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Nature 410, 527-530 (29 March 2001) | doi:10.1038/35069167
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Neurobiology: Cannabinoids act backwards
MacDonald J. Christie1 & Christopher W. Vaughan1
Abstract
Cannabis is useful for treating many ailments, but has unwanted side effects. Drugs that control signalling by cannabinoids found naturally in the body might be more useful.
Preparations from the plant Cannabis sativa have been used since antiquity, not only for their intoxicating effects, but also to treat a number of ailments1, 2. The main active component of these preparations, 
9-tetrahydrocannabinol, produces most of its effects on the central nervous system by interacting with specific cannabinoid receptors on nerve cells.
- MacDonald J. Christie and Christopher W. Vaughan are in the Department of Pharmacology and The Medical Foundation, The University of Sydney, New South Wales 2006, Australia.
Correspondence to: MacDonald J. Christie1 e-mail: Email: macc@pharmacol.usyd.edu.au
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