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Nature 411, 537-539 (31 May 2001) | doi:10.1038/35079223
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Human genetics: Tackling common disease
John A. Todd
Abstract
Crohn's disease is characterized by inflammation and destruction of the bowel. Identification of defective variants of a gene that predispose people to the disease is an encouraging development.
The 1980s saw the identification of the genes which, when mutated, cause rare, inherited diseases such as cystic fibrosis that follow straightforward patterns of inheritance. The 1990s promised similar conquests in understanding the more common diseases (defined as more than one case per 1,000 people) that have a more complex genetic basis.
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