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Nature 416, 491-493 (4 April 2002) | doi:10.1038/416491a
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Genetics: Immaculate misconception
M. A. Surani
Abstract
In mammals, mother and father make an equal genetic, but an unequal 'epigenetic', contribution to offspring. Studies of humans and mice with no maternal epigenetic contribution reveal more about this asymmetry.
William Harvey, an anatomist and personal physician to two kings of England, was taking a gamble when he proposed in 1651 that 'Ex ovo omnia' — 'everything comes from an egg'. It wasn't until much later that the mammalian egg, or oocyte, was first detected and Harvey was proved right: a whole organism can develop from this remarkable cell.
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