Table of contents
Volume 415 Number 6872 pp3-716
Naturejobs
ProspectsSwings and roundabouts p3
Paul Smaglik
doi:10.1038/nj6872-03a
Careers and Recruitment
A route to flexible working p4
Researchers who aspire to work in drug discovery need to adapt to constantly changing technology and be able to harness new tools both to ask and to answer pertinent scientific questions, say Paul Smaglik and Adam Smith.
Paul Smaglik and Adam Smith
doi:10.1038/nj6872-04a
Life beyond the walls p7
Many large drug companies are now taking advantage of the specialist skills offered by smaller biotech firms in their search for new drugs. This trend for outsourcing elements of research is forcing a careful evaluation of licensing policy, says Adam Smith.
Adam Smith
doi:10.1038/nj6872-07a
Opinion
Awash with cash, bereft of leadership p561
The National Institutes of Health has been granted impressive funding increases, but its lack of a permanent director is getting beyond a joke. The sooner the Bush administration plugs this gap with an inspired leader, the better.
doi:10.1038/415561a
A troublesome ménage à trois p561
France's largest research agency is in need of reform — but so are the universities that host its labs.
doi:10.1038/415561b
News
National audit slams CNRS over poor management and planning p563
Sally Goodman
doi:10.1038/415563a
Developing world gets patent aid p563
Declan Butler
doi:10.1038/415563b
Bush goes to war as budget boosts R&D p564
Colin Macilwain
doi:10.1038/415564a
Funding freeze leaves high-energy physics facing cuts p564
Geoff Brumfiel
doi:10.1038/415564b
NASA tunes in to nuclear power p565
Tony Reichhardt
doi:10.1038/415565a
Extra duties offset NSF gains p565
Virginia Gewin
doi:10.1038/415565b
Pentagon rise bypasses campuses p565
doi:10.1038/415565c
Peer-review programme is rewarded p565
doi:10.1038/415565d
Minority programmes win at NIH p565
doi:10.1038/415565e
Technology scheme under siege p565
doi:10.1038/415565f
German parliament backs stem-cell research p566
Quirin Schiermeier
doi:10.1038/415566a
Drillers dig deep for microbes under the sea floor p566
Rex Dalton
doi:10.1038/415566b
Reviews spark debate over breast screening p567
Jonathan Knight
doi:10.1038/415567a
Climate lobby group closes down p567
Virginia Gewin
doi:10.1038/415567b
news feature
Planetary portraits p570
The list of known planets outside our Solar System grows by the week. Thanks to new technologies, a host of pictures of these worlds could soon be available. Tony Reichhardt investigates.
Tony Reichhardt
doi:10.1038/415570a
All at sea p572
The oceans are full of microorganisms, which are thought to cycle nutrients and mediate climate on a global scale. Despite these environmental consequences, marine microbial biodiversity remains poorly understood. Jon Copley reports.
Jon Copley
doi:10.1038/415572a
Correspondence
The 15% solution for majority health concerns p575
Medical journals should devote more space to issues that affect the developing world.
David A. Shaywitz and Dennis A. Ausiello
doi:10.1038/415575a
World hasn't changed for the dispossessed p575
Steve Drury
doi:10.1038/415575b
Commentary
Diagnostic testing fails the test p577
The pitfalls of patents are illustrated by the case of haemochromatosis.
doi:10.1038/415577a
Book Reviews
The acceptable face of conservation p581
Wildlife conservation can bolster human needs rather than conflict with them.
Brian Child reviews African Wildlife and Livelihoods: The Promise and Performance of Community Conservation
doi:10.1038/415581a
A lament for Italy's brain drain p582
Roberto Battiston reviews Cervelli in Fuga
doi:10.1038/415582a
Weeds' watery ways p582
doi:10.1038/415582b
The answer lies in the soil p583
David Schimel reviews Understanding Soil Change: Soil Sustainability over Millennia, Centuries, and Decades by Daniel D. Richter and Daniel Markewitz
doi:10.1038/415583a
Warfare of a chemical kind p584
Alastair Hay reviews War and Nature: Fighting Humans and Insects with Chemicals from World War I to Silent Spring by Edmund Russell
doi:10.1038/415584a
words
Coming to terms p585
Caloric, cathode, curium and quark — coinage from the mint of science.
J. L. Heilbron
doi:10.1038/415585a
News and Views
Neuropsychology: Brains out of tune p589
Is lack of musical ability simply the result of failure to practise? Probably not, if new investigations are anything to go by. They show that a disorder akin to dyslexia affects the processing of pitch.
Thomas F. Münte
doi:10.1038/415589a
100 and 50 years ago p590
doi:10.1038/415590a
Microbiological oceanography: Hidden in a sea of microbes p590
The photosynthetic activities of bacteria in the oceans are more diverse than previously thought. A full picture of the marine energy budget will require their separate contributions to be teased apart.
David M. Karl
doi:10.1038/415590b
DNA repair: An APE that proofreads p593
An enzyme involved in one aspect of DNA repair is now shown to have another function that improves the accuracy of repair. The new findings should help to improve therapies for HIV.
Josef Jiricny
doi:10.1038/415593a
Granular materials: Taking the temperature p594
The 'temperature' of a granular material depends on its entropy, but is hard to measure in the laboratory. So a theory that ties temperature to grain mobility and diffusion is welcome.
Bob Behringer
doi:10.1038/415594a
Oceanography: A slower flow p594
Heike Langenberg
doi:10.1038/415594b
Daedalus: Perfect perforations p595
David Jones
doi:10.1038/415595a
Obituary: Franco Rasetti (1901–2001) p597
Larkin Kerwin
doi:10.1038/415597a
Brief Communications
Nanotechnology: Carbon nanothermometer containing gallium p599
Gallium's macroscopic properties are retained on a miniature scale in this nanodevice.
Yihua Gao and Yoshio Bando
doi:10.1038/415599a
First paragraph | Full Text | PDF (75K)
Psychobiology: Speech sounds learned by sleeping newborns p599
M. Cheour, O. Martynova, R. Näätänen, R. Erkkola, M. Sillanpää, P. Kero, A. Raz, M.-L. Kaipio, J. Hiltunen, O. Aaltonen, J. Savela and H. Hämäläinen
doi:10.1038/415599b
First paragraph | Full Text | PDF (75K)
Microstructures: Spin-engineering magnetic media p600
S. P. Li, W. S. Lew, J. A. C. Bland, L. Lopez-Diaz, M. Natali, C. A. F. Vaz and Y. Chen
doi:10.1038/415600a
First paragraph | Full Text | PDF (216K)
Ecology (Communication arising): Is coral bleaching really adaptive? p601
Ove Hoegh-Guldberg, Ross J. Jones, Selina Ward and William K. Loh
doi:10.1038/415601a
First paragraph | Full Text | PDF (210K)
Ecology (Communication arising): Is coral bleaching really adaptive? p602
Andrew C. Baker
doi:10.1038/415602a
First paragraph | Full Text | PDF (41K)
erratum: Seeing through the face of deception p602
doi:10.1038/415602b
erratum: Laterality in tool manufacture by crows p602
doi:10.1038/415602c
Articles
Slowdown of the meridional overturning circulation in the upper Pacific Ocean p603
Michael J. McPhaden and Dongxiao Zhang
doi:10.1038/415603a
Abstract | Full Text | PDF (320K)
See also: News and Views by Langenberg
Visual predators select for crypticity and polymorphism in virtual prey p609
Alan B. Bond and Alan C. Kamil
doi:10.1038/415609a
Abstract | Full Text | PDF (370K)
Letters to Nature
Testing the thermodynamic approach to granular matter with a numerical model of a decisive experiment p614
Hernán A. Makse and Jorge Kurchan
doi:10.1038/415614a
First paragraph | Full Text | PDF (165K)
See also: News and Views by Behringer
Growth of nanowire superlattice structures for nanoscale photonics and electronics p617
Mark S. Gudiksen, Lincoln J. Lauhon, Jianfang Wang, David C. Smith and Charles M. Lieber
doi:10.1038/415617a
First paragraph | Full Text | PDF (288K)
Ultralow-threshold Raman laser using a spherical dielectric microcavity p621
S. M. Spillane, T. J. Kippenberg and K. J. Vahala
doi:10.1038/415621a
First paragraph | Full Text | PDF (133K)
Observation of ligand effects during alkene hydrogenation catalysed by supported metal clusters p623
A. M. Argo, J. F. Odzak, F. S. Lai and B. C. Gates
doi:10.1038/415623a
First paragraph | Full Text | PDF (149K) | Supplementary information
Towards robust regional estimates of CO2 sources and sinks using atmospheric transport models p626
Kevin Robert Gurney, Rachel M. Law, A. Scott Denning, Peter J. Rayner, David Baker, Philippe Bousquet, Lori Bruhwiler, Yu-Han Chen, Philippe Ciais, Songmiao Fan, Inez Y. Fung, Manuel Gloor, Martin Heimann, Kaz Higuchi, Jasmin John, Takashi Maki, Shamil Maksyutov, Ken Masarie, Philippe Peylin, Michael Prather, Bernard C. Pak, James Randerson, Jorge Sarmiento, Shoichi Taguchi, Taro Takahashi and Chiu-Wai Yuen
doi:10.1038/415626a
First paragraph | Full Text | PDF (215K) | Supplementary information
Unsuspected diversity among marine aerobic anoxygenic phototrophs p630
Oded Béjà, Marcelino T. Suzuki, John F. Heidelberg, William C. Nelson, Christina M. Preston, Tohru Hamada, Jonathan A. Eisen, Claire M. Fraser and Edward F. DeLong
doi:10.1038/415630a
First paragraph | Full Text | PDF (164K)
See also: News and Views by Karl
Sex differences in emigration and mortality affect optimal management of deer populations p633
T. H. Clutton-Brock, T. N. Coulson, E. J. Milner-Gulland, D. Thomson and H. M. Armstrong
doi:10.1038/415633a
First paragraph | Full Text | PDF (275K)
Influence of scene statistics on colour constancy p637
Jürgen Golz and Donald I. A. MacLeod
doi:10.1038/415637a
First paragraph | Full Text | PDF (184K)
Early consolidation in human primary motor cortex p640
Wolf Muellbacher, Ulf Ziemann, Joerg Wissel, Nguyet Dang, Markus Kofler, Stefano Facchini, Babak Boroojerdi, Werner Poewe and Mark Hallett
doi:10.1038/nature712
First paragraph | Full Text | PDF (139K)
Genome shuffling leads to rapid phenotypic improvement in bacteria p644
Ying-Xin Zhang, Kim Perry, Victor A. Vinci, Keith Powell, Willem P. C. Stemmer and Stephen B. del Cardayré
doi:10.1038/415644a
First paragraph | Full Text | PDF (123K) | Supplementary information
Vesicular restriction of synaptobrevin suggests a role for calcium in membrane fusion p646
Kuang Hu, Joe Carroll, Sergei Fedorovich, Colin Rickman, Andrei Sukhodub and Bazbek Davletov
doi:10.1038/415646a
First paragraph | Full Text | PDF (198K)
S-Cdk-dependent phosphorylation of Sld2 essential for chromosomal DNA replication in budding yeast p651
Hiroshi Masumoto, Sachiko Muramatsu, Yoichiro Kamimura and Hiroyuki Araki
doi:10.1038/nature713
First paragraph | Full Text | PDF (329K) | Supplementary information
An exonucleolytic activity of human apurinic/apyrimidinic endonuclease on 3' mispaired DNA p655
Kai-Ming Chou and Yung-Chi Cheng
doi:10.1038/415655a
First paragraph | Full Text | PDF (543K) | Supplementary information
See also: News and Views by Jiricny
Mechanism of force generation by myosin heads in skeletal muscle p659
Gabriella Piazzesi, Massimo Reconditi, Marco Linari, Leonardo Lucii, Yin-Biao Sun, Theyencheri Narayanan, Peter Boesecke, Vincenzo Lombardi and Malcolm Irving
doi:10.1038/415659a
First paragraph | Full Text | PDF (260K)
RanGAP mediates GTP hydrolysis without an arginine finger p662
Michael J. Seewald, Carolin Körner, Alfred Wittinghofer and Ingrid R. Vetter
doi:10.1038/415662a
First paragraph | Full Text | PDF (551K) | Supplementary information
erratum: Formation of coastline features by large-scale instabilities induced by high-angle waves p666
Andrew Ashton, A. Brad Murray and Olivier Arnoult
doi:10.1038/415666a
New on the Market
Sharpen up your image p667
Featuring image analysis, capture and sharing.
doi:10.1038/415667a
insight
forewordmalaria p669
doi:10.1038/415669a
introduction
Malaria in 2002 p670
Brian Greenwood and Theonest Mutabingwa
doi:10.1038/415670a
Abstract | Full Text | PDF (125K)
review article
The pathogenic basis of malaria p673
Louis H. Miller, Dror I. Baruch, Kevin Marsh and Ogobara K. Doumbo
doi:10.1038/415673a
Abstract | Full Text | PDF (571K)
The economic and social burden of malaria p680
Jeffrey Sachs and Pia Malaney
doi:10.1038/415680a
Abstract | Full Text | PDF (215K)
Medical need, scientific opportunity and the drive for antimalarial drugs p686
Robert G. Ridley
doi:10.1038/415686a
Abstract | Full Text | PDF (389K)
Progress and challenges for malaria vaccines p694
Thomas L. Richie and Allan Saul
doi:10.1038/415694a
Abstract | Full Text | PDF (334K)
Plasmodium, human and Anopheles genomics and malaria p702
Stephen L. Hoffman, G. Mani Subramanian, Frank H. Collins and J. Craig Venter
doi:10.1038/415702a
Abstract | Full Text | PDF (204K)
Satellite imagery in the study and forecast of malaria p710
David J. Rogers, Sarah E. Randolph, Robert W. Snow and Simon I. Hay
doi:10.1038/415710a
Abstract | Full Text | PDF (276K)
corporate support
The Medicines for Malaria Venture p715
Discovering developing and delivering new and affordable medicines for this deadly disease
Christopher C. Hentschel, PhD
doi:10.1038/415715a
GlaxoSmithKline & malaria p716
doi:10.1038/415716a