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Nature 415, 272-273 (17 January 2002) | doi:10.1038/415272b

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AIDS vaccines: One step forwards, one step back

Jeffrey D. Lifson1 & Malcolm A. Martin2

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New AIDS-virus vaccines induce cellular responses that can contain, but not prevent, infection. Mutations can allow the virus to escape this immune control, emphasizing the challenges in developing an effective vaccine.

As someone accustomed to persevering on a long-term project in which repeated periods of hard work lead to modest progress, only to be followed by setbacks, Sisyphus would be well suited to a career in AIDS-vaccine research. Papers on pages 331 and 335 of this issue1, 2 illustrate the point.

  1. Jeffrey D. Lifson is in the AIDS Vaccine Program, SAIC Frederick, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA.
    e-mail: Email: lifson@avpaxp1.ncifcrf.gov
  2. Malcolm A. Martin is in the Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA.
    e-mail: Email: mmartin@niaid.nih.gov