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Nature 411, 342-348 (17 May 2001) | doi:10.1038/35077213
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progress Proliferation, cell cycle and apoptosis in cancer
Gerard I. Evan1 & Karen H. Vousden2
Abstract
Beneath the complexity and idiopathy of every cancer lies a limited number of 'mission critical' events that have propelled the tumour cell and its progeny into uncontrolled expansion and invasion. One of these is deregulated cell proliferation, which, together with the obligate compensatory suppression of apoptosis needed to support it, provides a minimal 'platform' necessary to support further neoplastic progression. Adroit targeting of these critical events should have potent and specific therapeutic consequences.
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