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Nature 412, 780-781 (23 August 2001) | doi:10.1038/35090677

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Developmental biology: Clocks and Hox

Clifford J. Tabin1 & Randy L. Johnson2

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Segmentation is a key feature of many animals. New molecular studies add to our understanding of how vertebrate segments form and how this process is linked to the genes that make each segment unique.

In vertebrates, the spine, ribcage and breastbone are derived from repeated blocks of tissue that begin as identical units in early development and are then modified into unique shapes with different purposes. Some segments, for example, allow the head to move; some are sites of attachment for the muscles involved in breathing; and some protect the organs in the chest.

  1. Clifford J. Tabin is in the Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA.
    e-mail: Email: tabin@rascal.med.harvard.edu
  2. Randy L. Johnson is in the Department of Biochemistry and Molecular Biology, University of Texas, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA.
    e-mail: Email: rjohnson@odin.mdacc.tmc.edu