FIGURE 2. Sequence alignment of ATR with the I domain of integrin 2 (2-I), the von Willebrand factor A domain consensus sequence (VWA-CON, generated from 210 sequences aligned by the National Center for Biotechnology Information), and TEM8.

The secondary structural elements are based on the crystal structure of the 2-I domain³⁰. Conserved amino acids are boxed and identical amino acids are indicated by shaded boxes. The putative signal sequence is underlined. The five residues that form the MIDAS motif are indicated with asterisks. The putative transmembrane domains of ATR and TEM8 are indicated by a shaded box. Potential N-linked glycosylation sites in ATR and TEM8 are indicated by hatched boxes. The alignment was made with the programs ClustalW and ESPript 1.9 (the Risler matrix was used with a global score of 0.7).