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Nature 412, 133-135 (12 July 2001) | doi:10.1038/35084313
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Assistant or Associate Professor, Section of Anatomic Pathology
- The Medical College of Georgia
- Augusta, Georgia, USA
Professor / Associate Professor (Pharmaceutics / Pharmaceutical Analysis&quality Control)
- Alliance Institute of Advanced Pharmacy and Health Sciences
- Hyderabad 500038 India
Apoptosis: Mostly dead
Douglas R. Green1 & Helen M. Beere1
Abstract
It has always been thought that once the process of cell suicide has passed a certain point, it is irreversible. Yet it seems that cells can recover — but only if they are not eaten by nearby 'phagocytic' cells.
In all animals, the process of programmed cell suicide (apoptosis) is coordinated by enzymes known as caspases, which cut up key substrates in the cell. The dying cell is then neatly packaged, engulfed by neighbouring 'phagocytic' cells, and cleared from the body without fanfare, leaving no evidence of the catastrophic events that preceded.
- Douglas R. Green and Helen M. Beere are at the La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92121, USA.
Correspondence to: Douglas R. Green1 e-mail: Email: dgreen5240@aol.com
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