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Nature 411, 759-762 (14 June 2001) | doi:10.1038/35081138

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The ins and outs of signalling

Julian Downward

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The study of how cells communicate impinges on all aspects of biology, from development to disease. At first glance it's a horrendously complicated business, but some simple themes are emerging.

All cells must continually sense their surrounding environment and make decisions on the basis of that information. Single-celled organisms must be able to tell which nutrients are nearby and regulate their metabolic processes accordingly.