C. Chung, M. Heiblum, V. Umansky and D. Mahalu
doi:10.1038/416515a
First paragraph | Full Text | PDF (295K)
See also: News and Views by Marshall
Atomic-scale images of charge ordering in a mixed-valence manganite p518
Ch. Renner, G. Aeppli, B.-G. Kim, Yeong-Ah Soh and S.-W. Cheong
doi:10.1038/416518a
First paragraph | Full Text | PDF (436K)
Abiogenic formation of alkanes in the Earth's crust as a minor source for global hydrocarbon reservoirs p522
B. Sherwood Lollar, T. D. Westgate, J. A. Ward, G. F. Slater and G. Lacrampe-Couloume
doi:10.1038/416522a
First paragraph | Full Text | PDF (195K) | Supplementary information
Long-lived vortices as a mode of deep ventilation in the Greenland Sea p525
Jean-Claude Gascard, Andrew J. Watson, Marie-José Messias, K. Anders Olsson, Truls Johannessen and Knud Simonsen
doi:10.1038/416525a
First paragraph | Full Text | PDF (451K)
Fin development in a cartilaginous fish and the origin of vertebrate limbs p527
Mikiko Tanaka, Andrea Münsterberg, W. Gary Anderson, Alan R. Prescott, Neil Hazon and Cheryll Tickle
doi:10.1038/416527a
First paragraph | Full Text | PDF (415K) | Supplementary information
The cost of inbreeding in Arabidopsis p531
Carlos D. Bustamante, Rasmus Nielsen, Stanley A. Sawyer, Kenneth M. Olsen, Michael D. Purugganan and Daniel L. Hartl
doi:10.1038/416531a
First paragraph | Full Text | PDF (173K) | Supplementary information
Naturally secreted oligomers of amyloid 
protein potently inhibit hippocampal long-term potentiation in vivo p535
Dominic M. Walsh, Igor Klyubin, Julia V. Fadeeva, William K. Cullen, Roger Anwyl, Michael S. Wolfe, Michael J. Rowan and Dennis J. Selkoe
doi:10.1038/416535a
First paragraph | Full Text | PDF (547K)
See also: News and Views by Ellis & Pinheiro
A global disorder of imprinting in the human female germ line p539
Hannah Judson, Bruce E. Hayward, Eamonn Sheridan and David T. Bonthron
doi:10.1038/416539a
First paragraph | Full Text | PDF (268K) | Supplementary information
See also: News and Views by Surani
Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion p542
Naohiro Terada, Takashi Hamazaki, Masahiro Oka, Masanori Hoki, Diana M. Mastalerz, Yuka Nakano, Edwin M. Meyer, Laurence Morel, Bryon E. Petersen and Edward W. Scott
doi:10.1038/nature730
First paragraph | Full Text | PDF (278K) | Supplementary information
See also: News and Views by Wurmser & Gage
Changing potency by spontaneous fusion p545
Qi-Long Ying, Jennifer Nichols, Edward P. Evans and Austin G. Smith
doi:10.1038/nature729
First paragraph | Full Text | PDF (372K)
Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus p548
Jianhang Jia, Kazuhito Amanai, Gelin Wang, Jiong Tang, Bing Wang and Jin Jiang
doi:10.1038/nature733
First paragraph | Full Text | PDF (514K) | Supplementary information
DNMT1 and DNMT3b cooperate to silence genes in human cancer cells p552
Ina Rhee, Kurtis E. Bachman, Ben Ho Park, Kam-Wing Jair, Ray-Whay Chiu Yen, Kornel E. Schuebel, Hengmi Cui, Andrew P. Feinberg, Christoph Lengauer, Kenneth W. Kinzler, Stephen B. Baylin and Bert Vogelstein
doi:10.1038/416552a
First paragraph | Full Text | PDF (367K) | Supplementary information
Control of CpNpG DNA methylation by the KRYPTONITE histone H3 methyltransferase p556
James P. Jackson, Anders M. Lindroth, Xiaofeng Cao and Steven E. Jacobsen
doi:10.1038/nature731
First paragraph | Full Text | PDF (545K) | Supplementary information
p63 and p73 are required for p53-dependent apoptosis in response to DNA damage p560
Elsa R. Flores, Kenneth Y. Tsai, Denise Crowley, Shomit Sengupta, Annie Yang, Frank McKeon and Tyler Jacks
doi:10.1038/416560a
First paragraph | Full Text | PDF (537K) | Supplementary information
New on the Market
Tissue culture and cell manipulation p565
Culture media, culture flasks and tissue processors.
doi:10.1038/416565a
