Figures and Tables

From the following article:

Biochemistry and molecular cell biology of diabetic complications

Michael Brownlee

Nature 414, 813-820(13 December 2001)

doi:10.1038/414813a

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Figure 1

Aldose reductase and the polyol pathway.

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Figure 2

Mechanisms by which intracellular production of advanced glycation end-product (AGE) precursors damages vascular cells.

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Figure 3

Consequences of hyperglycaemia-induced activation of protein kinase C (PKC).

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Figure 4

The hexosamine pathway.

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Figure 5

Production of superoxide by the mitochondrial electron-transport chain.

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Figure 6

Potential mechanism by which hyperglycaemia-induced mitochondrial superoxide overproduction activates four pathways of hyperglycaemic damage.

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