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Nature 414, 701-703 (13 December 2001) | doi:10.1038/414701a
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Immunology: Bug detectors
Tsuneyasu Kaisho1 & Shizuo Akira1
Abstract
Insects and mammals are thought to have similar 'innate' immune responses to infectious microorganisms. But there are differences, and even more now emerge from studies of how insects detect bacteria.
To respond rapidly to invading microorganisms, animals call on their innate immune systems. These consist of microbe-detecting molecules, which are connected to cascades of signalling proteins that in turn activate immune cells.
- Tsuneyasu Kaisho and Shizuo Akira are in the Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, and SORST, Japan Science and Technology Corporation, Japan.
Correspondence to: Shizuo Akira1 e-mail: Email: sakira@biken.osaka-u.ac.jp
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