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Nature 416, 133-136 (14 February 2002) | doi:10.1038/416133a
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John Innes Centre Project Leader in Plant or Microbial Sciences
- University of East Anglia
- Norwich, NR4 7TJ, UK
Assistant Editor – Nature Immunology
- Nature Publishing Group
- New York, NY United States
Signal transduction: Molecular ticket to enter cells
Shlomo Oved & Yosef Yarden
Abstract
Just as important as starting cellular signalling pathways is switching them off again. It seems that the Cbl protein has a dual function in accelerating the degradation of certain signalling molecules.
The cells that make up our bodies live in tight-knit communities and communicate with each other almost constantly. They often do so by using messenger molecules such as growth factors; when these molecules bind to receptors on the cell surface, they activate a plethora of cellular processes that set specific gene programmes in motion.
- Shlomo Oved and Yosef Yarden are in the Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel.
Correspondence to: Yosef Yarden e-mail: Email: yosef.yarden@weizmann.ac.il
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