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Nature 411, 366-374 (17 May 2001) | doi:10.1038/35077232
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Postdoc Immunology, Mucosal Immunology, Gastroenterology
- Erasmus University Medical Center
- Rotterdam, The Netherlands
Project Leader - Natural Food Preservation
- Nestle Research Center
- Lausanne 1026 Switzerland
review article Genome maintenance mechanisms for preventing cancer
Jan H. J. Hoeijmakers1
Abstract
The early notion that cancer is caused by mutations in genes critical for the control of cell growth implied that genome stability is important for preventing oncogenesis. During the past decade, knowledge about the mechanisms by which genes erode and the molecular machinery designed to counteract this time-dependent genetic degeneration has increased markedly. At the same time, it has become apparent that inherited or acquired deficiencies in genome maintenance systems contribute significantly to the onset of cancer. This review summarizes the main DNA caretaking systems and their impact on genome stability and carcinogenesis.
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