Changes in gene silencing throughout life might be a general phenomenon underlying ageing and longevity: this mechanism is at work in yeast and, as new work suggests, nematode worms.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Tissenbaum, H. A. & Guarente, L. Nature 410, 227–230 (2001).
Guarente, L. & Kenyon, C. Nature 408, 255–262 (2000).
Lin, Y.-J, Seroude, L. & Benzer, S. Science 282, 943–946 (1998).
Brown-Borg, H. M., Borg, K. E., Meliska, C. J. & Bartke, A. Nature 384, 33 (1996).
Coschigano, K., Clemmons, D., Bellush, L. & Kopchick, J. Endocrinology 141, 2608–2613 (2000).
Martínez, D. E. Exp. Gerontol. 33, 217–225 (1998).
Williams, G. C. Evolution 11, 398–411 (1957).
Martin, G. M., Austad, S. N. & Johnson, T. E. Nature Genet. 13, 25–34 (1996).
Sinclair, D. & Guarente, L. Cell 91, 1033–1042 (1997).
Kaeberlein, M., McVey, M. & Guarente, L. Genes Dev. 13, 2570–2580 (1999).
Jamet-Vierny, C., Begel, O. & Belcour, L. Cell 21, 189–194 (1980).
Lin, S., Defossez, P. & Guarente, L. Science 289, 2126–2128 (2000).
Apfeld, J. & Kenyon, C. Nature 402, 804–809 (1999).
Lakowski, B. & Hekimi, S. Proc. Natl Acad. Sci. USA 95, 13091–13096 (1998).
Gems, D. J. Anat. 197, 521–528 (2000).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Gems, D. Yeast longevity gene goes public. Nature 410, 154–155 (2001). https://doi.org/10.1038/35065765
Issue Date:
DOI: https://doi.org/10.1038/35065765