Naturejobs

Battling the brain drain p3

Paul Smaglik

doi:10.1038/nj6871-03a

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Space medicine, Chemistry, Pharmaceuticals and Transitions p99

doi:10.1038/nj6871-99a

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Opinion

Summits that matter p457

The European Commission has made good progress in gathering support for its new programme of basic and applied research. Now Europe's industries and heads of state need to fulfil promises made two years ago.

doi:10.1038/415457a

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News

Bush's budget boost puts NIH on target for doubled figures p459

Erika Check

doi:10.1038/415459a

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Physicists head for collision course p459

Geoff Brumfiel

doi:10.1038/415459b

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Minister set to reform Australia's universities p460

Peter Pockley

doi:10.1038/415460a

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Undersea plan leaves wrecks to rest in peace p460

Quirin Schiermeier

doi:10.1038/415460b

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Venter's departure sees Celera seek therapies p461

Carina Dennis

doi:10.1038/415461a

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Senators square up over cloning p461

Erika Check

doi:10.1038/415461b

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Nerve inflammation halts trial for Alzheimer's drug p462

Erika Check

doi:10.1038/415462a

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Progress in human genetics hindered by reluctance to share p462

David Adam

doi:10.1038/415462b

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Survey overlap impedes fossil hunters' study p463

Rex Dalton

doi:10.1038/415463a

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Delegates nudge fusion project closer to reality p463

David Cyranoski

doi:10.1038/415463b

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news in brief p464

doi:10.1038/415464a

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news feature

The rise of the bean counters p466

The Office of Management and Budget always exerts a powerful influence over the US government. But it is now taking a higher profile, and a stronger interest in science. Should researchers be alarmed? Colin Macilwain reports.

Colin Macilwain

doi:10.1038/415466a

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Inspired by immunity p468

By developing programs that mimic some of the functions of the immune system, computer scientists are tackling problems from fighting fraud to controlling robots. Erica Klarreich investigates.

Erica Klarreich

doi:10.1038/415468a

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Correspondence

False samples are not the same as blind controls p471

Informal efforts to "test" a laboratory corrupt the data stream, where integrity is crucial.

L. Scott Mills

doi:10.1038/415471a

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Mislabelling muddies the forest-survey waters p471

Steven W. Buskirk

doi:10.1038/415471b

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Regional network raises profile of local journals p471

Wladimir J. Alonso and Esteban Fernández-Juricic

doi:10.1038/415471c

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Laboratories' gravy train has ground to a halt p472

Luciano Maiani

doi:10.1038/415472a

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Tax-free pay lets funders evade responsibilities p472

Francis Barr

doi:10.1038/415472b

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People, payments and positions at DESY p472

Petra Folkerts

doi:10.1038/415472c

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Commentary

Mad hatters at the DNA tea party p473

A unique discovery brings fresh insight to the discovery of DNA's structure.

doi:10.1038/415473a

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Book Reviews

A certain chemistry p475

Neurologist Oliver Sacks recounts a childhood love affair.

John Emsley reviews Uncle Tungsten: Memories of a Chemical Boyhood by Oliver Sacks

doi:10.1038/415475a

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A heated fight against devastation p476

Daniel Nepstad reviews Forest Fires: Behavior and Ecological Effects edited by Edward A. Johnson and Kiyoko Miyanishi

doi:10.1038/415476a

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Every second counts p476

Ken Johnston reviews The Measurement of Time: Time, Frequency and the Atomic Clock by Claude Audoin, Bernard Guinot and Stephen Lyle

doi:10.1038/415476b

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Clock-watching through the ages p477

doi:10.1038/415477a

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When politics colours disease p477

Ken Fox reviews Dying in the City of the Blues: Sickle Cell Anemia and the Politics of Race and Health by Keith Wailoo

doi:10.1038/415477b

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Science in culture p478

Jonathan Knight reviews

doi:10.1038/415478a

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words

Fact and fantasy p479

The zoology created by our imagination is far outstripped by that of reality.

Sandra Knapp

doi:10.1038/415479a

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concepts

Balance: Mind-grasping gravity p481

Victor Smetacek

doi:10.1038/415481a

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News and Views

Climate science: The investment forecast p483

New studies predict that the risk of extreme rainfall over Europe and Asian monsoon regions is increasing, with more floods likely worldwide. Such long-range forecasting is pushing at the limit of current climate models.

Reiner Schnur

doi:10.1038/415483a

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Cancer: The molecular outlook p484

Many breast-cancer patients receive unnecessary treatment for possible tumour spread after the removal of a primary tumour. Molecular profiling should offer more accurate predictions of who needs such treatment.

Carlos Caldas and Samuel A. J. Aparicio

doi:10.1038/415484a

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Chemistry: One generation at a time p487

Controlled binding of atoms or molecules within a larger structure could offer new routes to drug delivery or nanoscale materials. Synthetic dendrimers can be tailored to bind ions in just such a regulated manner.

Christopher Gorman

doi:10.1038/415487a

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100 and 50 years ago p488

doi:10.1038/415488a

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Bacterial behaviour: Function by serendipity p488

Crystallography has provided an unusual route to the characterization of a bacterial signalling agent: the molecule concerned has been accidentally caught in the clutches of its receptor.

Dagmar Ringe

doi:10.1038/415488b

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Biogeography: Big thinking p489

Since the demise of the dinosaurs, no land vertebrate has matched them for size. Why? The answer may lie in the particular conditions prevailing in the Cretaceous period.

Brian A. Maurer

doi:10.1038/415489a

Full Text | PDF (121K)

Daedalus: The analysis of fug p491

David Jones

doi:10.1038/415491a

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Obituary: Don Craig Wiley (1944–2001) p492

Hidde L. Ploegh

doi:10.1038/415492a

Full Text | PDF (70K)

Brief Communications

Anatomy:  Photoreceptive net in the mammalian retina p493

This mesh of cells may explain how some blind mice can still tell day from night.

Ignacio Provencio, Mark D. Rollag and Ana Maria Castrucci

doi:10.1038/415493a

First paragraph | Full Text | PDF (290K)

Satellite imaging: Massive emissions of toxic gas in the Atlantic p493

Scarla J. Weeks, Bronwen Currie and Andrew Bakun

doi:10.1038/415493b

First paragraph | Full Text | PDF (290K)

Biomechanics: Dinosaur locomotion from a new trackway p494

Julia J. Day, David B. Norman, Paul Upchurch and H. Philip Powell

doi:10.1038/415494a

First paragraph | Full Text | PDF (265K)

Fish physiology: Dogfish hair cells sense hydrostatic pressure p495

Peter J. Fraser and Richard L. Shelmerdine

doi:10.1038/415495a

First paragraph | Full Text | PDF (111K)

Plankton blooms: Lysogeny in marine Synechococcus p496

L. McDaniel, L. A. Houchin, S. J. Williamson and J. H. Paul

doi:10.1038/415496a

First paragraph | Full Text | PDF (96K)

Article

Genome sequence of the plant pathogen Ralstonia solanacearum p497

M. Salanoubat, S. Genin, F. Artiguenave, J. Gouzy, S. Mangenot, M. Arlat, A. Billault, P. Brottier, J. C. Camus, L. Cattolico, M. Chandler, N. Choisne, C. Claudel-Renard, S. Cunnac, N. Demange, C. Gaspin, M. Lavie, A. Moisan, C. Robert, W. Saurin, T. Schiex, P. Siguier, P. Thébault, M. Whalen, P. Wincker, M. Levy, J. Weissenbach and C. A. Boucher

doi:10.1038/415497a

Abstract | Full Text | PDF (239K) | Supplementary information

Letters to Nature

Topologically protected quantum bits using Josephson junction arrays p503

L. B. Ioffe, M. V. Feigel'man, A. Ioselevich, D. Ivanov, M. Troyer and G. Blatter

doi:10.1038/415503a

First paragraph | Full Text | PDF (181K)

Real-space imaging of an orbital Kondo resonance on the Cr(001) surface p507

O. Yu. Kolesnychenko, R. de Kort, M. I. Katsnelson, A. I. Lichtenstein and H. van Kempen

doi:10.1038/415507a

First paragraph | Full Text | PDF (363K)

Stepwise radial complexation of imine groups in phenylazomethine dendrimers p509

Kimihisa Yamamoto, Masayoshi Higuchi, Satoshi Shiki, Masanori Tsuruta and Hiroshi Chiba

doi:10.1038/415509a

First paragraph | Full Text | PDF (263K) | Supplementary information

See also: News and Views by Gorman

Quantifying the risk of extreme seasonal precipitation events in a changing climate p512

T. N. Palmer and J. Räisänen

doi:10.1038/415512a

First paragraph | Full Text | PDF (202K)

See also: News and Views by Schnur

Increasing risk of great floods in a changing climate p514

P. C. D. Milly, R. T. Wetherald, K. A. Dunne and T. L. Delworth

doi:10.1038/415514a

First paragraph | Full Text | PDF (242K)

See also: News and Views by Schnur

Antarctic climate cooling and terrestrial ecosystem response p517

Peter T. Doran, John C. Priscu, W. Berry Lyons, John E. Walsh, Andrew G. Fountain, Diane M. McKnight, Daryl L. Moorhead, Ross A. Virginia, Diana H. Wall, Gary D. Clow, Christian H. Fritsen, Christopher P. McKay and Andrew N. Parsons

doi:10.1038/nature710

First paragraph | Full Text | PDF (196K)

DNA reveals high dispersal synchronizing the population dynamics of Canada lynx p520

Michael K. Schwartz, L. Scott Mills, Kevin S. McKelvey, Leonard F. Ruggiero and Fred W. Allendorf

doi:10.1038/415520a

First paragraph | Full Text | PDF (193K)

Identification of diploid endosperm in an early angiosperm lineage p522

Joseph H. Williams and William E. Friedman

doi:10.1038/415522a

First paragraph | Full Text | PDF (226K) | Supplementary information

Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1 p526

Rui M. Costa, Nikolai B. Federov, Jeff H. Kogan, Geoffrey G. Murphy, Joel Stern, Masuo Ohno, Raju Kucherlapati, Tyler Jacks and Alcino J. Silva

doi:10.1038/nature711

First paragraph | Full Text | PDF (343K)

Gene expression profiling predicts clinical outcome of breast cancer p530

Laura J. van 't Veer, Hongyue Dai, Marc J. van de Vijver, Yudong D. He, Augustinus A. M. Hart, Mao Mao, Hans L. Peterse, Karin van der Kooy, Matthew J. Marton, Anke T. Witteveen, George J. Schreiber, Ron M. Kerkhoven, Chris Roberts, Peter S. Linsley, René Bernards and Stephen H. Friend

doi:10.1038/415530a

First paragraph | Full Text | PDF (883K) | Supplementary information

See also: News and Views by Caldas & Aparicio

Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease p536

Laurent Monney, Catherine A. Sabatos, Jason L. Gaglia, Akemi Ryu, Hanspeter Waldner, Tatyana Chernova, Stephen Manning, Edward A. Greenfield, Anthony J. Coyle, Raymond A. Sobel, Gordon J. Freeman and Vijay K. Kuchroo

doi:10.1038/415536a

First paragraph | Full Text | PDF (430K)

Phospholipase C1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE p541

Keqiang Ye, Bahman Aghdasi, Hongbo R. Luo, John L. Moriarity, Frederick Y. Wu, Jenny J. Hong, K. Joseph Hurt, Sun Sik Bae, Pann-Ghill Suh and Solomon H. Snyder

doi:10.1038/415541a

First paragraph | Full Text | PDF (164K) | Supplementary information

Structural identification of a bacterial quorum-sensing signal containing boron p545

Xin Chen, Stephan Schauder, Noelle Potier, Alain Van Dorsselaer, István Pelczer, Bonnie L. Bassler and Frederick M. Hughson

doi:10.1038/415545a

First paragraph | Full Text | PDF (326K)

See also: News and Views by Ringe

Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators p549

Stephen J. Demarest, Maria Martinez-Yamout, John Chung, Hongwu Chen, Wei Xu, H. Jane Dyson, Ronald M. Evans and Peter E. Wright

doi:10.1038/415549a

First paragraph | Full Text | PDF (540K) | Supplementary information

Structure of the cell-puncturing device of bacteriophage T4 p553

Shuji Kanamaru, Petr G. Leiman, Victor A. Kostyuchenko, Paul R. Chipman, Vadim V. Mesyanzhinov, Fumio Arisaka and Michael G. Rossmann

doi:10.1038/415553a

First paragraph | Full Text | PDF (453K)

New on the Market

Technological trends p559

Products with a biotech bias, including a separator good for over 100 l.p.h.

doi:10.1038/415559a

Full Text | PDF (149K)