Table of contents
Volume 416 Number 6878 pp3-349
Naturejobs
ProspectsAn end to the Irish rover? p3
Paul Smaglik
doi:10.1038/nj6878-03a
regions
Ireland: Going green p4
Paul Smaglik
doi:10.1038/nj6878-04a
Opinion
Pursuing arrogant simplicities p247
Multidisciplinary research in biology requires the patience to distinguish untutored crassness from deceptively simple insights, and awareness from all participants of just how complex is even the simplest life-form.
doi:10.1038/416247a
In search of sound science p247
Quality standards for US federal research could be useful — but only if industry acts in good faith.
doi:10.1038/416247b
News
Concern mounts as US agencies face challenges to data quality p249
Tony Reichhardt
doi:10.1038/416249a
Grants for youth aim to revive 'dying' Russian science p249
Bryon MacWilliams
doi:10.1038/416249b
Evolution critics seek role for unseen hand in education p250
Trisha Gura
doi:10.1038/416250a
Missed US nomination leaves climate post up for grabs p251
Jim Giles
doi:10.1038/416251a
Breast-cancer survey sets screening age for women p251
Helen Pearson
doi:10.1038/416251b
Cash shortfall means time out for physicists p251
Geoff Brumfiel
doi:10.1038/416251c
US and Vietnam join forces to count cost of Agent Orange p252
David Cyranoski
doi:10.1038/416252a
Diplomats near pact in simmering debate over transgenic foods p252
Jim Giles
doi:10.1038/416252b
Sea scouts plan big splash for oceanography p253
Virginia Gewin
doi:10.1038/416253a
Jospin reaches out to researchers p253
Sally Goodman
doi:10.1038/416253b
news feature
Postgenomics: Harvard's melting pot p256
At a new genomics centre, ethologists are rubbing shoulders with computer scientists, chemists and mathematicians. Peter Aldhous visits a bold experiment in multidisciplinarity.
Peter Aldhous
doi:10.1038/416256a
Scientific publishing: Peer review, unmasked p258
The editorial review of scientific papers usually takes place behind closed doors, but could the process be improved by opening it up for all to see? Trisha Gura investigates.
Trisha Gura
doi:10.1038/416258a
Correspondence
Biotech remains unloved by the more informed p261
The media may be providing the message — but is anyone heeding the call?
Massimiano Bucchi and Federico Neresini
doi:10.1038/416261a
Nothing automatic about ion-channel structures p261
Roderick MacKinnon
doi:10.1038/416261b
Opportunities for women in science (Russia, 1912) p262
Daniel P. Todes
doi:10.1038/416262a
Job-seekers, be careful of what you're signing p262
Ken Larner
doi:10.1038/416262b
Book Reviews
Unsung heroes of the revolution p263
The people whose ideas laid the foundations for the information age.
Paul Peercy reviews The Chip: How Two Americans Invented the Microchip and Launched a Revolution by T. R. Reid and Go To: The Story of the Math Majors, Bridge Players, Engineers, Chess Wizards, Scientists and Iconoclasts Who Were the Hero Programmers of the Software Revolution by Steve Lohr
doi:10.1038/416263a
In the eye of the beholder p264
Ian Stewart reviews It Must Be Beautiful: Great Equations of Modern Science
doi:10.1038/416264a
A Renaissance world view p264
doi:10.1038/416264b
A milestone for a new millennium p265
Daniel Cohen reviews The Human Genome
doi:10.1038/416265a
Science in culture p265
Martin Kemp reviews
doi:10.1038/416265b
concepts
Biochemical ecology: How plants fight dirty p267
Plant–herbivore interactions are frequently described as an ongoing biochemical warfare that occurs on an evolutionary timescale.
Jack C. Schultz
doi:10.1038/416267a
News and Views
Planetary science: The north–south martian divide p269
Some of the differences between the northern and southern hemispheres of Mars may stem from asymmetry in the planet's atmospheric circulation, and the resulting distribution of water and dust.
Peter Gierasch
doi:10.1038/416269a
Neurobiology: Ready to unlearn p270
After rabbits learn to associate a tone with a small shock near the eye, they blink when they hear the tone. Learning requires activation of nerve fibres known as climbing fibres. Inhibition of these fibres leads to 'unlearning'.
Shigeru Kitazawa
doi:10.1038/416270a
100 and 50 years ago p271
doi:10.1038/416271a
Molecular physiology: Protecting the heart p273
Abnormal enlargement of the heart muscle can be life-threatening. Unexpected insight into the underlying molecular mechanisms has come from investigating a gene that regulates cardiac calcium levels.
Mark T. Nelson and Gerald M. Herrera
doi:10.1038/416273a
Materials science: Breaking the neural code p274
The precise information that is conveyed between nerve cells remains unknown. Networks of nerve cells grown on silicon chips, using a polyester as a guide, may bring us closer to translating the elusive neural language.
Adam Curtis
doi:10.1038/416274a
Immunology: The Wright stuff p275
White cells in the bloodstream seek out and destroy invading bacteria. The explanation for the actual killing mechanism turns out to be wonderfully more subtle than previously thought.
Walter Gratzer
doi:10.1038/416275a
Quantum optics: Light corralled p275
Liesbeth Venema
doi:10.1038/416275b
Daedalus: Fast forgetting p277
David Jones
doi:10.1038/416277a
Brief Communications
Biochemistry: Biosynthesis of an organofluorine molecule p279
A fluorinase enzyme has been discovered that catalyses carbon–fluorine bond formation.
David O'Hagan, Christoph Schaffrath, Steven L. Cobb, John T. G. Hamilton and Cormac D. Murphy
doi:10.1038/416279a
First paragraph | Full Text | PDF (54K)
Tumour biology: Herceptin acts as an anti-angiogenic cocktail p279
Yotaro Izumi, Lei Xu, Emmanuelle di Tomaso, Dai Fukumura and Rakesh K. Jain
doi:10.1038/416279b
First paragraph | Full Text | PDF (94K)
Hypothesis
The transorientation hypothesis for codon recognition during protein synthesis p281
Anne B. Simonson and James A. Lake
doi:10.1038/416281a
Abstract | Full Text | PDF (307K) | Supplementary information
Articles
Diurnal modulation of pacemaker potentials and calcium current in the mammalian circadian clock p286
Cyriel M. A. Pennartz, Marcel T. G. de Jeu, Nico P. A. Bos, Jeroen Schaap and Alwin M. S. Geurtsen
doi:10.1038/nature728
Abstract | Full Text | PDF (356K)
Killing activity of neutrophils is mediated through activation of proteases by K+ flux p291
Emer P. Reeves, Hui Lu, Hugues Lortat Jacobs, Carlo G. M. Messina, Steve Bolsover, Giorgio Gabella, Eric O. Potma, Alice Warley, Jürgen Roes and Anthony W. Segal
doi:10.1038/416291a
Abstract | Full Text | PDF (418K) | Supplementary information
See also: News and Views by Gratzer
Letters to Nature
A topographically forced asymmetry in the martian circulation and climate p298
Mark I. Richardson and R. John Wilson
doi:10.1038/416298a
First paragraph | Full Text | PDF (291K)
See also: News and Views by Gierasch
Ferromagnetism in one-dimensional monatomic metal chains p301
P. Gambardella, A. Dallmeyer, K. Maiti, M. C. Malagoli, W. Eberhardt, K. Kern and C. Carbone
doi:10.1038/416301a
First paragraph | Full Text | PDF (436K)
An ordered mesoporous organosilica hybrid material with a crystal-like wall structure p304
Shinji Inagaki, Shiyou Guan, Tetsu Ohsuna and Osamu Terasaki
doi:10.1038/416304a
First paragraph | Full Text | PDF (571K) | Supplementary information
Origin and fate of Lake Vostok water frozen to the base of the East Antarctic ice sheet p307
Robin E. Bell, Michael Studinger, Anahita A. Tikku, Garry K.C. Clarke, Michael M. Gutner and Chuck Meertens
doi:10.1038/416307a
First paragraph | Full Text | PDF (377K)
Development of anisotropic structure in the Earth's lower mantle by solid-state convection p310
Allen K. McNamara, Peter E. van Keken and Shun-Ichiro Karato
doi:10.1038/416310a
First paragraph | Full Text | PDF (1,472K)
A ceratopsian dinosaur from China and the early evolution of Ceratopsia p314
Xing Xu, Peter J. Makovicky, Xiao-lin Wang, Mark A. Norell and Hai-lu You
doi:10.1038/416314a
First paragraph | Full Text | PDF (305K) | Supplementary information
Remains of Homo erectus from Bouri, Middle Awash, Ethiopia p317
Berhane Asfaw, W. Henry Gilbert, Yonas Beyene, William K. Hart, Paul R. Renne, Giday WoldeGabriel, Elisabeth S. Vrba and Tim D. White
doi:10.1038/416317a
First paragraph | Full Text | PDF (461K) | Supplementary information
Genetic cost of reproductive assurance in a self-fertilizing plant p320
Christopher R. Herlihy and Christopher G. Eckert
doi:10.1038/416320a
First paragraph | Full Text | PDF (149K)
Reduced adaptation of a non-recombining neo-Y chromosome p323
Doris Bachtrog and Brian Charlesworth
doi:10.1038/416323a
First paragraph | Full Text | PDF (179K)
Dissecting the architecture of a quantitative trait locus in yeast p326
Lars M. Steinmetz, Himanshu Sinha, Dan R. Richards, Jamie I. Spiegelman, Peter J. Oefner, John H. McCusker and Ronald W. Davis
doi:10.1038/416326a
First paragraph | Full Text | PDF (294K) | Supplementary information
Inhibition of climbing fibres is a signal for the extinction of conditioned eyelid responses p330
Javier F. Medina, William L. Nores and Michael D. Mauk
doi:10.1038/416330a
First paragraph | Full Text | PDF (289K)
See also: News and Views by Kitazawa
Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy p334
Hong-Bo Xin, Takaaki Senbonmatsu, Dong-Sheng Cheng, Yong-Xiao Wang, Julio A. Copello, Guang-Ju Ji, Mei Lin Collier, Ke-Yu Deng, Loice H. Jeyakumar, Mark A. Magnuson, Tadashi Inagami, Michael I. Kotlikoff and Sidney Fleischer
doi:10.1038/416334a
First paragraph | Full Text | PDF (263K) | Supplementary information
See also: News and Views by Nelson & Herrera
Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms p337
Lili A. Barouch, Robert W. Harrison, Michel W. Skaf, Gisele O. Rosas, Thomas P. Cappola, Zoulficar A. Kobeissi, Ion A. Hobai, Christopher A. Lemmon, Arthur L. Burnett, Brian O'Rourke, E. Rene Rodriguez, Paul L. Huang, João A. C. Lima, Dan E. Berkowitz and Joshua M. Hare
doi:10.1038/416337a
First paragraph | Full Text | PDF (225K) | Supplementary information
The AID enzyme induces class switch recombination in fibroblasts p340
Il-mi Okazaki, Kazuo Kinoshita, Masamichi Muramatsu, Kiyotsugu Yoshikawa and Tasuku Honjo
doi:10.1038/nature727
First paragraph | Full Text | PDF (524K)
TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2 p345
Xiaoming Li, Yili Yang and Jonathan D. Ashwell
doi:10.1038/416345a
First paragraph | Full Text | PDF (345K) | Supplementary information
correction: Effects of experience and social context on prospective caching strategies by scrub jays p349
N. J. Emery and N. S. Clayton
doi:10.1038/416349a
erratum: Tyrannosaurus was not a fast runner p349
John R. Hutchinson and Mariano Garcia
doi:10.1038/416349b