Table of contents
Volume 413 Number 6855 pp3-550
Naturejobs
prospectsShaking off genome fatigue p3
Paul Smaglik
doi:10.1038/35097201
Special Report
Population Genetics p4
Population geneticists are in short supply, as the need to translate large data sets into disease-susceptibility traits grows, says Eugene Russo
Eugene Russo
doi:10.1038/35097203
Opinion
Industrial 'R' up in a downturn p439
In markets that have never been tougher, IT and telecoms companies are well structured for essential innovation. Investors are recognizing this, but some governments risk losing long-term opportunities by failing to invest in related research.
doi:10.1038/35097214
News
Large Hadron Collider in crisis as magnet costs spiral upwards p441
David Adam
doi:10.1038/35097216
Senators call for biodefence boost p441
Jonathan Knight
doi:10.1038/35097219
Bilateral Vietnam study plans to assess war fallout of dioxin p442
Rex Dalton
doi:10.1038/35097221
Eviction threat to Belgium's science academies p442
Quirin Schiermeier
doi:10.1038/35097224
Doctors propose panel on research misconduct p442
Erica Klarreich
doi:10.1038/35097226
Testing time for gene patent as Europe rebels p443
Meredith Wadman
doi:10.1038/35097228
Last-minute floods sink research p443
Alison Abbott
doi:10.1038/35097231
Mouse genome roars ahead with new map p444
Declan Butler
doi:10.1038/35097234
Psychiatrist launches lawsuit over 'academic freedom' p444
David Spurgeon
doi:10.1038/35097237
NASA budget problems alarm space-station collaborators p445
William Triplett
doi:10.1038/35097240
Vatican approves use of animal transplants 'to benefit humans' p445
Xavier Bosch
doi:10.1038/35097243
news feature
Hard times for high tech p448
Computer and telecoms firms are losing money and laying off staff — yet say that R&D remains a priority. Can their scientists really remain immune to the economic downturn? Declan Butler and Jim Giles investigate.
Declan Butler and Jim Giles
doi:10.1038/35097252
Biologists join the dots p450
Tiny specks of semiconductor can make biological molecules and cellular components glow in a kaleidoscope of colours. These 'quantum dots' may soon be a standard biological tool, says Erica Klarreich.
Erica Klarreich
doi:10.1038/35097256
Correspondence
Rules on originality need to be clearly set out p453
Tadasu Nagaoka and Hisatsugu Miyakoshi
doi:10.1038/35097263
Related problems p453
Alex C. W. May
doi:10.1038/35097265
Give us time to put reforms into action p453
Enrico Garaci
doi:10.1038/35097267
In the stem-cell debate, new concepts need new words p453
Confusion arises when the existing vocabulary we use is inadequate to describe new methodologies.
Ann A. Kiessling
doi:10.1038/35097269
Book Reviews
Whither evo–devo? p455
Assessing the interplay between evolutionary and developmental processes.
Axel Meyer reviews From DNA to Diversity: Molecular Genetics and the Evolution of Animal Design by Sean B. Carroll, Jennifer K. Grenier and Scott D. Weatherbee
doi:10.1038/35097131
The shrinking world of corals p456
doi:10.1038/35097134
No easy answers p457
Xavier Bosch reviews Human Trials: Scientists, Investors, and Patients in the Quest for a Cure by Susan Quinn
doi:10.1038/35097137
Is content king? p458
Johanna McEntyre reviews The Encyclopedia of Life Sciences (http://www.els.net)
doi:10.1038/35097140
Poking around among the mammals p459
doi:10.1038/35097144
A new window on space p459
Ingo Lehmann reviews Revealing the Universe: The Making of the Chandra X-ray Observatory by Wallace Tucker and Karen Tucker
doi:10.1038/35097147
Science in culture p460
Martin Kemp reviews
doi:10.1038/35097149
words
Tales behind the tags p461
Physics is crowded with evocative phrases, but these alone cannot show the whole picture.
Philip Morrison
doi:10.1038/35097170
News and Views
Talk of genetics and vice versa p465
Does our ability to talk lie in our genes? The suspicion is bolstered by the discovery of a gene that might affect how the brain circuitry needed for speech and language develops.
Steven Pinker
doi:10.1038/35097173
Bose–Einstein condensates: Mastering the language of atoms p466
Physicists can already make ultracold atoms perform quantum tricks in sophisticated magnetic and optical traps. But a fast route to trapping atoms on a microchip opens up new possibilities.
Ron Folman and Jörg Schmiedmayer
doi:10.1038/35097176
Bacterial genomics: A plague o' both your hosts p467
The genome of the bacterium that causes plague is highly dynamic, and scarred by genes acquired from other organisms. Does this explain its ability to kill both mammals and insects?
Stewart T. Cole and Carmen Buchrieser
doi:10.1038/35097178
100 and 50 years ago p469
doi:10.1038/35097181
Global change: Chill taken out of the tropics p470
A paradox in palaeoclimatology has been the apparent existence of a cool sea surface in the tropics under conditions of high CO2 in the atmosphere. It looks as if that paradox has been resolved.
Lee R. Kump
doi:10.1038/35097183
Neurobiology: Developing order p471
Different types of nerve cells are made in a particular sequence during development. But how? Studies of fruitflies reveal a temporal order in the expression of the genes that regulate these decisions.
Rick Livesey and Connie Cepko
doi:10.1038/35097186
Gravitational physics: Black hole blockbuster p473
Sarah Tomlin
doi:10.1038/35097189
Acoustic physics: Suspended by sound p474
Ultrasound waves can levitate heavy balls of tungsten. This contact-free method of keeping items suspended in the air can be applied to the investigation and processing of new materials.
E. H. Brandt
doi:10.1038/35097192
Human genetics: To clot or not p475
In multicellular animals, there has to be a balance between the free flow and clotting of blood. One molecule involved is von Willebrand factor, and the enzyme that cuts it down to size is now unveiled.
Amanda J. Fosang and Peter J. Smith
doi:10.1038/35097196
Daedalus: Learning from melting p476
David Jones
doi:10.1038/35097199
Brief Communications
Snapping shrimp make flashing bubbles p477
The cavitation bubbles created by shrimp in stunning their prey have some surprising properties.
Detlef Lohse, Barbara Schmitz and Michel Versluis
doi:10.1038/35097152
First paragraph | Full Text | PDF (127K)
Carbon emissions: The economic benefits of the Kyoto Protocol p478
Giulio A. De Leo, Luca Rizzi, Andrea Caizzi and Marino Gatto
doi:10.1038/35097156
First paragraph | Full Text | PDF (116K) | Supplementary information
Palaeolithic paintings: Evolution of prehistoric cave art p479
H. Valladas, J. Clottes, J.-M. Geneste, M. A. Garcia, M. Arnold, H. Cachier and N. Tisnérat-Laborde
doi:10.1038/35097160
First paragraph | Full Text | PDF (98K) | Supplementary information
Physiology: Cold current in thermoreceptive neurons p480
Gordon Reid and Maria-Luiza Flonta
doi:10.1038/35097164
First paragraph | Full Text | PDF (89K)
Articles
Warm tropical sea surface temperatures in the Late Cretaceous and Eocene epochs p481
Paul N. Pearson, Peter W. Ditchfield, Joyce Singano, Katherine G. Harcourt-Brown, Christopher J. Nicholas, Richard K. Olsson, Nicholas J. Shackleton and Mike A. Hall
doi:10.1038/35097000
Abstract | Full Text | PDF (380K) | Supplementary information
See also: News and Views by Kump
Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura p488
Gallia G. Levy, William C. Nichols, Eric C. Lian, Tatiana Foroud, Jeanette N. McClintick, Beth M. McGee, Angela Y. Yang, David R. Siemieniak, Kenneth R. Stark, Ralph Gruppo, Ravindra Sarode, Susan B. Shurin, Visalam Chandrasekaran, Sally P. Stabler, Hernan Sabio, Eric E. Bouhassira, Jefferson D. Upshaw, Jr, David Ginsburg and Han-Mou Tsai
doi:10.1038/35097008
Abstract | Full Text | PDF (304K) | Supplementary information
See also: News and Views by Fosang & Smith
Letters to Nature
Light interference from single atoms and their mirror images p495
J. Eschner, Ch. Raab, F. Schmidt-Kaler and R. Blatt
doi:10.1038/35097017
First paragraph | Full Text | PDF (181K)
Bose–Einstein condensation on a microelectronic chip p498
W. Hänsel, P. Hommelhoff, T. W. Hänsch and J. Reichel
doi:10.1038/35097032
First paragraph | Full Text | PDF (245K)
See also: News and Views by Folman & Schmiedmayer
Spatially resolved electronic structure inside and outside the vortex cores of a high-temperature superconductor p501
V. F. Mitrovi
,
E. E. Sigmund,
M. Eschrig,
H. N. Bachman,
W. P. Halperin,
A. P. Reyes,
P. Kuhns
and
W. G. Moulton
doi:10.1038/35097039
First paragraph | Full Text | PDF (194K)
Swollen liquid-crystalline lamellar phase based on extended solid-like sheets p504
Jean-Christophe P. Gabriel, Franck Camerel, Bruno J. Lemaire, Hervé Desvaux, Patrick Davidson and Patrick Batail
doi:10.1038/35097046
First paragraph | Full Text | PDF (303K) | Supplementary information
High frequency of 'super-cyclones' along the Great Barrier Reef over the past 5,000 years p508
Jonathan Nott and Matthew Hayne
doi:10.1038/35097055
First paragraph | Full Text | PDF (171K)
Multiple benefits of gregariousness cover detectability costs in aposematic aggregations p512
Marianna Riipi, Rauno V. Alatalo, Leena Lindström and Johanna Mappes
doi:10.1038/35097061
First paragraph | Full Text | PDF (130K)
Positive selection of a gene family during the emergence of humans and African apes p514
Matthew E. Johnson, Luigi Viggiano, Jeffrey A. Bailey, Munah Abdul-Rauf, Graham Goodwin, Mariano Rocchi and Evan E. Eichler
doi:10.1038/35097067
First paragraph | Full Text | PDF (224K) | Supplementary information
A forkhead-domain gene is mutated in a severe speech and language disorder p519
Cecilia S. L. Lai, Simon E. Fisher, Jane A. Hurst, Faraneh Vargha-Khadem and Anthony P. Monaco
doi:10.1038/35097076
First paragraph | Full Text | PDF (268K) | Supplementary information
See also: News and Views by Pinker
Genome sequence of Yersinia pestis, the causative agent of plague p523
J. Parkhill, B. W. Wren, N. R. Thomson, R. W. Titball, M. T. G. Holden, M. B. Prentice, M. Sebaihia, K. D. James, C. Churcher, K. L. Mungall, S. Baker, D. Basham, S. D. Bentley, K. Brooks, A. M. Cerdeño-Tárraga, T. Chillingworth, A. Cronin, R. M. Davies, P. Davis, G. Dougan, T. Feltwell, N. Hamlin, S. Holroyd, K. Jagels, A. V. Karlyshev, S. Leather, S. Moule, P. C. F. Oyston, M. Quail, K. Rutherford, M. Simmonds, J. Skelton, K. Stevens, S. Whitehead and B. G. Barrell
doi:10.1038/35097083
First paragraph | Full Text | PDF (438K) | Supplementary information
See also: News and Views by Cole & Buchrieser
An endogenous cannabinoid (2-AG) is neuroprotective after brain injury p527
David Panikashvili,
Constantina Simeonidou,
Shimon Ben-Shabat,
Lumír Hanu
,
Aviva Breuer,
Raphael Mechoulam
and
Esther Shohami
doi:10.1038/35097089
First paragraph | Full Text | PDF (199K)
A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing TH2 bias of natural killer T cells p531
Katsuichi Miyamoto, Sachiko Miyake and Takashi Yamamura
doi:10.1038/35097097
First paragraph | Full Text | PDF (182K)
Direct ligand–receptor complex interaction controls Brassica self-incompatibility p534
Seiji Takayama, Hiroko Shimosato, Hiroshi Shiba, Miyuki Funato, Fang-Sik Che, Masao Watanabe, Megumi Iwano and Akira Isogai
doi:10.1038/35097104
First paragraph | Full Text | PDF (433K)
Quality control of mRNA 3'-end processing is linked to the nuclear exosome p538
Patricia Hilleren, Terri McCarthy, Michael Rosbash, Roy Parker and Torben Heick Jensen
doi:10.1038/35097110
First paragraph | Full Text | PDF (380K) | Supplementary information
Transmission intensity and impact of control policies on the foot and mouth epidemic in Great Britain p542
Neil M. Ferguson, Christl A. Donnelly and Roy M. Anderson
doi:10.1038/35097116
First paragraph | Full Text | PDF (801K) | Supplementary information
erratum: The timing of the last deglaciation in North Atlantic climate records p548
Claire Waelbroeck, Jean-Claude Duplessy, Elisabeth Michel, Laurent Labeyrie, Didier Paillard and Josette Duprat
doi:10.1038/35097124
erratum: Control of conformational and interpolymer effects in conjugated polymers p548
J. Kim and M. Swager
doi:10.1038/35097126
erratum: Partitioning selection and complementarity in biodiversity experiments p548
Michel Loreau and Andy Hector
doi:10.1038/35097128
New on the Market
High-throughput screening p549
Assay kits, plates, probes and rotors for high throughput.
doi:10.1038/35097167
