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News and Views
Nature 415, 272-273 (17 January 2002) | doi:10.1038/415272b
AIDS vaccines: One step forwards, one step back
Jeffrey D. Lifson1 & Malcolm A. Martin2
Abstract
New AIDS-virus vaccines induce cellular responses that can contain, but not prevent, infection. Mutations can allow the virus to escape this immune control, emphasizing the challenges in developing an effective vaccine.
As someone accustomed to persevering on a long-term project in which repeated periods of hard work lead to modest progress, only to be followed by setbacks, Sisyphus would be well suited to a career in AIDS-vaccine research. Papers on pages 331 and 335 of this issue1, 2 illustrate the point.
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