Table of contents
Volume 411 Number 6841 pp3-1081
(this content only available online) indicates content that is available online only
Opinion
Defending tax-funded navigation p977
A congressional committee has erred in its appropriate desire to support free enterprise.
News
Physicist nominated as science adviser for US administration p979
Tony Reichhardt
doi:10.1038/35082710
Budget proposal casts doubt over physics portal's future p980
Declan Butler
doi:10.1038/35082713
Poor nations push for right to produce cheap medicines p982
Sally Goodman
doi:10.1038/35082723
India blocks sale of transgenic cotton seeds p983
K. S. Jayaraman
doi:10.1038/35082729
news feature
Brane new world p986
Some theorists propose that our Universe exists as a slice through multidimensional space. Could this 'brane-world' concept unify gravity with nature's other fundamental forces? Roland Pease reports.
Roland Pease
doi:10.1038/35082684
Vital signs p989
The science of biomonitoring, which uses living organisms as 'sensors' to track environmental pollution, seems to be coming of age. John Whitfield considers its potential.
John Whitfield
doi:10.1038/35082694
Book Reviews
A dark side of automation p993
doi:10.1038/35082640
Who is out there? p994
Don Brownlee reviews Search for Life/Astrobiology by Monica Grady
doi:10.1038/35082643
Life at the extremes p994
doi:10.1038/35082645
The view from Japan p995
Marc Bekoff & Jane Goodall review Primate Origins of Human Cognition and Behavior
doi:10.1038/35082648
Science in culture p996
Alison Abbott reviews
doi:10.1038/35082651
words
Archaeology of type p997
Printing technology co-evolved with the written representation of language.
Blaise Agüera y Arcas & Adrienne Fairhall
doi:10.1038/35082698
News and Views
Are all cancer genes equal? p1001
Cancer arises because of the accumulation of defects in certain classes of genes. In mice, breast tumours caused by one such class of 'cancer genes' can be prevented.
Jiri Bartek & Jiri Lukas
doi:10.1038/35082655
Astronomy: Planetary candidates p1002
The tentative discovery of planets roaming freely through interstellar space has far-reaching implications. If confirmed, it would imply that there are more planets on the loose than there are around stars.
Bohdan Paczynski
doi:10.1038/35082658
Biological catalysis: Repopulating the RNA world p1003
We will probably never be certain how life on our planet began. But, thanks to a new laboratory study, the possibility of an ancient 'RNA world' appears more plausible.
Scott A. Strobel
doi:10.1038/35082661
Geophysics: Martian motion p1005
Tim Lincoln
doi:10.1038/35082664
Cell biology: Glowing switches p1006
An approach involving changes in the emission of fluorescence reveals new information about the activation of two important molecular switches in real time and space.
Johannes L. Bos
doi:10.1038/35082667
Communications technology: A bottleneck for optical fibres p1007
Optical fibres carry light signals at extremely high frequencies, and offer enormous bandwidth for transmitting data. But nonlinear effects may limit their capacity to carry information.
Joseph M. Kahn & Keang-Po Ho
doi:10.1038/35082671
100 and 50 years ago p1009
doi:10.1038/35082674
Immunology: T cells and tumours p1010
The immune system's response to new tumours is complicated but seems to depend on where and when tumours develop. This will have to be much better understood to enlist a patient's immune defences in fighting cancer.
Drew Pardoll
doi:10.1038/35082676
Quantum engineering: Catch the atom p1010
Liesbeth Venema
doi:10.1038/35082679
Daedalus: Phones and the brain p1012
David Jones
doi:10.1038/35082682
Brief Communications
Genomics: Genes lost during evolution p1013
Jeroen Roelofs & Peter J. M. Van Haastert
doi:10.1038/35082627
First paragraph | Full Text | PDF (141K) | Supplementary information
Night-time predation by Steller sea lions p1013
New insight into the feeding habits of these mammals will help conservation attempts.
Gary L. Thomas & Richard E. Thorne
doi:10.1038/35082745
Bone-marrow transplantation: Failure to correct murine muscular dystrophy p1014
Giuliana Ferrari, Anna Stornaiuolo & Fulvio Mavilio
doi:10.1038/35082631
First paragraph | Full Text | PDF (126K)
Microclimate: Formation of ozone by fireworks p1015
Arun K. Attri, Ujjwal Kumar & V. K. Jain
doi:10.1038/35082634
First paragraph | Full Text | PDF (94K)
Laminar flows: Subcellular positioning of small molecules p1016
Shuichi Takayama, Emanuele Ostuni, Philip LeDuc, Keiji Naruse, Donald E. Ingber & George M. Whitesides
doi:10.1038/35082637
First paragraph | Full Text | PDF (132K)
Article
Specific protection against breast cancers by cyclin D1 ablation p1017
Qunyan Yu, Yan Geng & Piotr Sicinski
doi:10.1038/35082500
Abstract | Full Text | PDF (358K)
See also: Opinion by
Letters to Nature
Gravitational microlensing by low-mass objects in the globular cluster M22 p1022
Kailash C. Sahu, Stefano Casertano, Mario Livio, Ronald L. Gilliland, Nino Panagia, Michael D. Albrow & Mike Potter
doi:10.1038/35082507
First paragraph | Full Text | PDF (155K)
See also: News and Views by Paczynski
Sub-poissonian loading of single atoms in a microscopic dipole trap p1024
Nicolas Schlosser, Georges Reymond, Igor Protsenko & Philippe Grangier
doi:10.1038/35082512
First paragraph | Full Text | PDF (198K)
See also: News and Views by Venema
Nonlinear limits to the information capacity of optical fibre communications p1027
Partha P. Mitra & Jason B. Stark
doi:10.1038/35082518
First paragraph | Full Text | PDF (152K)
See also: News and Views by Kahn & Ho
Control of conformational and interpolymer effects in conjugated polymers p1030
J. Kim & T. M. Swager
doi:10.1038/35082528
First paragraph | Full Text | PDF (474K) | Supplementary information
Biodegradation of oil in uplifted basins prevented by deep-burial sterilization p1034
A. Wilhelms, S. R. Larter, I. Head, P. Farrimond, R. di-Primio & C. Zwach
doi:10.1038/35082535
First paragraph | Full Text | PDF (157K) | Supplementary information
Mineral disequilibrium in lavas explained by convective self-mixing in open magma chambers p1037
S. Couch, R. S. J. Sparks & M. R. Carroll
doi:10.1038/35082540
First paragraph | Full Text | PDF (235K)
Anaerobic benzene oxidation coupled to nitrate reduction in pure culture by two strains of Dechloromonas p1039
John D. Coates, Romy Chakraborty, Joseph G. Lack, Susan M. O'Connor, Kimberly A. Cole, Kelly S. Bender & Laurie A. Achenbach
doi:10.1038/35082545
First paragraph | Full Text | PDF (198K)
Life-history traits of voles in a fluctuating population respond to the immediate environment p1043
Torbjørn Ergon, Xavier Lambin & Nils Chr. Stenseth
doi:10.1038/35082553
First paragraph | Full Text | PDF (200K) | Supplementary information
Protein dispensability and rate of evolution p1046
Aaron E. Hirsh & Hunter B. Fraser
doi:10.1038/35082561
First paragraph | Full Text | PDF (173K)
The contribution of sensory experience to the maturation of orientation selectivity in ferret visual cortex p1049
Leonard E. White, David M. Coppola & David Fitzpatrick
doi:10.1038/35082568
First paragraph | Full Text | PDF (366K) | Supplementary information
A defined range of guard cell calcium oscillation parameters encodes stomatal movements p1053
Gethyn J. Allen, Sarah P. Chu, Carrie L. Harrington, Karin Schumacher, Thomas Hoffmann, Yat Y. Tang, Erwin Grill & Julian I. Schroeder
doi:10.1038/35082575
First paragraph | Full Text | PDF (446K) | Supplementary information
Roles of tumour localization, second signals and cross priming in cytotoxic T-cell induction p1058
Adrian F. Ochsenbein, Sophie Sierro, Bernhard Odermatt, Marcus Pericin, Urs Karrer, Jan Hermans, Silvio Hemmi, Hans Hengartner & Rolf M. Zinkernagel
doi:10.1038/35082583
First paragraph | Full Text | PDF (574K) | Supplementary information
See also: News and Views by Pardoll
Spatio-temporal images of growth-factor-induced activation of Ras and Rap1 p1065
Naoki Mochizuki, Shigeko Yamashita, Kazuo Kurokawa, Yusuke Ohba, Takeharu Nagai, Atsushi Miyawaki & Michiyuki Matsuda
doi:10.1038/35082594
First paragraph | Full Text | PDF (354K) | Supplementary information
See also: News and Views by Bos
Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms p1068
Van Q. Nguyen, Carl Co & Joachim J. Li
doi:10.1038/35082600
First paragraph | Full Text | PDF (453K) | Supplementary information
Multiple pathways cooperate in the suppression of genome instability in Saccharomyces cerevisiae p1073
Kyungjae Myung, Clark Chen & Richard D. Kolodner
doi:10.1038/35082608
First paragraph | Full Text | PDF (151K)
Crystal structure of a complex of a type IA DNA topoisomerase with a single-stranded DNA molecule p1077
Anita Changela, Russell J. DiGate & Alfonso Mondragón
doi:10.1038/35082615
First paragraph | Full Text | PDF (457K) | Supplementary information
correction: A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis p1081
Srinivasa M. Srinivasula, Ramesh Hegde, Ayman Saleh, Pinaki Datta, Eric Shiozaki, Jijie Chai, Ryung-Ah Lee, Paul D. Robbins, Teresa Fernandes-Alnemri, Yigong Shi & Emad S. Alnemri
doi:10.1038/35082622
