FIGURE 2. Balancing cancer and ageing.
From the following article:
Ageing: The price of tumour suppression?
Gerardo Ferbeyre and Scott W. Lowe
Nature 415, 26-27(3 January 2002)
doi:10.1038/415026a
a, Increases in p53 activity reduce the incidence of cancer but increase the ageing rate. Conversely, decreases in p53 activity increase cancer incidence but may decrease the rate of ageing. b, As a consequence, the influence of p53 on lifespan may result from a delicate balance between its antitumour and pro-ageing effects, such that too little p53 increases mortality from cancer whereas too much p53 increases mortality from ageing.
