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Nature 410, 766-767 (12 April 2001) | doi:10.1038/35071218
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Postdoctoral Researchers / Graduate Research Assistant - Center for Physical Activity and Weight Management
- University of Kansas
- Lawrence and Kansas City, KS
Senior Scientist, Cellular & Molecular Pharmacology
- Cortex Search Inc.
- Vancouver, British Columbia
Cell cycle: Checking two steps
Michael B. Kastan
Abstract
When their DNA is damaged, cells temporarily stop multiplying to prevent the build-up of mutations. Two types of delay triggered by ionizing radiation appear to have common molecular starting points.
We thought sequencing the human genome once was daunting enough, but mammalian cells have to copy and segregate their three billion base pairs of DNA with fidelity every time they divide. If the DNA is damaged, the accuracy of this process can decrease, leading to mutations in the DNA of daughter cells.
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