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Nature 410, 321-322 (15 March 2001) | doi:10.1038/35066677
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Pharmacology Group Leader
- S*BIO Pte Ltd
- Singapore
Faculty Positions in Immunology
- Harvard Medical School (HMS), Dana-Farber Cancer Institute (DFCI)
- Boston, MA
Structural biology: Protein crystal mimics reality
Robert M. Macnab
Abstract
Flagellin, a protein in the bacterial flagellar motor, has resisted attempts at three-dimensional crystallization — until now. The crystal structure offers hints as to how filaments are able to switch helical states.
Bacteria such as Salmonella and Escherichia coli propel themselves through aqueous environments using flagella. The flagellum has two parts: the filament and the motor.
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