Paul Smaglik
doi:10.1038/35108130
Table of contents
Volume 411 Number 6840 pp3-976
Top of page
Careers and Recruitment
Regions
Naturejobs
prospectsWarming up Scandinavia p3
Careers and Recruitment
From bench to bedside and back? p4
US academic health centres face challenges that may threaten the future vitality of the clinical research enterprise, but they are fighting back, says Diane Gershon.
Diane Gershon
doi:10.1038/35108132
From bench to bedside and back? p6
The movement of clinical trials from the public to the private sector is forcing academic health centres to re-examine their role.
Diane Gershon
doi:10.1038/35108137
Too few doctors p7
Increased demand by public healthcare for an already dwindling number of doctors has resulted in a low supply of clinical researchers in France, says Catherine Tastemain.
Catherine Tastemain
doi:10.1038/35108140
UK working for a better clinical climate p8
Regions
Bridging sectors Medicon Valley p10
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Opinion
Storm clouds over Brussels p871
Europe's research commissioner should develop a bolder vision for his 'European Research Area', while explicitly addressing the conflicting demands on the European Union's research programme.
doi:10.1038/35082193
Some advice for the president p871
George W. Bush needs a scientific adviser even more than the US research community needs a voice in the White House.
doi:10.1038/35082195
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News
Database of molecular probes set to boost chemical genetics p873
Asthma study death spurs inquiry p873
Texas facilities count cost of tropical storm p874
Congress cautious on advice office p874
Japan aims to forge stronger European links p875
Stem-cell research delayed by German ethics council p875
Ruling makes it harder to convict dig thieves p876
Deputies caught on the wrong side of the law p876
Europe plans concessions to kick-start Kyoto p877
Flavour switching solves riddle of missing neutrinos p877
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news feature
Raking through the embers p880
Clues about the origin and fate of the Universe lie hidden in the microwave radiation left over from its early days. Tom Clarke examines the latest attempts to map the Big Bang's afterglow.
Tom Clarke
doi:10.1038/35082152
The search for autism's roots p882
A marked rise in the number of people diagnosed with autism sparked controversy over the safety of certain vaccines. As the furore dies down, Kathleen Wong talks to researchers seeking the real causes of this unsettling condition.
Kathleen Wong
doi:10.1038/35082228
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Correspondence
Poetry tells us that our souls have a shadow: can science respond? p885
Call to work together on microarray data analysis p885
Medical luminaries p885
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Book Reviews
Speaking of learning p887
How do we acquire our marvellous facility for expressing ourselves in words?
doi:10.1038/35082123
The birth of matter p888
doi:10.1038/35082126
Geometry down the centuries p888
doi:10.1038/35082129
Universal knowledge p889
doi:10.1038/35082131
New in paperback p889
doi:10.1038/35082133
Star-gazing made easy p890
doi:10.1038/35082135
New Journals p890
doi:10.1038/35082138
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words
Risk and uncertainty p891
At the frontiers of science, we don't always know what may happen.
Robert May
doi:10.1038/35082158
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News and Views
柔らかい物質：くっつかない水
Non-stick water p895
Adding a simple powder to a drop of water gives it remarkable properties: the powder-coated drop no longer sticks to surfaces, and moves by rolling, much as a solid sphere would.
L. Mahadevan
doi:10.1038/35082164
構造生物学：クロロフィルがいっぱい
Structural biology: Chlorophylls galore p896
A high-resolution crystal structure of photosystem I, part of the machinery that performs photosynthesis, reveals how an extensive array of chlorophylls uses solar energy to transport electrons.
Werner Kühlbrandt
doi:10.1038/35082169
100 and 50 years ago p897
天文学：小惑星帯の巨人
Astronomy: Giants in the asteroid belt p899
Models of Solar System formation have always had a hard time explaining the mysterious asteroid belt. By injecting new life into an old myth about the origin of asteroids, astronomers may now have the answer.
Derek C. Richardson
doi:10.1038/35082174
進化生物学：種分化の三角関係
Evolutionary biology: Seeing red in speciation p900
Mating patterns in sticklebacks have been investigated for over fifty years. The latest studies show how a complex interplay between males, females and the environment can contribute to the formation of new species.
Michael J. Ryan
doi:10.1038/35082176
凝縮系物理学：ニッケルで探る超伝導
Condensed-matter physics: Nickel probes superconductivity p901
Magnetism usually destroys superconductivity, but a magnetic nickel atom inserted into a high-temperature superconductor has surprisingly little effect on its local environment.
Michael E. Flatté
doi:10.1038/35082179
神経科学：空間の認識
Neuroscience: Awareness of space p903
Damage to particular parts of the brain can cause spatial confusion and even eliminate awareness of areas of space around the body. The brain regions responsible for spatial awareness, however, are still under debate.
Michael S. A. Graziano
doi:10.1038/35082182
生態学：受け入れがたい減少
Ecology: Dairy declines hard to swallow p904
Birds are important constituents of any ecosystem. But they are also valuable monitors of environmental conditions — if their populations begin to decline, we need to know why.
Peter D. Moore
doi:10.1038/35082185
Daedalus: Stored rail energy p905
Obituary: Frederick Gillett (1937–2001) p906
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Brief Communications
The web of human sexual contacts p907
Promiscuous individuals are the vulnerable nodes to target in safe-sex campaigns.
Fredrik Liljeros, Christofer R. Edling, Luís A. Nunes Amaral, H. Eugene Stanley and Yvonne Åberg
doi:10.1038/35082140
Biomechanics: Turning the key on Drosophila audition p908
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Article
生化学：シアノバクテリア光化学系Iの分解能2.5Åの三次元構造
Three-dimensional structure of cyanobacterial photosystem I at 2.5 Å resolution p909
Patrick Jordan,
Petra Fromme,
Horst Tobias Witt,
Olaf Klukas,
Wolfram Saenger
and
Norbert Krau
doi:10.1038/35082000
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Interplay of magnetism and high-Tc superconductivity at individual Ni impurity atoms in Bi2Sr2CaCu2O8+
Nodulation of legumes by members of the
Letters to Nature
物理：強磁性のボース・アインシュタイン凝縮体中のスカーミオン
Skyrmions in a ferromagnetic Bose–Einstein condensate p918
物性：Bi2Sr2CaCu2O8+δ中に点在するNi不純物原子上での磁性と高Tc超伝導の相互作用
Interplay of magnetism and high-Tc superconductivity at individual Ni impurity atoms in Bi2Sr2CaCu2O8+
p920
E. W. Hudson, K. M. Lang, V. Madhavan, S. H. Pan, H. Eisaki, S. Uchida and J. C. Davis
doi:10.1038/35082019
日本語要約 | Full Text | PDF (326K)
化学：液体ビー玉
Liquid marbles p924
地球：フェロー堆の水路を通りノルディック海から大西洋へあふれ出る水の1950年以来の減少
Decreasing overflow from the Nordic seas into the Atlantic Ocean through the Faroe Bank channel since 1950 p927
Bogi Hansen, William R. Turrell and Svein Østerhus
doi:10.1038/35082034
日本語要約 | Full Text | PDF (441K)
地球：密度の逆転と下部地殻の噴出による変成コアコンプレックスの形成
Metamorphic core complex formation by density inversion and lower-crust extrusion p930
Fernando Martinez, Andrew M. Goodliffe and Brian Taylor
doi:10.1038/35082042
日本語要約 | Full Text | PDF (475K)
地球：地球マントルの温度圧力におけるMgSiO3ペロフスカイトの弾性定数
The elastic constants of MgSiO3 perovskite at pressures and temperatures of the Earth's mantle p934
Artem R. Oganov, John P. Brodholt and G. David Price
doi:10.1038/35082048
日本語要約 | Full Text | PDF (753K)
進化：主要な菌類系統の祖先は地衣類として共生していた
Major fungal lineages are derived from lichen symbiotic ancestors p937
François Lutzoni, Mark Pagel and Valérie Reeb
doi:10.1038/35082053
遺伝：系統発生解析では細菌から脊椎動物への遺伝子の水平移動の裏づけが得られない
Phylogenetic analyses do not support horizontal gene transfers from bacteria to vertebrates p940
Michael J. Stanhope, Andrei Lupas, Michael J. Italia, Kristin K. Koretke, Craig Volker and James R. Brown
doi:10.1038/35082058
進化：イトヨでは多様化した性選択が生殖隔離を増進させる
Divergent sexual selection enhances reproductive isolation in sticklebacks p944
進化：プロテオバクテリアβ亜綱の細菌によるマメ科植物の根粒形成
Nodulation of legumes by members of the 
-subclass of Proteobacteria p948
Lionel Moulin, Antonio Munive, Bernard Dreyfus and Catherine Boivin-Masson
doi:10.1038/35082070
日本語要約 | Full Text | PDF (398K)
認知：空間認識は側頭葉の機能であって後部頭頂葉の機能ではない
Spatial awareness is a function of the temporal not the posterior parietal lobe p950
Hans-Otto Karnath, Susanne Ferber and Marc Himmelbach
doi:10.1038/35082075
認知：前頭前野の個々のニューロンが抽象的ルールを符号化する
Single neurons in prefrontal cortex encode abstract rules p953
Jonathan D. Wallis, Kathleen C. Anderson and Earl K. Miller
doi:10.1038/35082081
日本語要約 | Full Text | PDF (330K)
生理：ブラジキニンや神経成長因子はカプサイシン受容体をPtdIns（4,5）P2による抑制から解放する
Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition p957
Huai-hu Chuang, Elizabeth D. Prescott, Haeyoung Kong, Shannon Shields, Sven-Eric Jordt, Allan I. Basbaum, Moses V. Chao and David Julius
doi:10.1038/35082088
生理：細胞内タンパク質Homerによって起こる、代謝調節型グルタミン酸受容体の作動体に依存しない活性化
Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer p962
F. Ango, L. Prézeau, T. Muller, J. C. Tu, B. Xiao, P. F. Worley, J. P. Pin, J. Bockaert and L. Fagni
doi:10.1038/35082096
日本語要約 | Full Text | PDF (261K)
発生：胚盤葉上層のNodal信号がマウス初期胚のパターン形成を行う
Nodal signalling in the epiblast patterns the early mouse embryo p965
Jane Brennan, Cindy C. Lu, Dominic P. Norris, Tristan A. Rodriguez, Rosa S. P. Beddington and Elizabeth J. Robertson
doi:10.1038/35082103
生理：遺伝毒性ストレス応答には、ATR/ATMを介したヒトRad17のリン酸化が必要である
ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses p969
Shideng Bao, Randal S. Tibbetts, Kathryn M. Brumbaugh, Yanan Fang, D. Ashley Richardson, Ambereen Ali, Susan M. Chen, Robert T. Abraham and Xiao-Fan Wang
doi:10.1038/35082110
日本語要約 | Full Text | PDF (295K)
correction: Gain-assisted superluminal light propagation p974
correction: Genomic analysis of metastasis reveals an essential role for RhoC p974
correction: Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses p974
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New on the Market
Protein growth area p975
Cunning plans such as distributed computing are speeding up proteomics.
doi:10.1038/35082147
