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Nature 411, 647-648 (7 June 2001) | doi:10.1038/35079715
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Cancer: Telomerase meets its mismatch
Raju Kucherlapati1 & Ronald A. DePinho2
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Abstract
Cells cannot survive without telomeres, the sequences that cap the ends of chromosomes, so cancer cells activate a telomere-generating enzyme. Studies of yeast now hint that they have a second way to make telomeres.
A human cell contains nearly six billion base pairs of DNA. With these huge numbers, it is almost inevitable that, during the lifetime of the cell, the DNA will accumulate errors, from either environmental influences or mistakes in DNA replication.
- Raju Kucherlapati is in the Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA.
e-mail: Email: kucherla@aecom.yu.edu - Ronald A. DePinho is at the Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA.
e-mail: Email: ron_depinho@dfci.harvard.edu
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