Paul Smaglik
doi:10.1038/nj6872-03a
Table of contents
Volume 415 Number 6872 pp3-716
Top of page
Careers and Recruitment
Naturejobs
ProspectsSwings and roundabouts p3
Careers and Recruitment
A route to flexible working p4
Researchers who aspire to work in drug discovery need to adapt to constantly changing technology and be able to harness new tools both to ask and to answer pertinent scientific questions, say Paul Smaglik and Adam Smith.
Paul Smaglik and Adam Smith
doi:10.1038/nj6872-04a
Life beyond the walls p7
Many large drug companies are now taking advantage of the specialist skills offered by smaller biotech firms in their search for new drugs. This trend for outsourcing elements of research is forcing a careful evaluation of licensing policy, says Adam Smith.
Adam Smith
doi:10.1038/nj6872-07a
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Opinion
Awash with cash, bereft of leadership p561
The National Institutes of Health has been granted impressive funding increases, but its lack of a permanent director is getting beyond a joke. The sooner the Bush administration plugs this gap with an inspired leader, the better.
doi:10.1038/415561a
A troublesome ménage à trois p561
France's largest research agency is in need of reform — but so are the universities that host its labs.
doi:10.1038/415561b
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News
National audit slams CNRS over poor management and planning p563
Developing world gets patent aid p563
Bush goes to war as budget boosts R&D p564
Funding freeze leaves high-energy physics facing cuts p564
NASA tunes in to nuclear power p565
Extra duties offset NSF gains p565
Pentagon rise bypasses campuses p565
doi:10.1038/415565c
Peer-review programme is rewarded p565
doi:10.1038/415565d
Minority programmes win at NIH p565
doi:10.1038/415565e
Technology scheme under siege p565
doi:10.1038/415565f
German parliament backs stem-cell research p566
Drillers dig deep for microbes under the sea floor p566
Reviews spark debate over breast screening p567
Climate lobby group closes down p567
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news feature
Planetary portraits p570
The list of known planets outside our Solar System grows by the week. Thanks to new technologies, a host of pictures of these worlds could soon be available. Tony Reichhardt investigates.
Tony Reichhardt
doi:10.1038/415570a
All at sea p572
The oceans are full of microorganisms, which are thought to cycle nutrients and mediate climate on a global scale. Despite these environmental consequences, marine microbial biodiversity remains poorly understood. Jon Copley reports.
Jon Copley
doi:10.1038/415572a
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Correspondence
The 15% solution for majority health concerns p575
Medical journals should devote more space to issues that affect the developing world.
David A. Shaywitz and Dennis A. Ausiello
doi:10.1038/415575a
World hasn't changed for the dispossessed p575
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Commentary
Diagnostic testing fails the test p577
The pitfalls of patents are illustrated by the case of haemochromatosis.
Jon F. Merz, Antigone G. Kriss, Debra G. B. Leonard and Mildred K. Cho
doi:10.1038/415577a
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Book Reviews
The acceptable face of conservation p581
Wildlife conservation can bolster human needs rather than conflict with them.
doi:10.1038/415581a
A lament for Italy's brain drain p582
doi:10.1038/415582a
Weeds' watery ways p582
doi:10.1038/415582b
The answer lies in the soil p583
doi:10.1038/415583a
Warfare of a chemical kind p584
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words
Coming to terms p585
Caloric, cathode, curium and quark — coinage from the mint of science.
J. L. Heilbron
doi:10.1038/415585a
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News and Views
神経心理学：調子はずれの脳
Neuropsychology: Brains out of tune p589
Is lack of musical ability simply the result of failure to practise? Probably not, if new investigations are anything to go by. They show that a disorder akin to dyslexia affects the processing of pitch.
Thomas F. Münte
doi:10.1038/415589a
100 and 50 years ago p590
海洋微生物学：海に潜む光合成細菌
Microbiological oceanography: Hidden in a sea of microbes p590
The photosynthetic activities of bacteria in the oceans are more diverse than previously thought. A full picture of the marine energy budget will require their separate contributions to be teased apart.
David M. Karl
doi:10.1038/415590b
DNA修復：校正係はAPエンドヌクレアーゼ
DNA repair: An APE that proofreads p593
An enzyme involved in one aspect of DNA repair is now shown to have another function that improves the accuracy of repair. The new findings should help to improve therapies for HIV.
Josef Jiricny
doi:10.1038/415593a
粒状材料：温度を測る
Granular materials: Taking the temperature p594
The 'temperature' of a granular material depends on its entropy, but is hard to measure in the laboratory. So a theory that ties temperature to grain mobility and diffusion is welcome.
Bob Behringer
doi:10.1038/415594a
洋学：弱まる海洋循環
Oceanography: A slower flow p594
Daedalus: Perfect perforations p595
Obituary: Franco Rasetti (1901–2001) p597
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Brief Communications
Nanotechnology: Carbon nanothermometer containing gallium p599
Gallium's macroscopic properties are retained on a miniature scale in this nanodevice.
Yihua Gao and Yoshio Bando
doi:10.1038/415599a
Psychobiology: Speech sounds learned by sleeping newborns p599
M. Cheour, O. Martynova, R. Näätänen, R. Erkkola, M. Sillanpää, P. Kero, A. Raz, M.-L. Kaipio, J. Hiltunen, O. Aaltonen, J. Savela and H. Hämäläinen
doi:10.1038/415599b
Microstructures: Spin-engineering magnetic media p600
S. P. Li, W. S. Lew, J. A. C. Bland, L. Lopez-Diaz, M. Natali, C. A. F. Vaz and Y. Chen
doi:10.1038/415600a
Ecology (Communication arising): Is coral bleaching really adaptive? p601
Ove Hoegh-Guldberg, Ross J. Jones, Selina Ward and William K. Loh
doi:10.1038/415601a
Ecology (Communication arising): Is coral bleaching really adaptive? p602
erratum: Seeing through the face of deception p602
erratum: Laterality in tool manufacture by crows p602
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Articles
気候：太平洋上層における南北方向の鉛直循環の弱まり
Slowdown of the meridional overturning circulation in the upper Pacific Ocean p603
進化：仮想獲物の隠蔽色と多型性は視覚捕食者によって選択される
Visual predators select for crypticity and polymorphism in virtual prey p609
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Letters to Nature
物理：決定的な実験の数値モデルにより粒状物質に対する熱力学的アプローチを検証
Testing the thermodynamic approach to granular matter with a numerical model of a decisive experiment p614
物理：ナノスケールのフォトニクスと電子工学のためのナノワイヤ超格子構造の成長
Growth of nanowire superlattice structures for nanoscale photonics and electronics p617
Mark S. Gudiksen, Lincoln J. Lauhon, Jianfang Wang, David C. Smith and Charles M. Lieber
doi:10.1038/415617a
日本語要約 | Full Text | PDF (288K)
物理：球状の誘電微小空洞を利用する超低閾値のラマンレーザー
Ultralow-threshold Raman laser using a spherical dielectric microcavity p621
化学：担持型金属クラスターが触媒するアルケンの水素化におけるリガンド効果の観察
Observation of ligand effects during alkene hydrogenation catalysed by supported metal clusters p623
A. M. Argo, J. F. Odzak, F. S. Lai and B. C. Gates
doi:10.1038/415623a
環境：大気輸送モデルを利用してCO2放出量と吸収量の信頼できる地域別推定値をめざす
Towards robust regional estimates of CO2 sources and sinks using atmospheric transport models p626
Kevin Robert Gurney, Rachel M. Law, A. Scott Denning, Peter J. Rayner, David Baker, Philippe Bousquet, Lori Bruhwiler, Yu-Han Chen, Philippe Ciais, Songmiao Fan, Inez Y. Fung, Manuel Gloor, Martin Heimann, Kaz Higuchi, Jasmin John, Takashi Maki, Shamil Maksyutov, Ken Masarie, Philippe Peylin, Michael Prather, Bernard C. Pak, James Randerson, Jorge Sarmiento, Shoichi Taguchi, Taro Takahashi and Chiu-Wai Yuen
doi:10.1038/415626a
生態：好気性で酸素非発生型の海洋光合成細菌には予想外の多様性が見られる
Unsuspected diversity among marine aerobic anoxygenic phototrophs p630
Oded Béjà, Marcelino T. Suzuki, John F. Heidelberg, William C. Nelson, Christina M. Preston, Tohru Hamada, Jonathan A. Eisen, Claire M. Fraser and Edward F. DeLong
doi:10.1038/415630a
日本語要約 | Full Text | PDF (164K)
生態：シカの移住率と死亡率の性差が個体群の最適な管理に影響する
Sex differences in emigration and mortality affect optimal management of deer populations p633
T. H. Clutton-Brock, T. N. Coulson, E. J. Milner-Gulland, D. Thomson and H. M. Armstrong
doi:10.1038/415633a
日本語要約 | Full Text | PDF (275K)
視覚：光景に関する統計量が色恒常性に及ぼす影響
Influence of scene statistics on colour constancy p637
Early consolidation in human primary motor cortex p640
Wolf Muellbacher, Ulf Ziemann, Joerg Wissel, Nguyet Dang, Markus Kofler, Stefano Facchini, Babak Boroojerdi, Werner Poewe and Mark Hallett
doi:10.1038/nature712
遺伝：ゲノム・シャッフリング法は細菌の表現型を短時間で改良する
Genome shuffling leads to rapid phenotypic improvement in bacteria p644
Ying-Xin Zhang, Kim Perry, Victor A. Vinci, Keith Powell, Willem P. C. Stemmer and Stephen B. del Cardayré
doi:10.1038/415644a
細胞：シナプトブレビンが小胞で受けている制約から、膜融合にカルシウムが果たす役割が示唆される
Vesicular restriction of synaptobrevin suggests a role for calcium in membrane fusion p646
Kuang Hu, Joe Carroll, Sergei Fedorovich, Colin Rickman, Andrei Sukhodub and Bazbek Davletov
doi:10.1038/415646a
日本語要約 | Full Text | PDF (198K)
S-Cdk-dependent phosphorylation of Sld2 essential for chromosomal DNA replication in budding yeast p651
Hiroshi Masumoto, Sachiko Muramatsu, Yoichiro Kamimura and Hiroyuki Araki
doi:10.1038/nature713
First paragraph | Full Text | PDF (329K) | Supplementary information
生化学：3'-ミス対合DNAに対してヒトAP（脱プリン/ピリミジン）エンドヌクレアーゼが示すエキソヌクレアーゼ活性
An exonucleolytic activity of human apurinic/apyrimidinic endonuclease on 3' mispaired DNA p655
Kai-Ming Chou and Yung-Chi Cheng
doi:10.1038/415655a
細胞：骨格筋のミオシン頭部による力の発生機構
Mechanism of force generation by myosin heads in skeletal muscle p659
Gabriella Piazzesi, Massimo Reconditi, Marco Linari, Leonardo Lucii, Yin-Biao Sun, Theyencheri Narayanan, Peter Boesecke, Vincenzo Lombardi and Malcolm Irving
doi:10.1038/415659a
日本語要約 | Full Text | PDF (260K)
生理：RanGAPはアルギニンフィンガーを用いずGTP加水分解を仲介する
RanGAP mediates GTP hydrolysis without an arginine finger p662
Michael J. Seewald, Carolin Körner, Alfred Wittinghofer and Ingrid R. Vetter
doi:10.1038/415662a
erratum: Formation of coastline features by large-scale instabilities induced by high-angle waves p666
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introduction
review article
corporate support
insight
forewordmalaria p669
doi:10.1038/415669a
introduction
Malaria in 2002 p670
review article
The pathogenic basis of malaria p673
Louis H. Miller, Dror I. Baruch, Kevin Marsh and Ogobara K. Doumbo
doi:10.1038/415673a
The economic and social burden of malaria p680
Medical need, scientific opportunity and the drive for antimalarial drugs p686
Progress and challenges for malaria vaccines p694
Plasmodium, human and Anopheles genomics and malaria p702
Stephen L. Hoffman, G. Mani Subramanian, Frank H. Collins and J. Craig Venter
doi:10.1038/415702a
Satellite imagery in the study and forecast of malaria p710
David J. Rogers, Sarah E. Randolph, Robert W. Snow and Simon I. Hay
doi:10.1038/415710a
corporate support
The Medicines for Malaria Venture p715
Discovering developing and delivering new and affordable medicines for this deadly disease
Christopher C. Hentschel, PhD
doi:10.1038/415715a
GlaxoSmithKline & malaria p716
doi:10.1038/415716a
