Table of contents
Volume 413 Number 6851 pp1-91
Opinion
The future of the electronic scientific literature p1
The Internet's transformation of scientific communication has only begun, but already much of its promise is within reach. The vision below may change in its detail, but experimentation and lack of dogmatism are undoubtedly the way forward.
doi:10.1038/35092665
Naturejobs
prospectsPresenting Naturejobs.com 2 p3
Paul Smaglik
doi:10.1038/35092703
careers and recruitment
Building protein pipelines p4
The industrial revolution that is reshaping structural biology is opening doors of opportunity for computer scientists and protein chemists alike, says Paul Smaglik.
Paul Smaglik
News
Fears for basic science as Bush backs use of investment criteria p5
Colin Macilwain
doi:10.1038/35092667
Stanford gift scaled back over federal stem-cell policy p5
Rex Dalton
doi:10.1038/35092670
Y-chromosome analysis urged for sex crimes p6
Quirin Schiermeier
doi:10.1038/35092672
Journal boycott presses demand for free access p6
Jonathan Knight
doi:10.1038/35092675
Environmental laws face military manoeuvres p7
Mark Schrope
doi:10.1038/35092677
Listing resumes for species at risk p7
Mark Schrope
doi:10.1038/35092681
Naturejobs
careers and recruitmentJapan in the post-genomics age p7
Over the past two years, the Japanese government has increased funding for research in structural genomics. Although companies remain uncertain as to how this will benefit them, there will be more job opportunities in protein engineering and structural biology, says Robert Triendl.
Robert Triendl
doi:10.1038/35092712
News
Japan plans revision of science lessons p8
David Cyranoski
doi:10.1038/35092683
Ministry attempts to breathe life into clinical trials p8
David Cyranoski
doi:10.1038/35092686
Liver tumours temper hopes for gene-therapy technique p9
Helen Pearson
doi:10.1038/35092689
Celera and Motorola brought in to aid hunt for disease genes p9
Jonathan Knight
doi:10.1038/35092692
news feature
Biology's last taboo p12
Will gene therapy ever extend to inducing changes in humans that can be inherited down through generations? Maybe so, if the concerns over safety can be ironed out. Jonathan Knight considers the technical challenges and the ethical arguments.
Jonathan Knight
doi:10.1038/35092627
Correspondence
Brazil has the talent: just let us get on with the job p16
Frustrated researchers are calling for support from the international scientific community.
Sérvio P. Ribeiro, Milton de S. Mendonça-Júnior, Edésio M. Barbosa and J. Adauto de Souza Neto
doi:10.1038/35092697
Group did give timely foot-and-mouth analysis p16
Roy M. Anderson, Neil M. Ferguson and Christl A. Donnelly
doi:10.1038/35092699
To boldly go where no plant has yet been found p16
Cindy Lee Van Dover
doi:10.1038/35092701
Book Reviews
The ultimate means of destruction p17
How the British hydrogen bomb was born.
Stuart Croft reviews Britain and the H-Bomb by Lorna Arnold
doi:10.1038/35092600
Fossilized art p18
doi:10.1038/35092604
Counting on the metaphorical p18
Gerald A. Goldin reviews Where Mathematics Comes From: How the Embodied Mind Brings Mathematics into Being by George Lakoff and Rafael E. Núñez
doi:10.1038/35092607
Sticking by our one and only? p19
T. R. Birkhead reviews The Myth of Monogamy: Fidelity and Infidelity in Animals and People by David P. Barash and Judith Eve Lipton
doi:10.1038/35092609
words
A tale from Bioutopia p21
Could a change of nomenclature bring peace to biology's warring tribes?
Pier Luigi Nimis
doi:10.1038/35092637
News and Views
X-rays from the edge of infinity p25
The supermassive black hole at the centre of our Galaxy has a strong influence on its surroundings. Astronomers cannot yet see this beast directly but they now have a much better idea of its size.
Fulvio Melia
doi:10.1038/35092644
Cardiovascular biology: Platelets and proteases p26
Circulating platelets are essential for the formation of blood clots. Studies of mice reveal more about the proteins involved in activating platelets, with implications for understanding strokes and heart attacks.
Skip Brass
doi:10.1038/35092647
Earth science: Core beliefs p27
Working out what happens in the extreme conditions at the centre of the Earth is not easy. A calculation of the properties of iron under such conditions helps to explain seismic observations of the inner core.
Andrew Jephcoat and Keith Refson
doi:10.1038/35092650
100 and 50 years ago p29
doi:10.1038/35092653
Cytoskeleton: Evolution in bacteria p30
Actin is a major component of the cytoskeleton in yeast, plant and animal cells, but when did it evolve? The discovery of a bacterial protein that forms actin-like filaments suggests an answer.
Harold P. Erickson
doi:10.1038/35092655
Supramolecular chemistry: Going for gold p31
Molecules containing gold atoms are not expected to form metallic bonds. But there is growing evidence that there are interactions between the gold atoms that are similar in strength to hydrogen bonds.
Hubert Schmidbaur
doi:10.1038/35092657
Archaeology: Out in the cold p33
Humans are very adaptable: during the last ice age, they apparently lived within the Arctic Circle. The discovery suggests that, although cold, the region was probably not covered in ice at the time.
John A. J. Gowlett
doi:10.1038/35092660
Daedalus: Pay for the Internet p34
David Jones
doi:10.1038/35092663
Brief Communications
Language rhythms in baby hand movements p35
Hearing babies born to deaf parents babble silently with their hands.
Laura Ann Petitto, Siobhan Holowka, Lauren E. Sergio and David Ostry
doi:10.1038/35092613
Spectrographic imaging: A bird's-eye view of the health of coral reefs p36
Peter J. Mumby, John R. M. Chisholm, Chris D. Clark, John D. Hedley and Jean Jaubert
doi:10.1038/35092617
First paragraph | Full Text | PDF (95K)
Immune recognition: A new receptor for 
-glucans p36
Gordon D. Brown and Siamon Gordon
doi:10.1038/35092620
First paragraph | Full Text | PDF (95K)
Evolutionary genetics: Clonal inheritance of avian mitochondrial DNA p37
Sofia Berlin and Hans Ellegren
doi:10.1038/35092623
First paragraph | Full Text | PDF (98K)
Article
Prokaryotic origin of the actin cytoskeleton p39
Fusinita van den Ent, Linda A. Amos and Jan Löwe
doi:10.1038/35092500
Abstract | Full Text | PDF (422K) | Supplementary information
See also: News and Views by Erickson
Letters to Nature
Rapid X-ray flaring from the direction of the supermassive black hole at the Galactic Centre p45
F. K. Baganoff, M. W. Bautz, W. N. Brandt, G. Chartas, E. D. Feigelson, G. P. Garmire, Y. Maeda, M. Morris, G. R. Ricker, L. K. Townsley and F. Walter
doi:10.1038/35092510
First paragraph | Full Text | PDF (215K)
See also: News and Views by Melia
How 'spin ice' freezes p48
J. Snyder, J. S. Slusky, R. J. Cava and P. Schiffer
doi:10.1038/35092516
First paragraph | Full Text | PDF (212K)
Fluidity of water confined to subnanometre films p51
Uri Raviv, Pierre Laurat and Jacob Klein
doi:10.1038/35092523
First paragraph | Full Text | PDF (188K)
Anomalous properties in ferroelectrics induced by atomic ordering p54
A. M. George, Jorge Íñiguez and L. Bellaiche
doi:10.1038/35092530
First paragraph | Full Text | PDF (220K)
Elasticity of iron at the temperature of the Earth's inner core p57
Gerd Steinle-Neumann, Lars Stixrude, R. E. Cohen and Oguz Gülseren
doi:10.1038/35092536
First paragraph | Full Text | PDF (172K)
See also: News and Views by Jephcoat & Refson
Texturing of the Earth's inner core by Maxwell stresses p60
B. A. Buffett and H.-R. Wenk
doi:10.1038/35092543
First paragraph | Full Text | PDF (229K)
See also: News and Views by Jephcoat & Refson
Human presence in the European Arctic nearly 40,000 years ago p64
Pavel Pavlov, John Inge Svendsen and Svein Indrelid
doi:10.1038/35092552
First paragraph | Full Text | PDF (404K)
See also: News and Views by Gowlett
A cellular mechanism of reward-related learning p67
John N. J. Reynolds, Brian I. Hyland and Jeffery R. Wickens
doi:10.1038/35092560
First paragraph | Full Text | PDF (392K)
Mobilization of a Drosophila transposon in the Caenorhabditis elegans germ line p70
Jean-Louis Bessereau, Ashley Wright, Daniel C. Williams, Kim Schuske, M. Wayne Davis and Erik M. Jorgensen
doi:10.1038/35092567
First paragraph | Full Text | PDF (212K)
Role of thrombin signalling in platelets in haemostasis and thrombosis p74
Gilberto R. Sambrano, Ethan J. Weiss, Yao-Wu Zheng, Wei Huang and Shaun R. Coughlin
doi:10.1038/35092573
First paragraph | Full Text | PDF (251K)
See also: News and Views by Brass
Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction p78
Katherine A. Fitzgerald, Eva M. Palsson-McDermott, Andrew G. Bowie, Caroline A. Jefferies, Ashley S. Mansell, Gareth Brady, Elizabeth Brint, Aisling Dunne, Pearl Gray, Mary T. Harte, Diane McMurray, Dirk E. Smith, John E. Sims, Timothy A. Bird and Luke A. J. O'Neill
doi:10.1038/35092578
First paragraph | Full Text | PDF (292K)
Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice p83
Paul Krimpenfort, Kim C. Quon, Wolter J. Mooi, Ate Loonstra and Anton Berns
doi:10.1038/35092584
First paragraph | Full Text | PDF (298K) | Supplementary information
Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis p86
Norman E. Sharpless, Nabeel Bardeesy, Kee-Ho Lee, Daniel Carrasco, Diego H. Castrillon, Andrew J. Aguirre, Emily A. Wu, James W. Horner and Ronald A. DePinho
doi:10.1038/35092592
First paragraph | Full Text | PDF (243K) | Supplementary information