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Nature 414, 593-595 (6 December 2001) | doi:10.1038/414593a
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Cell biology: Conservation signals location
Alexandre Costa1 & Paul Schedl1
Abstract
During development, many messenger RNAs are spread asymmetrically within cells. Surprisingly, in fruitflies the RNA signals and machinery used for distribution seem to be conserved in different developmental stages.
The asymmetric localization of messenger RNA molecules (mRNAs) is used in cells as diverse as eggs and neurons to restrict the expression and spatial distribution of proteins. mRNA localization depends both on special signals in the mRNAs themselves ('cis-acting' signals) and on the RNA-binding proteins that recognize these signals ('trans-acting' factors).
- Alexandre Costa and Paul Schedl are in the Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA.
Correspondence to: Paul Schedl1 e-mail: Email: pschedl@molbio.princeton.edu
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