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Nature 414, 163-164 (8 November 2001) | doi:10.1038/35102664

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Developmental biology: Gridlock in the blood

Gavin Thurston1 & George D. Yancopoulos1

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All blood vessels originate from the same precursor cells in early embryos. So how do those precursors decide whether to contribute to arteries or veins? Studies of zebrafish bring us closer to the answer.

How do developing embryos grow a complex network of blood vessels with the correct proportions of arteries, veins and capillaries? On page 216 of this issue Zhong and colleagues1 describe the crucial role of a gene called gridlock, which influences the earliest decisions that the precursors of blood vessels must make.

  1. Gavin Thurston and George D. Yancopoulos are at Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591, USA.

Correspondence to: Gavin Thurston1 e-mail: Email: gavin.thurston@regeneron.com

Correspondence to: George D. Yancopoulos1 e-mail: Email: george@regeneron.com