The cellular protein-degrading machinery detects target proteins by the signals they display. One such signal works for artificial test proteins, but only now has a natural equivalent been found.
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Scheffner, M., Whitaker, N. Proteolytic relay comes to an end. Nature 410, 883–885 (2001). https://doi.org/10.1038/35073728
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DOI: https://doi.org/10.1038/35073728
