Naturejobs

Panning for gold p3

Paul Smaglik

doi:10.1038/35108050

Full Text | PDF (98K)

The birthplace of biotech California p4

Potter Wickware

doi:10.1038/35108052

Full Text | PDF (166K)

Computer science, biotech, space science, genomics p6

doi:10.1038/35108058

Full Text | PDF (63K)

Opinion

A call to arms p223

Biologists should involve themselves in the debate over biological weapons — both to ensure that we have the means to counter the threats that such weapons pose and to help keep those threats in perspective.

doi:10.1038/35077267

Full Text | PDF (59K)

Nature's world view p223

Introducing a survey of unprecedented scope.

doi:10.1038/35077269

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News

Espionage charges threaten to undermine research relations p225

Laura Bonetta and David Cyranoski

doi:10.1038/35077271

Full Text | PDF (205K)

United States treads its own path on climate change p225

Irwin Goodwin

doi:10.1038/35077274

Full Text | PDF (205K)

Record salmon populations disguise uncertain future p226

Julie Wakefield

doi:10.1038/35077276

Full Text | PDF (98K)

Californian labs feel the heat of energy crisis p227

Rex Dalton

doi:10.1038/35077279

Full Text | PDF (149K)

Angry researchers pour scorn on astrology classes p227

K. S. Jayaraman

doi:10.1038/35077282

Full Text | PDF (149K)

Epidemiology gains an ally in bioweapons surveillance project p228

Jonathan Knight

doi:10.1038/35077285

Full Text | PDF (125K)

Array system promises global atmospheric monitoring p228

David Cyranoski

doi:10.1038/35077287

Full Text | PDF (125K)

Fresh funding offers lifeline to bioinformatics centre p229

Declan Butler and Alison Abbott

doi:10.1038/35077290

Full Text | PDF (157K)

Physicists put a value that matters on the standard model p229

Josette Chen

doi:10.1038/35077293

Full Text | PDF (157K)

Resuscitated 'alien' microbes stir up an Italian storm p229

Alison Abbott

doi:10.1038/35077295

Full Text | PDF (157K)

news in brief p230

doi:10.1038/35077298

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news feature

The bugs of war p232

Could our knowledge of microbial genomics and skill in genetic engineering be used to create 'enhanced' bioweapons? Carina Dennis assesses the threat, and the efforts to counter it.

Carina Dennis

doi:10.1038/35077161

Full Text | PDF (462K)

A fine set of threads p236

Ultra-thin fibres spun from polymers could be used to protect against chemical weapons, dress wounds and make brakes for aircraft. David Adam tells a gripping yarn.

David Adam

doi:10.1038/35077170

Full Text | PDF (154K)

Correspondence

Hero or villain? Stasi archives shed light on Russian scientist p237

Uwe Hossfeld and Mark Walker

doi:10.1038/35077302

Full Text | PDF (55K)

Sorting out the Smiths p237

Andrew Bradbury

doi:10.1038/35077304

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Health-funding boost not enough for Canada p237

Ronald N. McElhaney

doi:10.1038/35077306

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Book Reviews

Why science and religion need to talk p239

Human 'fallenness', freedom and pain are the preserve of both arenas.

Charles L. Harper reviews Can a Darwinian Be a Christian? The Relationship Between Science and Religion by Michael Ruse and Paths from Science Towards God: The End of All Our Exploring by Arthur Peacocke

doi:10.1038/35077129

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Hopping through the Mathiverse p240

Lisa Lehrer Dive and Andrew Irvine review Flatterland: Like Flatland Only More So by Ian Stewart

doi:10.1038/35077133

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Affairs of the mind p241

Steven Rose reviews Thinks... by David Lodge

doi:10.1038/35077137

Full Text | PDF (499K)

Science in culture p242

Martin Kemp reviews

doi:10.1038/35077139

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words

Sense and sensibility p243

Could literature teach us how to release scientific writing from its straitjacket?

Robert Simmons

doi:10.1038/35077175

Full Text | PDF (210K)

concepts

Ecological forecasts p245

Gretchen C. Daily

doi:10.1038/35077178

Full Text | PDF (146K)

News and Views

Leaf sensor for CO₂ in deep time p247

How long have CO₂ and climate been linked? At least 300 million years, according to the results of a neat technique that exploits the relationship between concentrations of CO₂ in the atmosphere and pores in leaves.

Wolfram M. Kürschner

doi:10.1038/35077181

Full Text | PDF (220K)

Memory: Why is the cortex a slow learner? p248

Mice that have only half the normal amount of a synaptic protein called -CaMKII learn normally, but remember poorly. The result sheds light on the mysterious mechanisms of memory consolidation.

John Lisman and Richard Morris

doi:10.1038/35077185

Full Text | PDF (77K)

100 and 50 years ago p249

Max Born

doi:10.1038/35077187

Full Text | PDF (65K)

Astrophysics: A stellar performance p251

Using a network of telescopes spread across the United States, astronomers have made a movie of an expanding shell of gas that sheds light on the intricate processes of how a star is born.

Kevin B. Marvel

doi:10.1038/35077189

Full Text | PDF (418K)

Neurobiology: Snails, synapses and smokers p252

The discovery of a protein that controls the transmission of nerve impulses in snails is significant in its own right. It also advances our understanding of the vertebrate neurotransmitter receptor that responds to nicotine.

Dennis A. Dougherty and Henry A. Lester

doi:10.1038/35077192

Full Text | PDF (411K)

Micromachines: Strain against the machine p252

Josette Chen

doi:10.1038/35077196

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Developmental biology: Making head or tail of Dickkopf p255

Signals that guide embryonic cells through development are often under the control of inhibitors. It now seems that one such inhibitor does not bind to the signal itself, but rather to the receptor that detects the signal.

Roel Nusse

doi:10.1038/35077199

Full Text | PDF (309K)

Daedalus: Watching the wind p256

David Jones

doi:10.1038/35077202

Full Text | PDF (59K)

Brief Communications

Sex differences in vocal learning in birds p257

Young females pick up songs much faster than males but are not so versatile later on.

Ayako Yamaguchi

doi:10.1038/35077143

First paragraph | Full Text | PDF (113K)

Biogeochemistry: Phosphorus solubilization in rewetted soils p258

Benjamin L. Turner and Philip M. Haygarth

doi:10.1038/35077146

First paragraph | Full Text | PDF (131K)

Epidemiology: Foot-and-mouth disease under control in the UK p258

Mark Woolhouse, Margo Chase-Topping, Daniel Haydon, John Friar, Louise Matthews, Gareth Hughes, Darren Shaw, John Wilesmith, Alex Donaldson, Stephen Cornell, Matthew Keeling and Bryan Grenfell

doi:10.1038/35077149

First paragraph | Full Text | PDF (131K)

Genomics: Annotation of the Drosophila genome p259

Samuel Karlin, Aviv Bergman and Andrew J. Gentles

doi:10.1038/35077152

First paragraph | Full Text | PDF (107K)

erratum: Flexible style that encourages outcrossing p260

doi:10.1038/35077155

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Articles

A glia-derived acetylcholine-binding protein that modulates synaptic transmission p261

August B. Smit, Naweed I. Syed, Dick Schaap, Jan van Minnen, Judith Klumperman, Karel S. Kits, Hans Lodder, Roel C. van der Schors, René van Elk, Bertram Sorgedrager, Katjua Brejc, Titia K. Sixma and Wijnand P. M. Geraerts

doi:10.1038/35077000

Abstract | Full Text | PDF (461K) | Supplementary information

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors p269

Katjua Brejc, Willem J. van Dijk, Remco V. Klaassen, Mascha Schuurmans, John van der Oost, August B. Smit and Titia K. Sixma

doi:10.1038/35077011

Abstract | Full Text | PDF (1,041K)

See also: News and Views by Dougherty & Lester

Letters to Nature

Spherical episodic ejection of material from a young star p277

J. M. Torrelles, N. A. Patel, J. F. Gómez, P. T. P. Ho, L. F. Rodríguez, G. Anglada, G. Garay, L. Greenhill, S. Curiel and J. Cantó

doi:10.1038/35077020

First paragraph | Full Text | PDF (449K)

See also: News and Views by Marvel

Observation of the ideal Josephson effect in superfluid ⁴He p280

Kalyani Sukhatme, Yury Mukharsky, Talso Chui and David Pearson

doi:10.1038/35077024

First paragraph | Full Text | PDF (544K)

Conversion of silicon carbide to crystalline diamond-structured carbon at ambient pressure p283

Yury Gogotsi, Sascha Welz, Daniel A. Ersoy and Michael J. McNallan

doi:10.1038/35077031

First paragraph | Full Text | PDF (622K) | Supplementary information

A 300-million-year record of atmospheric carbon dioxide from fossil plant cuticles p287

Gregory J. Retallack

doi:10.1038/35077041

First paragraph | Full Text | PDF (180K) | Supplementary information

See also: News and Views by Kürschner

Strong coherence between solar variability and the monsoon in Oman between 9 and 6 kyr ago p290

U. Neff, S. J. Burns, A. Mangini, M. Mudelsee, D. Fleitmann and A. Matter

doi:10.1038/35077048

First paragraph | Full Text | PDF (185K) | Supplementary information

Metamorphic devolatilization of subducted marine sediments and the transport of volatiles into the Earth's mantle p293

D. M. Kerrick and J. A. D. Connolly

First paragraph | Full Text | PDF (369K) | Supplementary information

Adjustment to climate change is constrained by arrival date in a long-distance migrant bird p296

Christiaan Both and Marcel E. Visser

doi:10.1038/35077063

First paragraph | Full Text | PDF (169K)

Endosymbiotic sulphate-reducing and sulphide-oxidizing bacteria in an oligochaete worm p298

Nicole Dubilier, Caroline Mülders, Tim Ferdelman, Dirk de Beer, Annelie Pernthaler, Michael Klein, Michael Wagner, Christer Erséus, Frank Thiermann, Jens Krieger, Olav Giere and Rudolf Amann

doi:10.1038/35077067

First paragraph | Full Text | PDF (272K) | Supplementary information

Reproductive isolation caused by colour pattern mimicry p302

Chris D. Jiggins, Russell E. Naisbit, Rebecca L. Coe and James Mallet

doi:10.1038/35077075

First paragraph | Full Text | PDF (221K) | Supplementary information

Lesions of the human amygdala impair enhanced perception of emotionally salient events p305

Adam K. Anderson and Elizabeth A. Phelps

doi:10.1038/35077083

First paragraph | Full Text | PDF (156K) | Supplementary information

-CaMKII-dependent plasticity in the cortex is required for permanent memory p309

Paul W. Frankland, Cara O'Brien, Masuo Ohno, Alfredo Kirkwood and Alcino J. Silva

doi:10.1038/35077089

First paragraph | Full Text | PDF (262K)

See also: News and Views by Lisman  & Morris

A new role for cryptochrome in a Drosophila circadian oscillator p313

Balaji Krishnan, Joel D. Levine, M. Kathlea S. Lynch, Harold B. Dowse, Pablo Funes, Jeffrey C. Hall, Paul E. Hardin and Stuart E. Dryer

doi:10.1038/35077094

First paragraph | Full Text | PDF (380K) | Supplementary information

Integrins mediate functional pre- and postsynaptic maturation at a hippocampal synapse p317

Pascale Chavis and Gary Westbrook

doi:10.1038/35077101

First paragraph | Full Text | PDF (437K)

LDL-receptor-related protein 6 is a receptor for Dickkopf proteins p321

Bingyu Mao, Wei Wu, Yan Li, Dana Hoppe, Peter Stannek, Andrei Glinka and Christof Niehrs

doi:10.1038/35077108

First paragraph | Full Text | PDF (244K)

See also: News and Views by Nusse

The status of Wnt signalling regulates neural and epidermal fates in the chick embryo p325

Sara Wilson, Anna Rydström, Tolleiv Trimborn, Karl Willert, Roel Nusse, Thomas M. Jessell and Thomas Edlund

doi:10.1038/35077115

First paragraph | Full Text | PDF (546K) | Supplementary information

Mae mediates MAP kinase phosphorylation of Ets transcription factors in Drosophila p330

David A. Baker, Blandine Mille-Baker, S. Mark Wainwright, David Ish-Horowicz and Nicholas J. Dibb

doi:10.1038/35077122

First paragraph | Full Text | PDF (307K) | Supplementary information

insight

Cancer p335

Bernd Pulverer, Lesley Anson, Chris Surridge and Liz Allen

doi:10.1038/35077204

Full Text | PDF (96K)

Cancer genetics p336

Bruce A. J. Ponder

doi:10.1038/35077207

Abstract | Full Text | PDF (150K)

Proliferation, cell cycle and apoptosis in cancer p342

Gerard I. Evan and Karen H. Vousden

doi:10.1038/35077213

Abstract | Full Text | PDF (1,438K)

The Hedgehog and Wnt signalling pathways in cancer p349

Jussi Taipale and Philip A. Beachy

doi:10.1038/35077219

Abstract | Full Text | PDF (387K)

Oncogenic kinase signalling p355

Peter Blume-Jensen and Tony Hunter

doi:10.1038/35077225

Abstract | Full Text | PDF (553K)

Genome maintenance mechanisms for preventing cancer p366

Jan H. J. Hoeijmakers

doi:10.1038/35077232

Abstract | Full Text | PDF (431K)

The microenvironment of the tumour–host interface p375

Lance A. Liotta and Elise C. Kohn

doi:10.1038/35077241

Abstract | Full Text | PDF (290K)

Progress in human tumour immunology and immunotherapy p380

Steven A. Rosenberg

doi:10.1038/35077246

Abstract | Full Text | PDF (186K)

Haematopoietic cell transplantation as immunotherapy p385

Frederick R. Appelbaum

doi:10.1038/35077251

Abstract | Full Text | PDF (168K)

Cancer epidemiology in the last century and the next decade p390

Julian Peto

doi:10.1038/35077256

Abstract | Full Text | PDF (152K)

AstraZeneca and Cancer discovery from a global perspective p396

Les Hughes

doi:10.1038/35077264

Full Text | PDF (310K)

New on the Market

Cultural revolutions p397

New ideas for the microbiologist include BugStoppers and bug counters.

doi:10.1038/35077157

Full Text | PDF (156K)