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Nature 412, 865-866 (30 August 2001) |
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Project Manager – Scientist in Emulsions and Foams
- Nestle Research Center
- Lausanne, Switzerland
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- Fisheries and Oceans Canada (DFO)
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Achilles' heel of cancer?
Bert Vogelstein1 & Kenneth W. Kinzler1
Abstract
The p53 protein is inactivated in most human cancers. One outcome is a defect in controlling cell division. Might a virus that exploits this defect prove useful in treating cancer?
A decade or so ago, it was discovered that the p53 protein is subtly mutated, and thereby inactivated, in almost all types of human cancer1, 2. These findings raised the exciting possibility that drugs that restore p53's function would be broadly applicable cancer treatments.
- Bert Vogelstein and Kenneth W. Kinzler are at the Howard Hughes Medical Institute and Johns Hopkins Oncology Center, Baltimore, Maryland 21231, USA.
e-mail: Email: vogelbe@welch.jhu.edu and Email: kinzlke@welch.jhu.edu
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