Table of contents

News

Data protection law threatens to derail UK epidemiology studies p509

David Adam

doi:10.1038/35079243

Arson hampers conservation work p509

Rex Dalton

doi:10.1038/35079246

Senate shift bodes well for 'green' science p510

Tony Reichhardt and Rex Dalton

doi:10.1038/35079248

Full Text | PDF (96K)

'Contrary' trade sanctions worry malaria researchers p510

Declan Butler

doi:10.1038/35079251

Full Text | PDF (96K)

NIH faces double trouble over budget rise p511

Matthew Davis

doi:10.1038/35079254

Full Text | PDF (197K)

Dust settles on defamation case p511

Rex Dalton

doi:10.1038/35079258

Full Text | PDF (197K)

Eastern Europe decries EU research proposal p512

Quirin Schiermeier

doi:10.1038/35079260

Full Text | PDF (113K)

Astronomers find fast-food plans hard to swallow p512

Sally Goodman

doi:10.1038/35079263

Full Text | PDF (113K)

Gene tests lift lid on drug-resistance puzzle p513

Jonathan Knight

doi:10.1038/35079266

Bioinformatics to be nurtured online p513

Declan Butler

doi:10.1038/35079269

news in brief p514

doi:10.1038/35079271

Full Text | PDF (71K)

news feature

A change of climate for big oil p516

As European environmentalists launch a boycott of US oil firms, other energy companies are winning praise for their efforts to tackle climate change. Mark Schrope examines the oil giants' divergent strategies.

Mark Schrope

doi:10.1038/35079275

Full Text | PDF (368K)

The North Sea bubble p518

David Adam

doi:10.1038/35079280

Full Text | PDF (85K)

Toronto's science jewel p519

A small Canadian institute is producing a disproportionate number of highly cited biology papers. Trisha Gura visited the Amgen Institute, to find out what its members are doing right.

Trisha Gura

doi:10.1038/35079195

Full Text | PDF (293K)

Correspondence

Free online availability substantially increases a paper's impact p521

Steve Lawrence

doi:10.1038/35079151

Full Text | PDF (72K)

Authors willing to pay for instant web access p521

Thomas J. Walker

doi:10.1038/35079154

Full Text | PDF (72K)

Impact factors, and why they won't go away p522

Eugene Garfield

doi:10.1038/35079156

Evolution is what's needed, not revolution p522

Colyn Crane-Robinson

doi:10.1038/35079158

The Net is many people's only chance of access p522

F. A. Khan

doi:10.1038/35079160

erratum: The self-archiving initiative p522

doi:10.1038/35079162

Book Reviews

No occupation for a gentleman p523

Is the urge to humiliate an opponent the true impetus for scientific progress?

Walter Gratzer reviews Rivals: Conflict as the Fuel of Science by Michael White

doi:10.1038/35079164

Full Text | PDF (238K)

Still waiting for the revolution p524

David Colquhoun reviews The Lady Tasting Tea: How Statistics Revolutionized Science in the Twentieth Century by David Salsburg

doi:10.1038/35079167

Full Text | PDF (212K)

Breaking down the barriers p525

Christophe Boesch reviews The Ape and the Sushi Master: Cultural Reflections by a Primatologist by Frans de Waal

doi:10.1038/35079170

Full Text | PDF (152K)

Science in culture p526

Giovanni F. Bignami reviews

doi:10.1038/35079173

Full Text | PDF (97K)

words

Formally speaking p527

Mathematical theorems can be created by formalization of everyday expressions.

John L. Casti

doi:10.1038/35079200

Full Text | PDF (148K)

concepts

Knife-edge of design p529

Jack Cohen

doi:10.1038/35079203

Full Text | PDF (206K)

News and Views

Entrepreneurial insects p531

Four British insect species have increased their geographical range as a result of climate warming. The underlying mechanisms vary from a change in food to an increase in habitat. Other species may not be quite so lucky.

Stuart L. Pimm

doi:10.1038/35079206

Full Text | PDF (128K)

100 and 50 years ago p532

doi:10.1038/35079210

Full Text | PDF (77K)

Superconductivity: Rehearsals for prime time p532

Superconductivity seems to have been forever waiting in the wings. Although superconducting power cables are about to go live, will the newest material, magnesium diboride, become the class act of the future?

Paul Grant

doi:10.1038/35079212

Full Text | PDF (77K)

Developmental biology: Fishing for morphogens p533

Morphogens are long-range signalling molecules that are proposed to organize tissue patterning in animals. But their existence in vertebrates has been controversial. One suspect is now shown to fit the bill.

Stephane Vincent and Norbert Perrimon

doi:10.1038/35079214

Full Text | PDF (224K)

Earth science: Mantle cookbook calibration p536

Doubts about a fundamental model of the chemistry of Earth's deep interior have now been transmuted into doubts about a standard used to calibrate these studies — gold's equation of state.

Craig R. Bina

doi:10.1038/35079218

Full Text | PDF (94K)

Behavioural ecology: Down on fungal farm p536

John Whitfield

doi:10.1038/35079220

Full Text | PDF (94K)

Human genetics: Tackling common disease p537

Crohn's disease is characterized by inflammation and destruction of the bowel. Identification of defective variants of a gene that predispose people to the disease is an encouraging development.

John A. Todd

doi:10.1038/35079223

Full Text | PDF (71K)

Chemistry: A new twist on molecular shape p539

What are the forces that control the twisting and folding of molecules into complex shapes? Don't look for the answers in your organic chemistry textbook.

Frank Weinhold

doi:10.1038/35079225

Full Text | PDF (140K)

Immunology: Brief encounter p541

To a certain extent, the response of immune cells to infection is preset. T cells seem to be activated early on or not at all, and, once stimulated, embark on a complete programme of division and specialization.

Raymond M. Welsh

doi:10.1038/35079229

Full Text | PDF (83K)

Cell biology: Channels as enzymes p542

The TRP family of ion channels is proving rather strange. The latest quirks of behaviour include a new enzymatic activity and second messenger, the ability to conduct magnesium ions, and an involvement in cell survival.

Michael D. Cahalan

doi:10.1038/35079231

Full Text | PDF (84K)

Daedalus: Four feet, one mouth p543

David Jones

doi:10.1038/35079234

Full Text | PDF (60K)

Obituary: G. N. Ramachandran (1922–2001) p544

M. Vijayan

doi:10.1038/35079236

Full Text | PDF (77K)

Brief Communications

Natural selection and resistance to HIV p545

A genotype that lowers susceptibility to HIV extends survival at a time of peak fertility.

Paul Schliekelman, Chad Garner and Montgomery Slatkin

doi:10.1038/35079176

Full Text | PDF (345K)

Climate change: Increasing shrub abundance in the Arctic p546

Matthew Sturm, Charles Racine and Kenneth Tape

doi:10.1038/35079180

First paragraph | Full Text | PDF (371K)

Sensory adaptation: Tunable colour vision in a mantis shrimp p547

Thomas W. Cronin, Roy L. Caldwell and Justin Marshall

doi:10.1038/35079184

First paragraph | Full Text | PDF (162K)

Developmental biology: Lungfish dental pattern conserved for 360 Myr p548

Robert R. Reisz and Moya M. Smith

doi:10.1038/35079187

First paragraph | Full Text | PDF (114K)

Article

Many-body and correlation effects in semiconductors p549

D. S. Chemla and Jagdeep Shah

doi:10.1038/35079000

Abstract | Full Text | PDF (530K)

Letters to Nature

High critical current density and enhanced irreversibility field in superconducting MgB₂ thin films p558

C. B. Eom, M. K. Lee, J. H. Choi, L. J. Belenky, X. Song, L. D. Cooley, M. T. Naus, S. Patnaik, J. Jiang, M. Rikel, A. Polyanskii, A. Gurevich, X. Y. Cai, S. D. Bu, S. E. Babcock, E. E. Hellstrom, D. C. Larbalestier, N. Rogado, K. A. Regan, M. A. Hayward, T. He, J. S. Slusky, K. Inumaru, M. K. Haas and R. J. Cava

doi:10.1038/35079018

First paragraph | Full Text | PDF (294K)

Enhancement of the high-magnetic-field critical current density of superconducting MgB₂ by proton irradiation p561

Y. Bugoslavsky, L. F. Cohen, G. K. Perkins, M. Polichetti, T. J. Tate, R. Gwilliam and A. D. Caplin

doi:10.1038/35079024

First paragraph | Full Text | PDF (234K)

High critical currents in iron-clad superconducting MgB₂ wires p563

S. Jin, H. Mavoori, C. Bower and R. B. van Dover

doi:10.1038/35079030

First paragraph | Full Text | PDF (204K)

Hyperconjugation not steric repulsion leads to the staggered structure of ethane p565

Vojislava Pophristic and Lionel Goodman

doi:10.1038/35079036

First paragraph | Full Text | PDF (219K)

Possible displacement of the climate signal in ancient ice by premelting and anomalous diffusion p568

A. W. Rempel, E. D. Waddington, J. S. Wettlaufer and M. G. Worster

doi:10.1038/35079043

First paragraph | Full Text | PDF (232K) | Supplementary information

The post-spinel transformation in Mg₂SiO₄ and its relation to the 660-km seismic discontinuity p571

Sang-Heon Shim, Thomas S. Duffy and Guoyin Shen

doi:10.1038/35079053

First paragraph | Full Text | PDF (217K) | Supplementary information

High-pressure polymorphs of olivine and the 660-km seismic discontinuity p574

L. Chudinovskikh and R. Boehler

doi:10.1038/35079060

First paragraph | Full Text | PDF (257K)

Ecological and evolutionary processes at expanding range margins p577

C. D. Thomas, E. J. Bodsworth, R. J. Wilson, A. D. Simmons, Z. G. Davies, M. Musche and L. Conradt

doi:10.1038/35079066

First paragraph | Full Text | PDF (248K)

Honeybee dances communicate distances measured by optic flow p581

Harald E. Esch, Shaowu Zhang, Mandyan V. Srinivasan and Juergen Tautz

doi:10.1038/35079072

First paragraph | Full Text | PDF (143K)

Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons p583

Mark A. Ungless, Jennifer L. Whistler, Robert C. Malenka and Antonello Bonci

doi:10.1038/35079077

First paragraph | Full Text | PDF (240K)

Presynaptic glycine receptors enhance transmitter release at a mammalian central synapse p587

Rostislav Turecek and Laurence O. Trussell

doi:10.1038/35079084

First paragraph | Full Text | PDF (386K) | Supplementary information

LTRPC7 is a MgATP-regulated divalent cation channel required for cell viability p590

Monica J. S. Nadler, Meredith C. Hermosura, Kazunori Inabe, Anne-Laure Perraud, Qiqin Zhu, Alexander J. Stokes, Tomohiro Kurosaki, Jean-Pierre Kinet, Reinhold Penner, Andrew M. Scharenberg and Andrea Fleig

doi:10.1038/35079092

First paragraph | Full Text | PDF (353K) | Supplementary information

ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology p595

Anne-Laure Perraud, Andrea Fleig, Christopher A. Dunn, Leigh Ann Bagley, Pierre Launay, Carsten Schmitz, Alexander J. Stokes, Qiqin Zhu, Maurice J. Bessman, Reinhold Penner, Jean-Pierre Kinet and Andrew M. Scharenberg

doi:10.1038/35079100

First paragraph | Full Text | PDF (271K) | Supplementary information

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease p599

Jean-Pierre Hugot, Mathias Chamaillard, Habib Zouali, Suzanne Lesage, Jean-Pierre Cézard, Jacques Belaiche, Sven Almer, Curt Tysk, Colm A. O'Morain, Miquel Gassull, Vibeke Binder, Yigael Finkel, Antoine Cortot, Robert Modigliani, Pierre Laurent-Puig, Corine Gower-Rousseau, Jeanne Macry, Jean-Frédéric Colombel, Mourad Sahbatou and Gilles Thomas

doi:10.1038/35079107

First paragraph | Full Text | PDF (170K)

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease p603

Yasunori Ogura, Denise K. Bonen, Naohiro Inohara, Dan L. Nicolae, Felicia F. Chen, Richard Ramos, Heidi Britton, Thomas Moran, Reda Karaliuskas, Richard H. Duerr, Jean-Paul Achkar, Steven R. Brant, Theodore M. Bayless, Barbara S. Kirschner, Stephen B. Hanauer, Gabriel Nuñez and Judy H. Cho

doi:10.1038/35079114

First paragraph | Full Text | PDF (327K)

The zebrafish Nodal signal Squint functions as a morphogen p607

Yu Chen and Alexander F. Schier

doi:10.1038/35079121

First paragraph | Full Text | PDF (345K) | Supplementary information

MOR1 is essential for organizing cortical microtubules in plants p610

Angela T. Whittington, Oliver Vugrek, Ke Jun Wei, Nortrud G. Hasenbein, Keiko Sugimoto, Madeleine C. Rashbrooke and Geoffrey O. Wasteneys

doi:10.1038/35079128

First paragraph | Full Text | PDF (472K) | Supplementary information

Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor p613

Tetsuya Ohtaki, Yasushi Shintani, Susumu Honda, Hirokazu Matsumoto, Akira Hori, Kimiko Kanehashi, Yasuko Terao, Satoshi Kumano, Yoshihiro Takatsu, Yasushi Masuda, Yoshihiro Ishibashi, Takuya Watanabe, Mari Asada, Takao Yamada, Masato Suenaga, Chieko Kitada, Satoshi Usuki, Tsutomu Kurokawa, Haruo Onda, Osamu Nishimura and Masahiko Fujino

doi:10.1038/35079135

First paragraph | Full Text | PDF (285K) | Supplementary information

erratum: Self-assembly of mesoscopically ordered chromatic polydiacetylene/silica nanocomposites p617

Yunfeng Lu, Yi Yang, Alan Sellinger, Mengcheng Lu, Jinman Huang, Hongyou Fan, Raid Haddad, Gabriel Lopez, Alan R. Burns, Darryl Y. Sasaki, John Shelnutt and C. Jeffrey Brinker

doi:10.1038/35079144

Full Text | PDF (767K)

correction: Formation cross-sections of singlet and triplet excitons in -conjugated polymers p617

M. Wohlgenannt, Kunj Tandon, S. Mazumdar, S. Ramasesha and Z. V. Vardeny

doi:10.1038/35079146

Full Text | PDF (767K)

correction: Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses p617

Carin C. Stamper, Yan Zhang, James F. Tobin, David V. Erbe, Shinji Ikemizu, Simon J. Davis, Mark L. Stahl, Jasbir Seehra, William S. Somers and Lidia Mosyak

doi:10.1038/35079149

Full Text | PDF (767K)