Paul Smaglik
doi:10.1038/35108050
Table of contents
Volume 411 Number 6835 pp3-398
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regions
movers
Naturejobs
prospectsPanning for gold p3
regions
The birthplace of biotech California p4
movers
Computer science, biotech, space science, genomics p6
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Opinion
A call to arms p223
Biologists should involve themselves in the debate over biological weapons — both to ensure that we have the means to counter the threats that such weapons pose and to help keep those threats in perspective.
doi:10.1038/35077267
Nature's world view p223
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News
Espionage charges threaten to undermine research relations p225
United States treads its own path on climate change p225
Record salmon populations disguise uncertain future p226
Californian labs feel the heat of energy crisis p227
Angry researchers pour scorn on astrology classes p227
Epidemiology gains an ally in bioweapons surveillance project p228
Array system promises global atmospheric monitoring p228
Fresh funding offers lifeline to bioinformatics centre p229
Physicists put a value that matters on the standard model p229
Resuscitated 'alien' microbes stir up an Italian storm p229
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news feature
The bugs of war p232
Could our knowledge of microbial genomics and skill in genetic engineering be used to create 'enhanced' bioweapons? Carina Dennis assesses the threat, and the efforts to counter it.
Carina Dennis
doi:10.1038/35077161
A fine set of threads p236
Ultra-thin fibres spun from polymers could be used to protect against chemical weapons, dress wounds and make brakes for aircraft. David Adam tells a gripping yarn.
David Adam
doi:10.1038/35077170
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Correspondence
Hero or villain? Stasi archives shed light on Russian scientist p237
Sorting out the Smiths p237
Health-funding boost not enough for Canada p237
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Book Reviews
Why science and religion need to talk p239
Human 'fallenness', freedom and pain are the preserve of both arenas.
doi:10.1038/35077129
Hopping through the Mathiverse p240
doi:10.1038/35077133
Affairs of the mind p241
doi:10.1038/35077137
Science in culture p242
doi:10.1038/35077139
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words
Sense and sensibility p243
Could literature teach us how to release scientific writing from its straitjacket?
Robert Simmons
doi:10.1038/35077175
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News and Views
地球変動：葉のセンサーで探る太古のCO2
Leaf sensor for CO2 in deep time p247
How long have CO2 and climate been linked? At least 300 million years, according to the results of a neat technique that exploits the relationship between concentrations of CO2 in the atmosphere and pores in leaves.
Wolfram M. Kürschner
doi:10.1038/35077181
記憶：覚えるのに時間がかかる理由
Memory: Why is the cortex a slow learner? p248
Mice that have only half the normal amount of a synaptic protein called 
-CaMKII learn normally, but remember poorly. The result sheds light on the mysterious mechanisms of memory consolidation.
John Lisman and Richard Morris
doi:10.1038/35077185
100 and 50 years ago p249
天文物理学：スターの演技
Astrophysics: A stellar performance p251
Using a network of telescopes spread across the United States, astronomers have made a movie of an expanding shell of gas that sheds light on the intricate processes of how a star is born.
Kevin B. Marvel
doi:10.1038/35077189
神経生物学：でんでん虫・シナプス・スモーカー
Neurobiology: Snails, synapses and smokers p252
The discovery of a protein that controls the transmission of nerve impulses in snails is significant in its own right. It also advances our understanding of the vertebrate neurotransmitter receptor that responds to nicotine.
Dennis A. Dougherty and Henry A. Lester
doi:10.1038/35077192
マイクロマシン：ひずみを利用した機械
Micromachines: Strain against the machine p252
発生生物学：表か裏か
Developmental biology: Making head or tail of Dickkopf p255
Signals that guide embryonic cells through development are often under the control of inhibitors. It now seems that one such inhibitor does not bind to the signal itself, but rather to the receptor that detects the signal.
Roel Nusse
doi:10.1038/35077199
Daedalus: Watching the wind p256
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Brief Communications
Sex differences in vocal learning in birds p257
Young females pick up songs much faster than males but are not so versatile later on.
Ayako Yamaguchi
doi:10.1038/35077143
Biogeochemistry: Phosphorus solubilization in rewetted soils p258
Benjamin L. Turner and Philip M. Haygarth
doi:10.1038/35077146
Epidemiology: Foot-and-mouth disease under control in the UK p258
Mark Woolhouse, Margo Chase-Topping, Daniel Haydon, John Friar, Louise Matthews, Gareth Hughes, Darren Shaw, John Wilesmith, Alex Donaldson, Stephen Cornell, Matthew Keeling and Bryan Grenfell
doi:10.1038/35077149
Genomics: Annotation of the Drosophila genome p259
Samuel Karlin, Aviv Bergman and Andrew J. Gentles
doi:10.1038/35077152
erratum: Flexible style that encourages outcrossing p260
doi:10.1038/35077155
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Articles
神経：シナプス伝達を調節するグリア由来アセチルコリン結合タンパク質
A glia-derived acetylcholine-binding protein that modulates synaptic transmission p261
August B. Smit,
Naweed I. Syed,
Dick Schaap,
Jan van Minnen,
Judith Klumperman,
Karel S. Kits,
Hans Lodder,
Roel C. van der Schors,
René van Elk,
Bertram Sorgedrager,
Katju
a Brejc,
Titia K. Sixma
and
Wijnand P. M. Geraerts
doi:10.1038/35077000
生化学：ACh結合タンパク質の結晶構造から明らかになったニコチン性受容体のリガンド結合ドメイン
Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors p269
Katjua Brejc,
Willem J. van Dijk,
Remco V. Klaassen,
Mascha Schuurmans,
John van der Oost,
August B. Smit
and
Titia K. Sixma
doi:10.1038/35077011
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Letters to Nature
宇宙：若い恒星からの球状で一時的な物質噴出
Spherical episodic ejection of material from a young star p277
J. M. Torrelles, N. A. Patel, J. F. Gómez, P. T. P. Ho, L. F. Rodríguez, G. Anglada, G. Garay, L. Greenhill, S. Curiel and J. Cantó
doi:10.1038/35077020
日本語要約 | Full Text | PDF (449K)
物理：超流体4Heでの理想的なジョセフソン効果の観測
Observation of the ideal Josephson effect in superfluid 4He p280
Kalyani Sukhatme, Yury Mukharsky, Talso Chui and David Pearson
doi:10.1038/35077024
日本語要約 | Full Text | PDF (544K)
材料：大気圧下で炭化ケイ素を結晶性ダイヤモンド構造炭素に転換
Conversion of silicon carbide to crystalline diamond-structured carbon at ambient pressure p283
Yury Gogotsi, Sascha Welz, Daniel A. Ersoy and Michael J. McNallan
doi:10.1038/35077031
環境：化石植物のクチクラから得た、大気中二酸化炭素の3億年の記録
A 300-million-year record of atmospheric carbon dioxide from fossil plant cuticles p287
気候：9000年前から6000年前のオマーンにおける、太陽変動とモンスーンとの強い相関
Strong coherence between solar variability and the monsoon in Oman between 9 and 6 kyr ago p290
U. Neff, S. J. Burns, A. Mangini, M. Mudelsee, D. Fleitmann and A. Matter
doi:10.1038/35077048
地球：沈み込んだ海洋堆積物の変成不揮発化と地球マントルへの揮発性物質の輸送
Metamorphic devolatilization of subducted marine sediments and the transport of volatiles into the Earth's mantle p293
D. M. Kerrick and J. A. D. Connolly
生態：長距離の渡りをする鳥類では、到着時期によって気候変動への適応が制限される
Adjustment to climate change is constrained by arrival date in a long-distance migrant bird p296
生態：貧毛類に内部共生する硫酸塩還元細菌と硫化物酸化細菌
Endosymbiotic sulphate-reducing and sulphide-oxidizing bacteria in an oligochaete worm p298
Nicole Dubilier, Caroline Mülders, Tim Ferdelman, Dirk de Beer, Annelie Pernthaler, Michael Klein, Michael Wagner, Christer Erséus, Frank Thiermann, Jens Krieger, Olav Giere and Rudolf Amann
doi:10.1038/35077067
生態：色模様の擬態で起こる生殖的隔離
Reproductive isolation caused by colour pattern mimicry p302
Chris D. Jiggins, Russell E. Naisbit, Rebecca L. Coe and James Mallet
doi:10.1038/35077075
認知：ヒトの扁桃体障害は情緒的に突出した事象についての認知強化を損なう
Lesions of the human amygdala impair enhanced perception of emotionally salient events p305
Adam K. Anderson and Elizabeth A. Phelps
doi:10.1038/35077083
神経：永久記憶に必要な、皮質におけるα-CaMKII依存的可塑性
-CaMKII-dependent plasticity in the cortex is required for permanent memory p309
Paul W. Frankland, Cara O'Brien, Masuo Ohno, Alfredo Kirkwood and Alcino J. Silva
doi:10.1038/35077089
日本語要約 | Full Text | PDF (262K)
生理：ショウジョウバエ概日発振源におけるクリプトクロムの新しい役割
A new role for cryptochrome in a Drosophila circadian oscillator p313
Balaji Krishnan, Joel D. Levine, M. Kathlea S. Lynch, Harold B. Dowse, Pablo Funes, Jeffrey C. Hall, Paul E. Hardin and Stuart E. Dryer
doi:10.1038/35077094
生理：海馬シナプスにおけるシナプス前後の機能成熟にインテグリンが関与
Integrins mediate functional pre- and postsynaptic maturation at a hippocampal synapse p317
発生：6型LDL受容体関連タンパク質はDickkopfタンパク質の受容体である
LDL-receptor-related protein 6 is a receptor for Dickkopf proteins p321
Bingyu Mao, Wei Wu, Yan Li, Dana Hoppe, Peter Stannek, Andrei Glinka and Christof Niehrs
doi:10.1038/35077108
日本語要約 | Full Text | PDF (244K)
発生：ニワトリ胚においてWnt信号の状態は神経と表皮の運命決定を調節する
The status of Wnt signalling regulates neural and epidermal fates in the chick embryo p325
Sara Wilson, Anna Rydström, Tolleiv Trimborn, Karl Willert, Roel Nusse, Thomas M. Jessell and Thomas Edlund
doi:10.1038/35077115
細胞：ショウジョウバエでは、MAPキナーゼによる転写因子Etsのリン酸化はMaeを介して起こる
Mae mediates MAP kinase phosphorylation of Ets transcription factors in Drosophila p330
David A. Baker, Blandine Mille-Baker, S. Mark Wainwright, David Ish-Horowicz and Nicholas J. Dibb
doi:10.1038/35077122
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progress
review article
progress
Corporate Support
insight
forewordCancer p335
progress
Cancer genetics p336
Proliferation, cell cycle and apoptosis in cancer p342
The Hedgehog and Wnt signalling pathways in cancer p349
review article
Oncogenic kinase signalling p355
Genome maintenance mechanisms for preventing cancer p366
progress
The microenvironment of the tumour–host interface p375
Progress in human tumour immunology and immunotherapy p380
Haematopoietic cell transplantation as immunotherapy p385
Cancer epidemiology in the last century and the next decade p390
Corporate Support
AstraZeneca and Cancer discovery from a global perspective p396
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New on the Market
Cultural revolutions p397
New ideas for the microbiologist include BugStoppers and bug counters.
doi:10.1038/35077157
