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Nature 415, 8-9 (3 January 2002) | doi:10.1038/415008a

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Surviving a knockout blow

Helen Pearson1

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Disabling a gene in one mouse strain can be fatal — but in another strain it can produce animals that seem normal. Making sense of such results requires stamina and skill, says Helen Pearson.

Some mice should, by rights, be dead. At the very least, Teyumuras Kurzchalia expected his to be critically ill.