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Nature 413, 695-696 (18 October 2001) | doi:10.1038/35099665
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Molecular biology: RNA enzymes for RNA splicing
Andy Newman
Abstract
Many messenger RNAs are not functional until they are processed by a complex called the spliceosome. It seems increasingly likely that processing is catalysed by the RNA — and not the protein — parts of this complex.
The discovery of catalytic RNAs in 1982 forced proteins to relinquish their status as the only molecules that can catalyse chemical reactions in living cells. For instance, RNA forms the active site in the ribosome, the complex molecular machine that catalyses protein synthesis.
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