Table of contents
Volume 410 Number 6831 pp3-1008
Naturejobs
ProspectsReinventing Naturejobs p3
Paul Smaglik
doi:10.1038/35108000
SPECIAL REPORT
Cell signalling p4
Alliance signals a fresh type of scientific research endeavour as the post-genomic face of 'big biology' gets under way. Diane Gershon investigates.
Diane Gershon
doi:10.1038/35108003
movers
Biotechnology, Physics, Computer Science p6
doi:10.1038/35108009
Opinion
Free and public expression p851
After a slow start, progress towards developing public repositories for gene expression data is poised to accelerate. For the many biologists working with DNA microarrays, that should be welcome news.
doi:10.1038/35073755
Science without a tinge of green p851
With no explanation, the first budget proposed by George W. Bush proposes drastic reductions in environmental research.
doi:10.1038/35073757
News
Astronomers concerned by plan to give NASA ground control p853
Tony Reichhardt
doi:10.1038/35073759
EU plans global positioning system p853
Jim Giles
doi:10.1038/35073762
Earth sciences and biodiversity fall victim to budget plan p854
Rex Dalton
doi:10.1038/35073764
Britain looks to wave-power site after researchers flee p854
David Adam
doi:10.1038/35073766
Search is on for underwater volcano p854
Rex Dalton
doi:10.1038/35073769
Cancer comes under scrutiny in fresh genomics initiative p855
Jonathan Knight
doi:10.1038/35073772
Blood product from cattle wins approval for use in humans p855
Corie Lok
doi:10.1038/35073775
Japan prepares to pitch for international fusion reactor p856
David Cyranoski
doi:10.1038/35073778
Swiss proteomics company aims to make big impact p856
Alison Abbott
doi:10.1038/35073781
Satellite will probe mutating seeds in space p857
David Cyranoski
doi:10.1038/35073784
Animal labs fearful over activists' plan to name names p857
Quirin Schiermeier and Alison Abbott
doi:10.1038/35073787
news feature
When the chips are down p860
DNA microarrays are transforming studies of gene expression. But some of the biologists flocking to exploit this powerful technology are not aware of its potential pitfalls. Jonathan Knight relates a cautionary tale.
Jonathan Knight
doi:10.1038/35073680
The story of O p862
Geochemists are having a hard time working out why the atmosphere of the early Earth appears to have lacked oxygen for so long. Jon Copley considers the competing theories.
Jon Copley
doi:10.1038/35073794
Correspondence
Biotech offers Africans a chance to create their own practical solutions p865
Jesse Machuka
doi:10.1038/35073684
Kansas science saved by teachers' good sense p865
Rollie J. Clem
doi:10.1038/35073686
Bright light of learning snuffed out in Breslau p865
Min-Liang Wong
doi:10.1038/35073688
New information on the biodiversity facility p865
Christoph L. Häuser
doi:10.1038/35073690
Commentary
A year of opportunity p867
Now is the time for the UK Food Standards Agency to flex its muscles.
doi:10.1038/35073692
Book Reviews
How persistence paid off p869
The struggle, delusion and arrogance of the character who found Java Man.
Douglas Palmer reviews The Man Who Found the Missing Link: Eugene Dubois and His Lifelong Quest to Prove Darwin Right/The Extraordinary Life of Eugene Dubois by Pat Shipman
Slaves to logic p870
John Naughton reviews The Universal Computer: The Road from Leibniz to Turing by Martin Davis and Computers Ltd: What They Really Can't Do by David Harel
Preserved for posterity p870
doi:10.1038/35073701
Light on a distant subject p871
Carla Cacciari reviews Star Clusters by Bruce W. Carney & William E. Harris
New Journals p871
doi:10.1038/35073707
Science in culture p872
Martin Kemp reviews
doi:10.1038/35073709
words
Strings and things p873
Language is stretched to its limits in an effort to describe mathematics.
Jon Turney
doi:10.1038/35073712
News and Views
The promise of protonics p877
Fuel cells seem a good alternative to dirty and wasteful combustion. But known electrolytes — the crucial component — all have flaws. A new solid-state proton conductor suggests a solution.
Truls Norby
doi:10.1038/35073718
Molecular motors: Doing a rotary two-step p878
By spinning around, the ATP synthase converts energy from electrochemical to chemical form for storage. A cunning assay reveals intricate details of the rotation.
Mark J. Schnitzer
doi:10.1038/35073721
Fundamental physics: Newton rules (for now) p881
Three hundred years after Newton explained the falling of an apple and the motion of the planets, physicists are beginning to test his universal law of gravity down to micrometre distances — with interesting results.
Frank Wilczek
doi:10.1038/35073725
Cell biology: Proteolytic relay comes to an end p882
The cellular protein-degrading machinery detects target proteins by the signals they display. One such signal works for artificial test proteins, but only now has a natural equivalent been found.
Martin Scheffner and Noel J. Whitaker
doi:10.1038/35073728
100 and 50 years ago p883
doi:10.1038/35073731
Materials science: Polymers all in a row p885
Optical and electronic devices made from conducting polymers would be cheaper than silicon technology. Using hybrid materials, such as polymer and silica composites, could lead to high-performance devices.
Galen D. Stucky
doi:10.1038/35073733
Vision: Why do colours fade at the edges? p886
Colour vision is much poorer in peripheral parts of the retina than in the centre. It seems that the usual explanation for that finding is flawed.
Andrew Derrington
doi:10.1038/35073736
Daedalus: Adhesive vapours p887
David Jones
doi:10.1038/35073741
Obituary: Minoru Oda (1923–2001) p888
John Maddox
doi:10.1038/35073743
Brief Communications
Subsidence risk from thawing permafrost p889
The threat to man-made structures across regions in the far north can be monitored.
Frederick E. Nelson, Oleg A. Anisimov and Nikolay I. Shiklomanov
doi:10.1038/35073746
First paragraph | Full Text | PDF (485K)
Neuroperception: Early visual experience and face processing p890
Richard Le Grand, Catherine J. Mondloch, Daphne Maurer and Henry P. Brent
doi:10.1038/35073749
First paragraph | Full Text | PDF (256K)
Articles
Increased sedimentation rates and grain sizes 2–4 Myr ago due to the influence of climate change on erosion rates p891
Zhang Peizhen, Peter Molnar and William R. Downs
doi:10.1038/35073504
Abstract | Full Text | PDF (511K) | Supplementary information
Resolution of distinct rotational substeps by submillisecond kinetic analysis of F1-ATPase p898
Ryohei Yasuda, Hiroyuki Noji, Masasuke Yoshida, Kazuhiko Kinosita, Jr and Hiroyasu Itoh
doi:10.1038/35073513
Abstract | Full Text | PDF (706K) | Supplementary information
See also: News and Views by Schnitzer
Letters to Nature
Efficient mixing at low Reynolds numbers using polymer additives p905
Alexander Groisman and Victor Steinberg
doi:10.1038/35073524
First paragraph | Full Text | PDF (367K)
Magnetic-field-induced superconductivity in a two-dimensional organic conductor p908
S. Uji, H. Shinagawa, T. Terashima, T. Yakabe, Y. Terai, M. Tokumoto, A. Kobayashi, H. Tanaka and H. Kobayashi
doi:10.1038/35073531
First paragraph | Full Text | PDF (439K)
Solid acids as fuel cell electrolytes p910
Sossina M. Haile, Dane A. Boysen, Calum R. I. Chisholm and Ryan B. Merle
doi:10.1038/35073536
First paragraph | Full Text | PDF (158K) | Supplementary information
See also: News and Views by Norby
Self-assembly of mesoscopically ordered chromatic polydiacetylene/silica nanocomposites p913
Yunfeng Lu, Yi Yang, Alan Sellinger, Mengcheng Lu, Jinman Huang, Hongyou Fan, Raid Haddad, Gabriel Lopez, Alan R. Burns, Darryl Y. Sasaki, John Shelnutt and C. Jeffrey Brinker
doi:10.1038/35073544
First paragraph | Full Text | PDF (380K) | Supplementary information
See also: News and Views by Stucky
Early Oligocene initiation of North Atlantic Deep Water formation p917
Richard Davies, Joseph Cartwright, Jennifer Pike and Charles Line
doi:10.1038/35073551
First paragraph | Full Text | PDF (733K)
Melt retention and segregation beneath mid-ocean ridges p920
Ulrich H. Faul
doi:10.1038/35073556
First paragraph | Full Text | PDF (184K)
Towards a general theory of biodiversity p923
Elizaveta Pachepsky, John W. Crawford, James L. Bown and Geoff Squire
doi:10.1038/35073563
First paragraph | Full Text | PDF (151K)
Sustainability of three apple production systems p926
John P. Reganold, Jerry D. Glover, Preston K. Andrews and Herbert R. Hinman
doi:10.1038/35073574
First paragraph | Full Text | PDF (147K) | Supplementary information
The concepts of 'sameness' and 'difference' in an insect p930
Martin Giurfa, Shaowu Zhang, Arnim Jenett, Randolf Menzel and Mandyam V. Srinivasan
doi:10.1038/35073582
First paragraph | Full Text | PDF (169K)
Chromatic sensitivity of ganglion cells in the peripheral primate retina p933
Paul R. Martin, Barry B. Lee, Andrew J. R. White, Samuel G. Solomon and Lukas Rüttiger
doi:10.1038/35073587
First paragraph | Full Text | PDF (247K)
See also: News and Views by Derrington
A CaMK IV responsive RNA element mediates depolarization-induced alternative splicing of ion channels p936
Jiuyong Xie and Douglas L. Black
doi:10.1038/35073593
First paragraph | Full Text | PDF (179K) | Supplementary information
Neuropeptide Y functions as a neuroproliferative factor p940
D. E. Hansel, B. A. Eipper and G. V. Ronnett
doi:10.1038/35073601
First paragraph | Full Text | PDF (282K)
Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10 p944
Shian-Huey Chiang, Christian A. Baumann, Makoto Kanzaki, Debbie C. Thurmond, Robert T. Watson, Cheryl L. Neudauer, Ian G. Macara, Jeffrey E. Pessin and Alan R. Saltiel
doi:10.1038/35073608
First paragraph | Full Text | PDF (204K) | Supplementary information
The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors p948
Jane Y. Wu, Lili Feng, Hwan-Tae Park, Necat Havlioglu, Leng Wen, Hao Tang, Kevin B. Bacon, Zhi-hong Jiang, Xiao-chun Zhang and Yi Rao
doi:10.1038/35073616
First paragraph | Full Text | PDF (265K)
Phototropin-related NPL1 controls chloroplast relocation induced by blue light p952
Jose A. Jarillo, Halina Gabrys, Juan Capel, Jose M. Alonso, Joseph R. Ecker and Anthony R. Cashmore
doi:10.1038/35073622
First paragraph | Full Text | PDF (286K) | Supplementary information
Degradation of a cohesin subunit by the N-end rule pathway is essential for chromosome stability p955
Hai Rao, Frank Uhlmann, Kim Nasmyth and Alexander Varshavsky
doi:10.1038/35073627
First paragraph | Full Text | PDF (371K)
See also: News and Views by Scheffner & Whitaker
insight
forewordAIDS p961
Ursula Weiss
perspective
Gulliver's travels in HIVland p963
Robin A. Weiss
doi:10.1038/35073632
Abstract | Full Text | PDF (1,080K)
review article
The global impact of HIV/AIDS p968
Peter Piot, Michael Bartos, Peter D. Ghys, Neff Walker and Bernhard Schwartländer
doi:10.1038/35073639
Abstract | Full Text | PDF (1,453K)
The dynamics of CD4+ T-cell depletion in HIV disease p974
Joseph M. McCune
doi:10.1038/35073648
Abstract | Full Text | PDF (469K)
Cellular immune responses to HIV p980
Andrew J. McMichael and Sarah L. Rowland-Jones
doi:10.1038/35073658
Abstract | Full Text | PDF (1,197K)
Pathways to neuronal injury and apoptosis in HIV-associated dementia p988
Marcus Kaul, Gwenn A. Garden and Stuart A. Lipton
doi:10.1038/35073667
Abstract | Full Text | PDF (1,511K)
HIV chemotherapy p995
Douglas D. Richman
doi:10.1038/35073673
Abstract | Full Text | PDF (596K)
Challenges and opportunities for development of an AIDS vaccine p1002
Gary J. Nabel
doi:10.1038/35073500
Abstract | Full Text | PDF (203K)
foreword
Bristol-Myers Squibb and HIV/AIDS: Basic Science, Clinical Development, Partnerships p1008
Peter Ringrose
doi:10.1038/35073803
