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Nature 414, 813-820 (13 December 2001) | doi:10.1038/414813a
Open Innovation Challenges
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Fast Growth of Transformed Soybean Shoots
A method for accelerating growth of soybean shoots is desired.
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Protect Enzyme from In Planta Degradation
A proposal for stable expression of an enzyme in corn seed is desired.
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Principal Scientist - Pain in Vitro Cell Biologist
- GlaxoSmithKline
- Harlow, Essex United Kingdom
Post-Doctoral Position BAT IIa
- Justus-Liebig-University Giessen
- Giessen 35390 Germany
review article Biochemistry and molecular cell biology of diabetic complications
Michael Brownlee
Abstract
Diabetes-specific microvascular disease is a leading cause of blindness, renal failure and nerve damage, and diabetes-accelerated atherosclerosis leads to increased risk of myocardial infarction, stroke and limb amputation. Four main molecular mechanisms have been implicated in glucose-mediated vascular damage. All seem to reflect a single hyperglycaemia-induced process of overproduction of superoxide by the mitochondrial electron-transport chain. This integrating paradigm provides a new conceptual framework for future research and drug discovery.
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