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Nature 413, 125-126 (13 September 2001) | doi:10.1038/35093198
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Metabolism: Controlling the glucose factory
Antonio Vidal-Puig1 & Stephen O'Rahilly1
Abstract
In times of starvation the liver turns into a glucose-producing organ, providing fuel for the brain. The hormonal signals that control this switch in glucose metabolism may converge on a single regulatory molecule.
Mammals have evolved sophisticated systems to maintain glucose levels in the blood within tight limits, despite large fluctuations in food intake. The main drive for such strict control is the brain's near-absolute requirement for glucose as an energy source.
- Antonio Vidal-Puig and Stephen O'Rahilly are in the Departments of Medicine and Clinical Biochemistry, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK.
Correspondence to: Stephen O'Rahilly1 e-mail: Email: sorahill@hgmp.mrc.ac.uk
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